Estimation of tumor grade, therapeutic effect and patients' prognosis using CEST in pelvic tumors

• Project/Area Number: 25461833
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: Nishie Akihiro 九州大学, 医学(系)研究科(研究院), 講師 (20457427)
• Co-Investigator(Kenkyū-buntansha): Asayama Yoshiki 九州大学, 医学研究院, 教授 (40380414) ; Ushijima Yasuhiro 九州大学, 医学研究院, 助教 (40432934) ; Takayama Yukihisa 九州大学, 医学研究院, 助教 (60546563) ; Fujita Nobuhiro 九州大学, 大学病院, 助教 (30610612) ; Yoshiura Takashi 鹿児島大学, 医学部, 教授 (40322747) ; Togao Osamu 九州大学, 大学病院, 助教 (10452749) ; Honda Hiroshi 九州大学, 医学研究院, 教授 (90145433)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: CEST / APT imaging / 骨盤内腫瘍 / 悪性度 / 治療効果 / 予後 / 子宮癌 / MRI / 組織型 / 前立腺癌 / グリソンスコア / 直腸癌 / 分化度 / タンパク / ムチン

Outline of Final Research Achievements

Tumor grade and chemotherapeutic effect in rectal cancer, Gleason score in prostate cancer and histological subtype in uterine cancer can be predicted by amide proton transfer (APT) imaging, which is a representative of chemical exchange saturation transfer imaging. APT signal intensity (APTSI) obtained by this imaging reportedly reflects the amount of proteins and peptides. According to our results, APTSI is considered to suggest not only the difference in cell division but also the amount of intra- and extracellular mucin and soluble proteins in the glands for adenocarcinoma. APTSI could be a new biomarker for evaluating tumor aggressiveness.

Research Products

• [Presentation] 腹部領域での定量化イメージングの新たな試み ーChemical exchange saturation transfer imagingを中心にー (2014)
  • Author(s): 西江昭弘
  • Organizer: 第28回腹部放射線学会
  • Place of Presentation: 秋田市
  • Year and Date: 2014-06-27 – 2014-06-28
  • Invited
• [Presentation] 直腸癌におけるchemical exchange saturation transfer imagingを用いた腫瘍悪性度の評価 (2013)
  • Author(s): 西江昭弘、浅山良樹、牛島泰宏、藤田展宏、島本 大、鶴丸大介、栂尾 理、吉浦 敬、本田 浩、高山幸久、久保雄一郎、小原 真、Jochen Keupp
  • Organizer: 第41回日本磁気共鳴医学会大会
  • Place of Presentation: 徳島
• [Presentation] MR prediction of tumor grade in rectal cancer using chemical exchange saturation transfer imaging (2013)
  • Author(s): Akihiro Nishie, Yoshiki Asayama, Yasuhiro Ushijima, Yukihisa Takayama, Nobuhiro Fujita, Hiroshi Honda, Dai Shimamoto, Osamu Togao, Takashi Yoshiura, Makoto Obara, Jochen Keupp
  • Organizer: RSNA 99th SCIENTIFIC ASSEMBLY & ANNUAL MEETING
  • Place of Presentation: Chicago, USA