Molecular imaging of brain tumor with PET proliferation tracer
| Project/Area Number |
25461828
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kagawa University |
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Principal Investigator |
Yamamoto Yuka 香川大学, 医学部附属病院, 講師 (30335872)
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| Co-Investigator(Kenkyū-buntansha) |
KUDOMI Nobuyuki 香川大学, 医学部, 准教授 (20552045)
KAWAI Nobuyuki 香川大学, 医学部, 准教授 (40294756)
NISHIYAMA Yoshihiro 香川大学, 医学部, 教授 (50263900)
TOYOHARA Jun 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), その他部局等 (50425659)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 核酸誘導体 / PET / 分子イメージング / 脳腫瘍 / 11C-4DST |
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| Outline of Final Research Achievements |
A novel radiopharmaceutical, 11C-4DST, has been developed as an in vivo cell proliferation marker based on the DNA incorporation method. The purpose of this study was to evaluate 11C-4DST uptake in patients with glioma and to correlate the results with proliferative activity and tumor grade, in comparison with 11C-Methionine and 18F-FLT.
11C-4DST is feasible for imaging of brain gliomas, as well as 11C-Methionine and 18F-FLT. Especially, it showed the highest correlation coefficient between 11C-4DST and Ki-67 index in newly diagnosed gliomas.
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Report
(4 results)
Research Products
(11 results)
