Preliminary studies on therapy of bone metastases by alpha-emitter radium-223

• Project/Area Number: 25461854
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kindai University
• Principal Investigator: HOSONO Makoto 近畿大学, 医学部附属病院, 教授 (00281303)
• Co-Investigator(Renkei-kenkyūsha): HOHARA Shinya 近畿大学, 原子力研究所, 准教授 (90434860)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ラジウム-223 / radium-223 / α線 / 放射線計測 / 線量評価 / アルファ線 / Ra-223 / 前立腺癌 / アルファ線放出核種 / 去勢抵抗性前立腺癌 / 骨転移 / GM計数管 / Na(Tl)シンチレーション計数管 / ZnS(Ag)検出器 / ゲルマニウム半導体検出器 / 光子計測 / アルファ放出核種 / 高純度ゲルマニウム半導体検出器 / NaI(Tl)シンチレーション計数管

Outline of Final Research Achievements

The alpha-emitter radium-223 (Ra-223), which has an affinity to the bone, has been introduced into clinical practices as a therapeutic radiopharmaceutical that prolongs overall survival in castration-resistant prostate cancer with bone metastases. In this study, we conducted studies on measurements of photons by various counting devices in order to clarify the physiochemical properties of Ra-223, on decontamination methods assuming contamination of materials, and also appropriate parameters for imaging by gamma camera. We demonstrated the characteristics of GM counters，Na(Tl) scintillation counters, and a ZnS(Ag) counter, the importance of early decontamination of materials, and feasibility of gamma rays and characteristic X rays for imaging.

Research Products

• [Journal Article] Influence of acquisition orbit on phase analysis of gated single photon emission computed tomography myocardial perfusion imaging for assessment of left ventricular mechanical dyssynchrony (2017)
  • Author(s): Misaka T, Hosono M, Kudo T, Ito T, Syomura T, Uemura M, Okajima K
  • Journal Title: Ann Nucl Med Volume: 31 Issue: 3 Pages: 235-244
  • DOI: 10.1007/s12149-017-1151-x
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clinical outcomes of IMRT planned with or without PET/CT simulation for patients with pharyngeal cancers (2017)
  • Author(s): Matsuura T, Nishimura Y, Nakamatsu K, Kanamori S, Ishikawa K, Tachibana I, Hosono M, Shibata T.
  • Journal Title: Int J Clin Oncol Volume: 22 Issue: 1 Pages: 52-58
  • DOI: 10.1007/s10147-016-1034-5
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A new shielding calculation method for X-ray computed tomography regarding scattered radiation (2016)
  • Author(s): Watanabe H, Noto K, Shohji T, Ogawa Y, Fujibuchi T, Yamaguchi I, Hiraki H, Kida T, Sasamura K, Katsunuma Y, Nakano T, Horitsugi G, Hosono M
  • Journal Title: Radiological Physics and Technology Volume: 1 Issue: 2 Pages: 1-14
  • DOI: 10.1007/s12194-016-0387-9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Estimation of activity of administered 18F-fluorodeoxyglucose by measurement of the dose equivalent rate on the right temporal region of the head (2016)
  • Author(s): Sakaguchi k, Hosono M, Imamura T, Takahara N, Hayashi M, Yakushiji Y, Ishii K, Uto T, Murakami T
  • Journal Title: EJNMMI Phys Volume: 3 Issue: 1 Pages: 1-9
  • DOI: 10.1186/s40658-016-0164-1
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Report of a nationwide survey on actual administered radioactivities of radiopharmaceuticals for diagnostic reference levels in Japan. (2016)
  • Author(s): Watanabe H, Ishii K, Hosono M, Imabayashi E, Abe K, Inubushi M, Ohno K, Magata Y, Ono K, Kikuchi K, Wagatsuma K, Takase T, Saito K, Takahashi Y.
  • Journal Title: Ann Nucl Med. Volume: 30 Issue: 6 Pages: 435-444
  • DOI: 10.1007/s12149-016-1079-6
  • Peer Reviewed / Open Access
• [Journal Article] RI内用療法の将来展望と提言 (2016)
  • Author(s): 東 達也、池渕秀治、内山眞幸、織内 昇、絹谷清剛、細野 眞
  • Journal Title: 核医学 Volume: 53 Pages: 27-43
  • NAID: 130005150686
  • Peer Reviewed
• [Journal Article] Wakabayashi G, Nohtomi A, Yahiro E, Fujibuchi, Fukunaga J, Umezu Y, Nakamura Y, Nakamura K, Hosono M, Itoh T. Applicability of self-activation of an NaI scintillator for measurement of photo-neutrons around a high-energy X-ray radiotherapy machine (2015)
  • Author(s): Wakabayashi G, Nohtomi A, Yahiro E, Fujibuchi, Fukunaga J, Umezu Y, Nakamura Y, Nakamura K, Hosono M, Itoh T
  • Journal Title: Radiol Phys Technol Volume: 8 Pages: 125-134
  • Peer Reviewed
• [Journal Article] Heterogeneity of intratumoral 111In-ibritumomab tiuxetan and 18F-FDG distribution in association with therapeutic response in radioimmunotherapy for B-cell non-Hodgkin’s lymphoma (2015)
  • Author(s): Hanaoka K, Hosono M, Tatsumi Y, Ishii K, Im SW, Tsuchiya N, Sakaguchi K, Matsumura I
  • Journal Title: EJNMMI Research Volume: 5 Issue: 1 Pages: 10-10
  • DOI: 10.1186/s13550-015-0093-3
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Performance of 11C-Pittsburgh Compound B PET binding potential images in the detection of amyloid deposits on equivocal static images (2015)
  • Author(s): Hosokawa C, Ishii K, Kimura Y, Hyodo T, Hosono M, Sakaguchi K, Usami K, Shimamoto K, Yamazoe Y, Murakami T
  • Journal Title: J Nucl Med Volume: 56 Issue: 12 Pages: 1910-1915
  • DOI: 10.2967/jnumed.115.156414
  • Peer Reviewed
• [Journal Article] がんの骨転移及び原発性骨腫瘍等の治療に用いられる放射性ラジウム-223の有効性及び投与された患者の管理区域からの退出などの放射線防護対策について、塩化ラジウム（Ra-223）注射液を用いた内用療法の治験適正使用マニュアル（第2版）（案） (2015)
  • Author(s): 細野 眞、宇佐美公男、坂口健太、花岡宏平、上田いづみ、池渕秀治、中村吉秀、中村伸貴、山田崇裕、柳田幸子、北岡麻美
  • Journal Title: 平成26年度厚生労働科学研究費補助金 地域医療基盤開発推進研究事業「医療における放射線防護と関連法令整備に関する研究」（H26-医療-一般-019）（研究代表者：細野 眞）分担研究報告書 Volume: 1 Pages: 1-38
• [Journal Article] ルテチウム-177-DOTA-TATE注射液の適正使用に関する検討、ルテチウム-177標識ソマトスタチンアナログ（Lu-177-DOTA-TATE）注射液を用いる内用療法の適正使用マニュアル（案） (2015)
  • Author(s): 細野 眞、池渕秀治、中村吉秀、中村伸貴、柳田幸子、北岡麻美、小島清孝、菅野宏泰
  • Journal Title: 平成26年度厚生労働科学研究費補助金 地域医療基盤開発推進研究事業「医療における放射線防護と関連法令整備に関する研究」（H26-医療-一般-019）（研究代表者：細野 眞）分担研究報告書 Volume: 1 Pages: 39-75
• [Journal Article] Applicability of self-activation of an NaI scintillator for measurement of photo-neutrons around a high-energy X-ray radiotherapy machine (2015)
  • Author(s): Wakabayashi G, Nohtomi A, Yahiro E, Fujibuchi, Fukunaga J, Umezu Y, Nakamura Y, Nakamura K, Hosono M, Itoh T
  • Journal Title: Radiol Phys Technol Volume: 8 Issue: 1 Pages: 125-134
  • DOI: 10.1007/s12194-014-0300-3
  • Peer Reviewed
• [Journal Article] Regional glucose metabolic reduction in dementia with Lewy bodies is independent of amyloid deposition (2015)
  • Author(s): Ishii K, Hosokawa C, Hyodo T, Sakaguchi K, Usami K, Shimamoto K, Hosono M, Yamazoe Y, Murakami T
  • Journal Title: Ann Nucl Med Volume: 29 Issue: 1 Pages: 78-83
  • DOI: 10.1007/s12149-014-0911-0
  • Peer Reviewed
• [Journal Article] Investigation of 11C-PiB equivocal PET findings (2015)
  • Author(s): Hosokawa C, Ishii K, Hyodo T, Sakaguchi K, Usami K, Shimamoto K, Yamazoe Y, Hosono M, Hanada K, Ueda M, Saigo K, Murakami T
  • Journal Title: Ann Nucl Med Volume: 29 Issue: 2 Pages: 164-169
  • DOI: 10.1007/s12149-014-0924-8
  • Peer Reviewed
• [Journal Article] Clinical practice guideline for dedicated breast PET (2014)
  • Author(s): Hosono M, Saga T, Ito K, Kumita S, Sasaki M, Senda M, Hatazawa J, Watanabe H, Ito H, Kanaya S, Kimura Y, Saji H, Jinnouchi S, Fukukita H, Murakami K, Kinuya S, Yamazaki J, Uchiyama M, Uno K, Kato K, Kawano T, Kubota K, Togawa T, Honda N, Maruno H, Yoshimura M, Kawamoto M, Ozawa Y
  • Journal Title: Ann Nucl Med Volume: 28 Issue: 6 Pages: 597-602
  • DOI: 10.1007/s12149-014-0857-2
  • Peer Reviewed
• [Journal Article] Measurements for a Contamination Control of a ²²³Ra Medicament (2013)
  • Author(s): 芳原新也、細野 眞、稲垣昌代、任 誠雲、森元英夫、花岡宏平、坂口健太、山西弘城、伊藤哲夫
  • Journal Title: RADIOISOTOPES Volume: 62 Issue: 9 Pages: 659-665
  • DOI: 10.3769/radioisotopes.62.659
  • NAID: 10031194103
  • ISSN: 0033-8303, 1884-4111
  • Peer Reviewed
• [Journal Article] α線内用療法の現状と展望 (2013)
  • Author(s): 細野 眞
  • Journal Title: Isotope News Volume: 720 Pages: 2-7
  • NAID: 10031183017
• [Journal Article] A Prospective Clinical Trial of Tumor Hypoxia Imaging with 18F-fluoromisonidazole Positron Emission Tomography and Computed Tomography (F-MISO PET/CT) before and during Radiation Therapy (2013)
  • Author(s): Tachibana I, Nishimura Y, Shibata T, Kanamori S, Nakamatsu K, Koike R, Nishikawa T, Ishikawa K, Tamura M, Hosono M
  • Journal Title: J Radiation Research Volume: 54 Issue: 6 Pages: 1078-84
  • DOI: 10.1093/jrr/rrt033
  • Peer Reviewed
• [Journal Article] Dynamic sequence respiratory gated perfusion pulmonary SPECT without external tracking device (2013)
  • Author(s): Sakaguchi K, Hosono M, Otsuka M, Hanaoka K, Usami K, Uto T, Ishii K
  • Journal Title: Ann Nucl Med Volume: 27 Issue: 1 Pages: 65-73
  • DOI: 10.1007/s12149-012-0658-4
  • NAID: 10031168069
  • Peer Reviewed
• [Presentation] . Clinical evaluation and optimization of a new PET reconstruction algorithm Q.Clear in lung cancer (2017)
  • Author(s): Otani T, Hosono M, Kanagaki M, Fukumoto G, Onishi Y, Matsubara N, Kimura H
  • Organizer: ECR 2017
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2017-02-28
• [Presentation] Theranostics: イメージングと治療の融合 (2016)
  • Author(s): 細野 眞
  • Organizer: 第56回日本核医学会学術総会
  • Place of Presentation: 名古屋国際会議場 名古屋
  • Year and Date: 2016-11-03
  • Invited
• [Presentation] Survey and decontamination of radium-223 dichloride for alpha- particle radionuclide therapy in clinical facilities (2016)
  • Author(s): Hosono M, Hohara S, Inagaki M, Yamanishi H, Wakabayashi G, Matsuda T, Sakaguchi K, Hanaoka K, Ito T
  • Organizer: Annual Congress of European Association of Nuclear Medicine
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2016-10-15
  • Int'l Joint Research
• [Presentation] Estimation of administered fluorodeoxyglucose activity in patients on the basis of dose equivalent rate on head by multiple regression analysis (2016)
  • Author(s): Hosono M, Sakaguchi K, Imamura T, Takahara N, Hayashi M, Hosokawa C, Yamada M, Ishii K
  • Organizer: Annual Congress of European Association of Nuclear Medicine
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2016-10-15
  • Int'l Joint Research
• [Presentation] Survey on radionuclide therapy facilities in Japan with grants by Ministry of Health, Labour, and Welfare (2016)
  • Author(s): Hosono M, Ikebuchi H, Nakamura Y, Nakamura N, Yanagida S, Kitaoka
  • Organizer: Annual Congress of European Association of Nuclear Medicine
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2016-10-15
  • Int'l Joint Research
• [Presentation] JSNM Education, Accreditation, and Multidisciplinary Team Practice (2016)
  • Author(s): Hosono M
  • Organizer: Annual Meeting of Society of Nuclear Medicine
  • Place of Presentation: San Diego, California, USA
  • Year and Date: 2016-06-11
  • Int'l Joint Research / Invited
• [Presentation] Texture analysis for FMISO PET/CT in oncology patients receiving extra-beam radiation therapy (2016)
  • Author(s): Hosono M, Tachibana I, Nishimura Y, Hanaoka K, Sakaguchi K, Ishikawa K, Nakamatsu K, Kanamori S
  • Organizer: Annual Meeting of Society of Nuclear Medicine
  • Place of Presentation: San Diego, California, USA
  • Year and Date: 2016-06-11
  • Int'l Joint Research
• [Presentation] Pretherapeutic FDG heterogeneity in tumors can predict local control in oropharyngeal cancer patients undergoing intensity-modulated radiation therapy (2016)
  • Author(s): Hanaoka K, Hosono M, Tatebe H, Ishikawa K, Monzen H, Ishii K, Nishimura Y
  • Organizer: Annual Meeting of Society of Nuclear Medicine
  • Place of Presentation: San Diego, California, USA
  • Year and Date: 2016-06-11
• [Presentation] Dose evaluation and control for Nuclear Medicine (2016)
  • Author(s): Hosono M
  • Organizer: Japan Radiology Congress 2016
  • Place of Presentation: Pacifico Yokohama(Yokohama)
  • Year and Date: 2016-04-14
  • Int'l Joint Research / Invited
• [Presentation] Texture analysis for tumor hypoxia visualized by FMISO PET/CT during radiation therapy (2015)
  • Author(s): Hosono M, Tachibana I, Nishimura Y, Hanaoka K, Kanamori S, Nakamatsu K, Ishikawa K, Sakaguchi K
  • Organizer: Annual Congress of European Association of Nuclear Medicine
  • Place of Presentation: Hamburg, Germany
  • Year and Date: 2015-10-10
  • Int'l Joint Research
• [Presentation] Occupational radiation exposure of nursing staff in PET facility in association with performance status of patients (2015)
  • Author(s): Hosono M, Takahara N, Yakushiji Y, Sakaguchi K, Yamada Y, Hosokawa C, Ishii K
  • Organizer: Annual Congress of European Association of Nuclear Medicine
  • Place of Presentation: Hamburg, Germany
  • Year and Date: 2015-10-10
  • Int'l Joint Research
• [Presentation] Therapy planning and dose prescription in radioiodine-131 therapy for hyperthyroidism using radioiodine-123 SPECT/CT imaging (2015)
  • Author(s): Hanaoka K, Hosono M, Otsuka M, Asai Y, Okumura M, Ishii K, Murakami T
  • Organizer: Annual Congress of European Association of Nuclear Medicine
  • Place of Presentation: Hamburg, Germany
  • Year and Date: 2015-10-10
  • Int'l Joint Research
• [Presentation] Feasibility of heterogeneity analysis for intratumoral hypoxia on FMISO PET/CT in radiation therapy (2015)
  • Author(s): Hosono M, Tachibana I, Nishimura Y, Hanaoka K, Kanamori S, Nakamatsu K, Ishikawa K
  • Organizer: SNMMI 2015 Annual Meeting
  • Place of Presentation: Baltimore, MD, USA
  • Year and Date: 2015-06-06
  • Int'l Joint Research
• [Presentation] Radiation exposure of nursing staff in PET practices in correlation to performance status of patients (2015)
  • Author(s): Hosono M, Takahara N, Yakushiji Y, Sakaguchi K, Ishii K
  • Organizer: SNMMI 2015 Annual Meeting
  • Place of Presentation: Baltimore, MD, USA
  • Year and Date: 2015-06-06
  • Int'l Joint Research
• [Presentation] Measurement and parameters of α-emitting radium-223 for radionuclide therapy in accordance with radiation protection standards (2014)
  • Author(s): Hosono M, Hohara S, Yamanishi H, Inagaki M, Wakabayashi G, Matsuda T, Sakaguchi K, Hanaoka K, Itoh T
  • Organizer: Annual Congress of European Association of Nuclear Medicine
  • Place of Presentation: Gothenburg, Sweden
  • Year and Date: 2014-10-18 – 2014-10-22
• [Presentation] Predictive value of heterogeneity of intratumoral In-111-Zevalin and FDG distributions for tumor response in Zevalin therapy (2014)
  • Author(s): Hosono M, Hanaoka K, Ishii K, Sakaguchi K, Yamada M, Komeya Y, Tsuchiya N, Im SW, Tatsumi Y, Matsumura I
  • Organizer: Annual Congress of European Association of Nuclear Medicine
  • Place of Presentation: Gothenburg, Sweden
  • Year and Date: 2014-10-18 – 2014-10-22
• [Presentation] Texture analysis of intratumoral hypoxia on FMISO PET/CT in radiation therapy (2014)
  • Author(s): Hosono M, Tachibana I, Nishimura Y, Hanaoka K, Kanamori S, Nakamatsu K, Ishikawa K
  • Organizer: Annual Congress of European Association of Nuclear Medicine
  • Place of Presentation: Gothenburg, Sweden
  • Year and Date: 2014-10-18 – 2014-10-22
• [Presentation] Hosono M, Tachibana I, Nishimura Y, Hanaoka K, Kanamori S, Nakamatsu K, Shibata T, Ishikawa K, Tamura M. Heterogeneity of intratumoral hypoxia on FMISO PET/CT in association with local control in radiation therapy (2014)
  • Author(s): Hosono M, Tachibana I, Nishimura Y, Hanaoka K, Kanamori S, Nakamatsu K, Shibata T, Ishikawa K, Tamura M K, Shibata T, Ishikawa K, Tamura M
  • Organizer: ASTRO 2014
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2014-09-14 – 2014-09-17
• [Presentation] Measurement and radiation control of α-emitting radium-223 in radionuclide therapy for prostate cancer with bone metastases (2014)
  • Author(s): Hosono M, Hohara S, Yamanishi H, Inagaki M, Wakabayashi G, Sakaguchi K, Hanaoka K, Itoh T
  • Organizer: SNMMI 2014 Annual Meeting
  • Place of Presentation: St Louis, MO, USA
  • Year and Date: 2014-06-07 – 2014-06-11
• [Presentation] Heterogeneity of intratumoral In-111-Zevalin and FDG distribution in association with therapeutic response in radioimmunotherapy for B-cell lymphoma (2014)
  • Author(s): Hosono M, Hanaoka K, Ishii K, Sakaguchi K, Im SW, Tsuchiya N, Yoshihiro K, Tatsumi Y, and Matsumura I
  • Organizer: SNMMI 2014 Annual Meeting
  • Place of Presentation: St Louis, MO, USA
  • Year and Date: 2014-06-07 – 2014-06-11
• [Presentation] アルファ放出核種ラジウム-223による骨転移内照射療法の実際と適正な測定管理に関する検討 (2014)
  • Author(s): 細野 眞、芳原新也、稲垣昌代、山西弘城、若林源一郎、任 誠雲、森元英夫、坂口健太、花岡宏平、伊藤哲夫
  • Organizer: 第73回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Measurement and radiation control of α-emitting radium-223 in radionuclide therapy for prostate cancer with bone metastases (2014)
  • Author(s): Hosono M, Hohara S, Yamanishi H, Inagaki M, Wakabayashi G, Sakaguchi K, Hanaoka K, Itoh T
  • Organizer: Society of Nuclear Medicine and Molecular Imaging
  • Place of Presentation: セントルイス
• [Presentation] Therapy planning and dose prescription in radioiodine therapy for hyperthyroidism using SPECT/CT (2013)
  • Author(s): Hosono M, Hanaoka K, Ishii K, Im S, Sakaguchi K, Yagyu Y, Matsukubo Y, Ohno Y, Ikegami H
  • Organizer: European Association of Nuclear Medicine 2013
  • Place of Presentation: リヨン
• [Presentation] Association among heterogeneity of intratumoral anti-CD20 antibody distribution, glucose metabolism and therapeutic response in radioimmunotherapy for B-cell lymphoma (2013)
  • Author(s): Hosono M, Hanaoka K, Ishii K, Im S, Sakaguchi K, Yagyu Y, Komeya Y, Tsuchiya N, Tatsumi Y, Matsumura I
  • Organizer: European Association of Nuclear Medicine 2013
  • Place of Presentation: リヨン
• [Presentation] RI治療の概要 核医学基礎セミナー (2013)
  • Author(s): 細野 眞
  • Organizer: 第13回日本核医学会春季大会
  • Place of Presentation: 日本教育会館 東京都千代田区一ツ橋
  • Invited
• [Book] 新版放射線医科学 (2016)
  • Author(s): 細野 眞
  • Total Pages: 189
  • Publisher: 医療科学社
• [Book] 放射線医科学 (2016)
  • Author(s): 細野 眞
  • Publisher: 医療科学社
• [Book] 平成25年度厚生労働科学研究費補助金（地域医療基盤開発推進研究事業）「医療放射線防護に関する研究」（H24-医療-一般-017）（研究代表者：細野 眞）総括研究報告書 (2014)
  • Author(s): 細野 眞、山口一郎、高橋健夫、赤羽正章、成田雄一郎
  • Total Pages: 15
  • Publisher: 厚生労働科学研究費補助金報告
• [Book] 「核医学診療施設における濃度限度等の評価に関する検討について」 平成25年度厚生労働科学研究費補助金 地域医療基盤開発推進研究事業「医療放射線防護に関する研究」（H24-医療-一般-017）（研究代表者：細野 眞）分担研究報告書 (2014)
  • Author(s): 細野 眞、池渕秀治、中村吉秀、中村伸貴、山田崇裕、柳田幸子、北岡 麻美、宇佐美公男、坂口健太、花岡宏平、上田いづみ
  • Total Pages: 105
  • Publisher: 厚生労働科学研究費補助金報告
• [Book] 「前立腺癌患者に対してヨウ素125密封小線源永久挿入療法の適用後に帰宅した場合の治療患者以外の第三者に対する放射線安全確保に関する検討― 退出後の患者家族の被ばく線量に関する検討（実測による検討）―」 平成25年度厚生労働科学研究費補助金 地域医療基盤開発推進研究事業「医療放射線防護に関する研究」（H24-医療-一般-017）（研究代表者：細野 眞）分担研究報告書 (2014)
  • Author(s): 細野 眞、斉藤史郎、西山 徹、萬 篤憲、新谷幸子、入江香絵、門馬 のり子、高橋健夫、土器屋卓志、池渕秀治、中村吉秀、中村伸貴、山田崇裕、柳田幸子、小林育夫、関口寛、堤昭二、三村昌人、瀬ノ上裕之
  • Total Pages: 17
  • Publisher: 厚生労働科学研究費補助金報告
• [Book] 「RI内用療法に関する施設状況調査について」平成25年度厚生労働科学研究費補助金 地域医療基盤開発推進研究事業「医療放射線防護に関する研究」（H24-医療-一般-017）（研究代表者：細野 眞）分担研究報告書 (2014)
  • Author(s): 細野 眞、池渕秀治、中村吉秀、中村伸貴、柳田幸子、北岡麻美、奥 真也
  • Total Pages: 105
  • Publisher: 厚生労働科学研究費補助金報告
• [Book] 医療放射線防護の国際動向」平成25年度厚生労働科学研究費補助金 地域医療基盤開発推進研究事業「医療放射線防護に関する研究」（H24-医療-一般-017）（研究代表者：細野 眞）分担研究報告書 (2014)
  • Author(s): 細野 眞、赤羽恵一
  • Total Pages: 5
  • Publisher: 厚生労働科学研究費補助金報告
• [Book] 骨転移に対するアイソトープ治療-塩化ストロンチウム-89前立腺癌放射線治療のすべて（編集 青木学、秋元哲夫、溝脇尚志 中村和正） (2013)
  • Author(s): 細野 眞
  • Total Pages: 374
  • Publisher: 金原出版株式会社
• [Remarks] 医療放射線と未来
  • URL: http://positron.me