Detection of cerebral microvascular lesions using 7 T MRI in patients with neuropsychiatric systemic lupus erythematosus.

• Project/Area Number: 25461844
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Iwate Medical University
• Principal Investigator: SASAKI Nobuhito 岩手医科大学, 医学部, 講師 (50382601)
• Co-Investigator(Kenkyū-buntansha): SASAKI Makoto 岩手医科大学, 超高磁場MRI診断・病態研究部門, 教授 (80205864) ; NAKAMURA Yutaka 岩手医科大学, 呼吸器アレルギー膠原病内科, 准教授 (60328614) ; KOBAYASHI Hitoshi 岩手医科大学, 呼吸器アレルギー膠原病内科, 准教授 (60215358) ; MIZUNO Manori 岩手医科大学, 神経内科, 助教 (70382603) ; FUKUMOTO Kentarou 岩手医科大学, 精神神経科, 助教 (00514407)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 中枢神経ループス / 早期診断 / 7TeslaMRI / 全身性エリテマトーデス / 7Tesla MRI / 髄質動静脈 / 脳微細血管炎 / 脳微小血管病変 / 診断 / 中心溝

Outline of Final Research Achievements

On the high-resolution T1WIs obtained at 7 T, minute punctate/linear hyperintense lesions in subcortical and/or cortical areas were found in four (80%)neuropsychiatric systemic lupus erythematosus(NPSLE) patients and one (7%) non-NPSLE patient. Further, the minute punctate enhanced lesions in these areas were found on contrast-enhanced T1WIs in only three (60%) NPSLE patients. These findings suggesting microvascular thrombi or inflammation were significantly more frequent in NPSLE than in non-NPSLE patients (P=0.001). In contrast, other imaging findings, laboratory findings, and clinical characteristics were not different between the two groups. High-resolution T1WIs obtained at 7 T can detect minute lesions, indicating intracerebral microvascular lesions in patients with NPSLE.

Research Products

• [Journal Article] A phosphatidylinositol 3-kinase inhibitor strongly suppressed pulmonary vascular remodeling of allergic vasculitis in a murine model (2016)
  • Author(s): Oikawa Y, Sasaki N, Niisato M, Nakamura Y, Yamauchi K
  • Journal Title: Exp Lung Res Volume: 17 Issue: 3 Pages: 1-10
  • DOI: 10.3109/01902148.2016.1157226
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Impact of the Static and Radiofrequency Magnetic Fields Produced by a 7T MR Imager on Metallic Dental Materials (2016)
  • Author(s): Kenta ORISO, Takuya KOBAYASHI, Makoto SASAKI, Ikuko UWANO, Hidemichi KIHARA, Hisatomo KONDO
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 15 Issue: 1 Pages: 26-33
  • DOI: 10.2463/mrms.2014-0122
  • NAID: 130005118988
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Periostin in the bronchial lavage fluid of asthma patients (2015)
  • Author(s): akamura, Y., Nagashima, H., Ohta, S., Ono, J., Yamauchi, K. & Izuhara, K.
  • Journal Title: Allergology International Volume: 64 Issue: 2 Pages: 209-210
  • DOI: 10.1016/j.alit.2015.01.001
  • NAID: 130005290284
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Differentiation among parkinsonisms using quantitative diffusion kurtosis imaging (2015)
  • Author(s): Ito K, Sasaki M, Ohtsuka C, Yokosawa S, Harada T, Uwano I, Yamashita F, Higuchi S, Terayama Y
  • Journal Title: Neuroreport Volume: 26(5) Issue: 5 Pages: 267-272
  • DOI: 10.1097/wnr.0000000000000341
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Carotid Plaque Characterization Using 3D T1-Weighted MR Imaging with Histopathologic Validation: A Comparison with 2D Technique (2015)
  • Author(s): S. Narumi, M. Sasaki, T. Natori, M.Y. Oura, K. Ogasawara, M. Kobayashi, Y. Sato, Y. Ogasawara, J. Hitomi, and Y. Terayama
  • Journal Title: American journal of neuroradiology Volume: 36 Issue: 4 Pages: 751-756
  • DOI: 10.3174/ajnr.a4197
  • Peer Reviewed / Open Access
• [Journal Article] Detection of cerebral microvascular lesions using 7 T MRI in patients with neuropsychiatric systemic lupus erythematosus. (2015)
  • Author(s): Murata O, Sasaki N, Sasaki M, Kowada K, Ninomiya Y, Oikawa Y, Kobayashi H, Nakamura Y, Yamauchi K.
  • Journal Title: Neuroreport Volume: 26(7) Pages: 26-32
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Rapamycin attenuates pulmonary allergic vasculitis in murine model by reducing TGF-β production in the lung. (2014)
  • Author(s): Koizumi R, Sasaki N, Nakamura Y, Suzuki N, Sawai T, Yamauchi K.
  • Journal Title: Allergology International Volume: 63(3) Pages: 457-466
  • NAID: 130004687704
  • Peer Reviewed / Open Access
• [Journal Article] Effects of imatinib mesylate on pulmonary allergic vasculitis in murine model (2013)
  • Author(s): Suzuki N, Sasaki N, et.al.
  • Journal Title: International Journal of Rheumatic Diseases Volume: 16 Issue: 4 Pages: 455-462
  • DOI: 10.1111/1756-185x.12075
  • Peer Reviewed
• [Journal Article] Association of IL-13 gene polymorphisms with airway hyperresponsiveness in a Japanese adult asthmatic population. (2013)
  • Author(s): Utsumi Y, Sasaki N, Nagashima H, Suzuki N, Nakamura Y, Yamashita M, Kobayashi H, Yamauchi K
  • Journal Title: Respir Investig Volume: 51 Issue: 3 Pages: 147-152
  • DOI: 10.1016/j.resinv.2013.02.003
  • Peer Reviewed
• [Journal Article] Scedosporium aurantiacum brain abscess after near-drowning in a survivor of a tsunami in Japan. (2013)
  • Author(s): Nakamura Y, Suzuki N, Nakajima Y, Utsumi Y, Murata O, Nagashima H, Saito H, Sasaki N, et.al.
  • Journal Title: Respiratory Investigation Volume: 51 Issue: 4 Pages: 208-211
  • DOI: 10.1016/j.resinv.2013.07.001
  • Peer Reviewed
• [Journal Article] 長期寛解が得られたステロイド抵抗性筋炎の1例 (2013)
  • Author(s): 佐々木信人、他
  • Journal Title: アレルギーの臨床 Volume: 33 Pages: 57-61
• [Journal Article] シェーグレン症候群と肺病変 (2013)
  • Author(s): 佐々木信人、他
  • Journal Title: 呼吸 Volume: 33 Pages: 612-618
• [Presentation] A phosphatidylinositol 3-kinase inhibitor strongly suppressed pulmonary vascular remodeling of allergic vasculitis in a murine model. (2015)
  • Author(s): Oikawa Y, Sasaki N, Niisato M1, Nakamura Y1, Yamauchi K1.
  • Organizer: ERS International Congress 2015
  • Place of Presentation: Amsterdam
  • Year and Date: 2015-09-26
  • Int'l Joint Research
• [Presentation] Effects of Rapamycin on Pulmonary Vascular Remodeling of Allergic Vasculitis in Murine Model. (2014)
  • Author(s): Sasaki N, Nakamura Y, Suzuki N, Sawai T, Yamauchi K.
  • Organizer: American Thoracic Society international conference
  • Place of Presentation: サンディエゴ, USA
  • Year and Date: 2014-05-16 – 2014-05-21
• [Presentation] Detection of novel cerebral microvessel lesions in patients with neuropsychiatric systemic (2013)
  • Author(s): Sasaki N, et.al.
  • Organizer: Annual European Congress or Rheumatology
  • Place of Presentation: マドリード、スペイン
• [Presentation] Detection of cerebral microvascular lesions in patients with acute phase neuropsychiatric systemic lupus erythematosus by 7Tesla MRI (2013)
  • Author(s): Sasaki N, et.al.
  • Organizer: American college Rheumatology Annual Meeting
  • Place of Presentation: サンディエゴ、米国