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An establishment of the diagnostic method of orbit malignant melanoma by the molecular imaging procedure using I-123 IMP

Research Project

Project/Area Number 25461832
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionTokyo Women's Medical University

Principal Investigator

Abe Koichiro  東京女子医科大学, 医学部, 教授 (00380387)

Co-Investigator(Kenkyū-buntansha) 丸岡 保博  九州大学, 大学病院, 助教 (00637928)
藤田 陽子  九州大学, 大学病院, 助教 (30644760)
吉武 忠正  九州大学, 医学研究院, 講師 (40452750)
北村 宜之  九州大学, 大学病院, 助教 (70644722)
馬場 眞吾  九州大学, 大学病院, 講師 (80380450)
本田 浩  九州大学, 医学研究院, 教授 (90145433)
磯田 拓郎  札幌医科大学, 医学部, 助教 (90452747)
福島 賢慈  東京女子医科大学, 医学部, 講師 (50408613)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords眼窩悪性黒色腫 / IMP-SPECT / 診断 / 放射線治療 / I-123 IMP SPECT / 診断能 / MRI / FDG-PET / I-123 IMP-SPECT
Outline of Final Research Achievements

The purpose of this study was to address the clinical value of N-isopropyl-p-[I-123]-iodoamphetamine SPECT (IMP-SPECT) in the diagnosis and in the follow-up after radiotherapy of ocular malignant melanoma (MM). Forty-three patients with clinically suspected ocular MM were examined and 16 patients (39.0%) were finally histopathologically diagnosed as MM. SPECT were taken at 15 min, 4 hr, 24 hr and 48 hr after IMP administration. All patients underwent IMP-SPECT and MRI and 12 of them underwent FDG-PET. We also picked up 15 MM patients who had IMP-SPECT several times before and after radiotherapy. At 48 hours after IMP administration, IMP-SPECT showed highest sensitivity (87.5 %) and accuracy (88.4%), that were higher than MRI and FDG-PET. On the other hand, IMP accumulation gradually decreased and finally disappeared 2-3 years after radiotherapy. This study shows that IMP-SPECT is useful tool for the diagnosis of ocular MM and for the follow-up of patients with MM after radiotherapy.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (2 results)

All 2013

All Presentation (2 results)

  • [Presentation] Clinical value of IMP-SPECT in the follow-up of choroidal melanoma after radiotherapy2013

    • Author(s)
      Koichiro Abe, Shingo Baba, Yasuhiro Maruoka, Yoshiyuki Kitamura, Masayuki Sasaki, Hiroshi Honda, Shuji Sakai
    • Organizer
      Society of Nuclear Medicine
    • Place of Presentation
      Vancouver
    • Related Report
      2013 Research-status Report
  • [Presentation] 眼窩メラノーマ放射線治療後経過観察におけるIMP-SPECTの意義2013

    • Author(s)
      阿部光一郎、馬場眞吾、丸岡保博、北村宜之、近藤千里、百瀬満、福島賢慈、本田浩、坂井修二
    • Organizer
      日本核医学会総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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