| Project/Area Number |
25461844
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Makoto 岩手医科大学, 超高磁場MRI診断・病態研究部門, 教授 (80205864)
NAKAMURA Yutaka 岩手医科大学, 呼吸器アレルギー膠原病内科, 准教授 (60328614)
KOBAYASHI Hitoshi 岩手医科大学, 呼吸器アレルギー膠原病内科, 准教授 (60215358)
MIZUNO Manori 岩手医科大学, 神経内科, 助教 (70382603)
FUKUMOTO Kentarou 岩手医科大学, 精神神経科, 助教 (00514407)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 中枢神経ループス / 早期診断 / 7TeslaMRI / 全身性エリテマトーデス / 7Tesla MRI / 髄質動静脈 / 脳微細血管炎 / 脳微小血管病変 / 診断 / 中心溝 |
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| Outline of Final Research Achievements |
On the high-resolution T1WIs obtained at 7 T, minute punctate/linear hyperintense lesions in subcortical and/or cortical areas were found in four (80%)neuropsychiatric systemic lupus erythematosus(NPSLE) patients and one (7%) non-NPSLE patient. Further, the minute punctate enhanced lesions in these areas were found on contrast-enhanced T1WIs in only three (60%) NPSLE patients. These findings suggesting microvascular thrombi or inflammation were significantly more frequent in NPSLE than in non-NPSLE patients (P=0.001). In contrast, other imaging findings, laboratory findings, and clinical characteristics were not different between the two groups. High-resolution T1WIs obtained at 7 T can detect minute lesions, indicating intracerebral microvascular lesions in patients with NPSLE.
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