| Project/Area Number |
25461858
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAKEDA Shingo 産業医科大学, 医学部, 講師 (30352313)
NAKAMURA Jun 産業医科大学, 医学部, 非常勤講師 (40148804)
MORIYA Junji 産業医科大学, 医学部, 助教 (50412656)
KATSUKI Asuka 産業医科大学, 医学部, 助教 (60566488)
YOSHIMURA Reiji 産業医科大学, 医学部, 教授 (90248568)
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| Research Collaborator |
OGASAWARA Atsushi
MURAKAMI Yu
MIYATA Mari
ABE Osamu
WATANABE Keita
UEDA Issei
IGATA Ryohei
SUGIMOTO Koichiro
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 大うつ病性障害 / 遺伝子多型 / 拡散テンソル画像 / 脳MR統計画像解析 |
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| Outline of Final Research Achievements |
We assessed associations of genetic variations in catechol-O-methyltransferase (COMT) and norepinephrine transporter (NET) with brain volume in major depressive disorder (MDD) using VBM analysis of brain MRI. We recruited 30 first-episode, treatment-naïve MDD patients and 48 healthy subjects matched for age and gender; they were divided by the COMT/NET genotypes. Effects of the genotype and the genotype-diagnosis interaction in relation to brain morphology in the each group were evaluated using a VBM. In the healthy subjects, interacting functional variants in COMT affected gray matter regional volume; Val/Val individuals had smaller volume in the bilateral caudate and the posterior cingulate cortex compared to Val/Met individuals. In the MDD cases, the COMT genotype affected volume reduction in the caudate. A significant NET genotype (G1287A) - diagnosis interaction was found in the left dorsolateral prefrontal cortex, and the polymorphism of the NET gene was associated with
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