Development of large-scale production method for highly purified no-carrier-added lutetium-177 for advanced cancer therapy

• Project/Area Number: 25461861
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Japan Atomic Energy Agency
• Principal Investigator: watanabe satoshi 国立研究開発法人日本原子力研究開発機構, 原子力科学研究部門 量子ビーム応用研究センター, 研究副主幹 (40354964)
• Co-Investigator(Renkei-kenkyūsha): HASHIMOTO KAZUYUKI 国立研究開発法人日本原子力研究開発機構, 原子力科学研究部門・量子ビーム応用研究センター, 研究主幹 (80414530)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ルテチウム-177 / イッテルビウム / 抽出 / 塩酸 / HDEHP / ＨＤＥＨＰ

Outline of Final Research Achievements

We have already studied the production method of highly purified no-carrier-added Lu-177 using reversed-phase ion-pair liquid chromatography. In this study, for the development of the large-scale production of Lu-177, solvent extraction method with HDEHP (Bis(2-ethylhexyl) phosphate) for the rough separation of Yb which is incorporated before the reversed-phase ion-pair liquid chromatography was investigated. As a result, it was found that the extraction yield increased with an increase in HDEHP concentration, and that the yield increased with a decrease in HCl and Yb concentration.