Interaction of neurotransmission functions measured by PET and MRI

• Project/Area Number: 25461862
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Fukushima Medical University (2014-2015); National Institute of Radiological Sciences (2013)
• Principal Investigator: Ito Hiroshi 福島県立医科大学, ふくしま国際医療科学センター, 教授 (20360357)
• Co-Investigator(Kenkyū-buntansha): TAKANO Harumasa 放射線医学総合研究所, 分子イメージング研究センター, 室長 (30348792)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: PET / MRI / 脳 / ドーパミン / ノルエピネフリン / ニューロメラニン / ＰＥＴ / ＭＲＩ / ドーパミンD2レセプター / ドーパミン生成能 / ドーパミントランスポーター

Outline of Final Research Achievements

The central monoaminergic system is of major importance in the pathophysiology of neuropsychiatric disorders. The normal database of dopaminergic neurotransmission functions in the midbrain, consisting of neuromelanin, dopamine synthesis, dopamine transporters and dopamine D2 receptors, was constructed using magnetic resonance (MR) imaging and positron emission tomography (PET). The normal database of norepinephrinergic neurotransmission functions in the locus ceruleus, consisting of neuromelanin and norepinephrine transporters was also constructed. Neuromelanin accumulation was not correlated with dopamine synthesis capacity and dopamine transporter binding in variation for young healthy subjects. On the other hand, a positive correlation between dopamine D2 receptor binding and neuromelanin accumulation was observed, indicating a feedback mechanism by dopaminergic autoreceptors. Neuromelanin accumulation was not correlated with norepinephrine transporter binding.

Research Products

• [Journal Article] PET Quantification of Tau Pathology in Human Brain with 11C-PBB3 (2015)
  • Author(s): Yasuyuki Kimura, Masanori Ichise, Hiroshi Ito, Hitoshi Shimada, Yoko Ikoma, Chie Seki, Harumasa Takano, Soichiro Kitamura, Hitoshi Shinotoh, Kazunori Kawamura, Ming-Rong Zhang, Naruhiko Sahara, Tetsuya Suhara, Makoto Higuchi
  • Journal Title: Journal of nuclear medicine Volume: 56 Issue: 9 Pages: 1359-1365
  • DOI: 10.2967/jnumed.115.160127
  • Peer Reviewed
• [Journal Article] Evaluation of semi-quantitative method for quantification of dopamine transporter in human PET study with ¹⁸F-FE-PE2I. (2015)
  • Author(s): Ikoma Y, Sasaki T, Kimura Y, Seki C, Okubo Y, Suhara T, Ito H.
  • Journal Title: Ann Nucl Med. Volume: 29 Issue: 8 Pages: 697-708
  • DOI: 10.1007/s12149-015-0993-3
  • Peer Reviewed / Open Access
• [Journal Article] [11C]Raclopride binding in the striatum of minimally restrained and free-walking awake mice in a positron emission tomography study (2015)
  • Author(s): Takuwa H, Maeda J, Ikoma Y, Tokunaga M, Wakizaka H, Uchida S, Kanno I, Taniguchi J, Ito H, Higuchi M
  • Journal Title: Synapse Volume: 69 Issue: 12 Pages: 600-606
  • DOI: 10.1002/syn.21864
  • Peer Reviewed
• [Journal Article] 実臨床におけるPET/CT, SPECT/CTの意義と今後の展開．神経変性疾患における最新動向．神経内科領域におけるPET/CT, SPECT/CTの有用性―パーキンソン病におけるドーパミントランスポーターイメージング． (2015)
  • Author(s): 伊藤 浩、村上丈伸、石井士朗
  • Journal Title: INNERVISION Volume: 30 Pages: 19-21
• [Journal Article] Reproducibility of PET measurement for presynaptic dopaminergic functions using L-[β-(11)C]DOPA and [(18)F]FE-PE2I in humans. (2014)
  • Author(s): Suzuki M, Ito H, Kodaka F, Takano H, Kimura Y, Fujiwara H, Sasaki T, Takahata K, Nogami T, Nagashima T, Nengaki N, Kawamura K, Zhang MR, Varrone A, Halldin C, Okubo Y, Suhara T.
  • Journal Title: Nucl Med Commun. Volume: 35 Issue: 3 Pages: 231-237
  • DOI: 10.1097/mnm.0000000000000052
  • Peer Reviewed
• [Journal Article] Influence of O-methylated metabolite penetrating the blood-brain barrier to estimation of dopamine synthesis capacity in human L-[β-11C]DOPA PET. (2014)
  • Author(s): Matsubara K, Ikoma Y, Okada M, Ibaraki M, Suhara T, Kinoshita T, Ito H
  • Journal Title: J Cereb Blood Flow Metab Volume: 34 Issue: 2 Pages: 268-274
  • DOI: 10.1038/jcbfm.2013.187
  • Peer Reviewed
• [Journal Article] Norepinephrine transporter occupancy by nortriptyline in patients with depression: a positron emission tomography study with (S,S)-[¹⁸F]FMeNER-D₂. (2014)
  • Author(s): Takano H, Arakawa R, Nogami T, Suzuki M, Nagashima T, Fujiwara H, Kimura Y, Kodaka F, Takahata K, Shimada H, Murakami Y, Tateno A, Yamada M, Ito H, Kawamura K, Zhang MR, Takahashi H, Kato M, Okubo Y, Suhara T.
  • Journal Title: Int J Neuropsychopharmacol. Volume: 17 Issue: 04 Pages: 553-60
  • DOI: 10.1017/s1461145713001521
  • Peer Reviewed
• [Journal Article] Quantitative Analysis of Amyloid Deposition in Alzheimer Disease Using PET and the Radiotracer 11C-AZD2184. (2014)
  • Author(s): Ito H, Shimada H, Shinotoh H, Takano H, Sasaki T, Nogami T, Suzuki M, Nagashima T, Takahata K, Seki C, Kodaka F, Eguchi Y, Fujiwara H, Kimura Y, Hirano S, Ikoma Y, Higuchi M, Kawamura K, Fukumura T, Böö EL, Farde L, Suhara T
  • Journal Title: J Nucl Med Volume: 55 Pages: 932-938
  • Peer Reviewed
• [Journal Article] Norepinephrine in the brain is associated with aversion to financial loss (2013)
  • Author(s): Takahashi, H., Fujie, S., Camerer, C., Arakawa, R., Takano, H., Kodaka, F., Matsui, H., Ideno T, Okubo S, Takemura K., Yamada M, Eguchi Y, Murai T, Okubo Y, Kato M,Ito H, Suhara T
  • Journal Title: Molecular Psychiatry Volume: 18 Issue: 1 Pages: 3-4
  • DOI: 10.1038/mp.2012.7
  • Peer Reviewed
• [Journal Article] Test-retest reproducibility of dopamine D2/3 receptor binding in human brain measured by PET with [11C]MNPA and [11C]raclopride. (2013)
  • Author(s): Kodaka F, Ito H, Kimura Y, Fujie S, Takano H, Fujiwara H, Sasaki T, Nakayama K, Halldin C, Farde L, Suhara T
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 40 Issue: 4 Pages: 574-579
  • DOI: 10.1007/s00259-012-2312-8
  • Peer Reviewed
• [Journal Article] Noninvasive k3 estimation method for slow dissociation PET ligands: application to [11C]Pittsburgh compound B. (2013)
  • Author(s): Sato K, Fukushi K, Shinotoh H, Shimada H, Hirano S, Tanaka N, Suhara T, Irie T, Ito H
  • Journal Title: EJNMMI Res Volume: 3 Issue: 1 Pages: 76-76
  • DOI: 10.1186/2191-219x-3-76
  • Peer Reviewed
• [Journal Article] Occupancy of serotonin and norepinephrine transporter by milnacipran in patients with major depressive disorder: a positron emission tomography study with [11C]DASB and (S,S)-[18F]FMeNER-D2. (2012)
  • Author(s): Nogami T, Takano H, et al
  • Journal Title: Int J Neuropsychopharmacol. Volume: 16 Issue: 5 Pages: 1-7
  • DOI: 10.1017/s1461145712001009
  • Peer Reviewed
• [Presentation] グラフプロット法による脳レセプター測定用PETトレーサーの動態特性の視覚的評価． (2015)
  • Author(s): 伊藤 浩、生駒洋子、関 千江、木村泰之、川口拓之、田桑弘之、山谷泰賀、須原哲也、菅野 巖
  • Organizer: 第55回日本核医学会学術総会
  • Place of Presentation: 東京都
  • Year and Date: 2015-11-05
• [Presentation] Quantitative analysis of tau pathology in human brain using PET with [C-11]PBB3 (2015)
  • Author(s): Ito H, Shimada H, Ikoma Y, Shinotoh H, Kimura Y, Ichise M, Suhara T, Higuchi M
  • Organizer: SNMMI 2015 Annual Meeting
  • Place of Presentation: Baltimore
  • Year and Date: 2015-06-06
  • Int'l Joint Research
• [Presentation] [C-11]PBB3による脳内タウ病変の定量測定． (2014)
  • Author(s): 伊藤 浩、島田 斉、生駒洋子、関 千江、木村泰之、高野晴成、篠遠 仁、張 明栄、須原哲也、樋口真人
  • Organizer: 第54回日本核医学会学術総会
  • Place of Presentation: 大阪市
  • Year and Date: 2014-11-06 – 2014-11-08
• [Presentation] Visual evaluation of kinetic characteristics using a new graphic plot analysis in PET neuroreceptor imaging. (2014)
  • Author(s): Ito H, Ikoma Y, Seki C, Kimura Y, Kawaguchi H, Takuwa H, Tajima Y, Yamaya T, Suhara T, Kanno I
  • Organizer: The 10th International Symposium on Functional Neuroreceptor Mapping of the Living Brain (NRM2014)
  • Place of Presentation: Egmond aan Zee, The Netherlands
  • Year and Date: 2014-05-21 – 2014-05-24
• [Presentation] 核医学1 神経伝達機能イメージングの臨床への展開． (2013)
  • Author(s): 伊藤 浩
  • Organizer: 第72回日本医学放射線学会総会
  • Place of Presentation: 横浜市
  • Invited
• [Presentation] Changes in effective diffusivity for oxygen in the capillary bed during neural activation and deactivation measured by PET. (2013)
  • Author(s): Ito H, Ibaraki M, Takuwa H, Kawaguchi H, Masamoto K, Ikoma Y, Seki C, Kanno I
  • Organizer: The Society of Nuclear Medicine 60th Annual Meeting
  • Place of Presentation: Vancouver, Canada
• [Book] 脳画像でみる精神疾患． (2013)
  • Author(s): 伊藤 浩
  • Total Pages: 247
  • Publisher: 新興医学出版社
• [Remarks] 福島県立医科大学 ふくしま国際医療科学センター 先端臨床研究センター
  • URL: http://www.fmu.ac.jp/home/acrc/
• [Remarks] 分子イメージング研究センター/放射線医学総合研究所
  • URL: http://www.nirs.go.jp/rd/structure/mic/index.shtml