| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In the cancer treatment, selection of appropriate therapeutic drugs for the patients is difficult and then the standardized treatment is undertaken. Recently, we have developed an innovative 3D culture method of cancer cells to simulate in vivo conditions. This technique allows for the creation of uniform spheroids with easy handling, which would be useful for a drug selection (Yoshii et al. Biomaterials 2011). In this study, using this 3D culture method, we developed a novel drug screening system to select the personalized therapeutic drugs and diagnostic probes for positron emission tomography (PET) monitoring. As a result, we demonstrated that this 3D culture screening system can find drugs that effectively inhibit cancer growth in vivo. This system can also select the appropriate accompanying PET probes for therapy monitoring. Therefore, this 3D culture screening system could be a useful platform to realize precision medicine.
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