| Project/Area Number |
25461842
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Osaka City University |
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Principal Investigator |
Miki Yukio 大阪市立大学, 大学院医学研究科, 教授 (80303824)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAI Kouji 京都大学, 大学院医学研究科, 講師 (20379027)
SHIMADA Hiroyuki 大阪市立大学, 大学院医学研究科, 特任教授 (90254391)
SHIMONO Taro 大阪市立大学, 大学院医学研究科, 准教授 (70340817)
TAKEDA Akitoshi 大阪市立大学, 大学院医学研究科, 講師 (90445015)
SAKAMOTO Shinichi 大阪市立大学, 大学院医学研究科, 講師 (40464648)
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| Research Collaborator |
SAI Asari 大阪市立総合医療センター
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脳 / 磁気共鳴画像 / MRI / 脱髄疾患 / 温度 / 月経周期 / 脳温度 / 拡散強調画像 / 磁気共鳴画像(MRI) / 女性 / 核磁気共鳴画像(MRI) / 多発性硬化症 |
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| Outline of Final Research Achievements |
Brain temperature was measured using diffusion-weighted imaging-based MR thermometry of the lateral ventricles.
Our investigation revealed that brain temperature was significantly lower in MS patients (n=13) than in healthy controls (n=13). This probably represents decreased brain metabolism in MS patients. We also measured brain temperature of 20 healthy female volunteers (21.3-38.8 years of age) during both follicular and luteal phases, and found that brain temperature was significantly higher in luteal phase than in follicular phase.
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