Development of a screening system to select the personalized anti-cancer drugs and diagnostic probes for PET monitoring
| Project/Area Number |
25461863
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
Yoshii Yukie 国立研究開発法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 (10397242)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | PET / 三次元培養 / 治療薬選択 / 治療モニタリング |
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| Outline of Final Research Achievements |
In the cancer treatment, selection of appropriate therapeutic drugs for the patients is difficult and then the standardized treatment is undertaken. Recently, we have developed an innovative 3D culture method of cancer cells to simulate in vivo conditions. This technique allows for the creation of uniform spheroids with easy handling, which would be useful for a drug selection (Yoshii et al. Biomaterials 2011). In this study, using this 3D culture method, we developed a novel drug screening system to select the personalized therapeutic drugs and diagnostic probes for positron emission tomography (PET) monitoring. As a result, we demonstrated that this 3D culture screening system can find drugs that effectively inhibit cancer growth in vivo. This system can also select the appropriate accompanying PET probes for therapy monitoring. Therefore, this 3D culture screening system could be a useful platform to realize precision medicine.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] High-throughput screening with nanoimprinting 3D culture for efficient drug development by mimicking the tumor environment2015
Author(s)
Yoshii Y, Furukawa T, Waki A, Okuyama H, Inoue M, Itoh M, Zhang M. R, Wakizaka H, Sogawa C, Kiyono Y, Yoshii H, Fujibayashi Y, Saga T.
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Journal Title
Biomaterials
Volume: 51
Pages: 278-289
DOI
Related Report
Peer Reviewed
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[Presentation] Development of drug screening system with nanoimprinting 3D culture to provide effective drugs in vivo and the accompanying PET probes for therapy monitoring2015
Author(s)
Yukie Yoshii, Takako Furukawa, Atsuo Waki, Manabu Itoh, Ming-Rong Zhang, Hidekatsu Wakizaka, Yasushi Kiyono, Yasuhisa Fujibayashi, Tsuneo Saga
Organizer
The Society of Nuclear Medicine (SNM) annual meeting 2015
Place of Presentation
Baltimore, MD, USA
Year and Date
2015-06-06 – 2015-06-10
Related Report
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