| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Outline of Final Research Achievements |
Heart and cerebrovascular diseases, which are attributed mainly to arteriosclerosis, are major causes of death in Japan. Improvement in the diagnosis and treatment of arteriosclerosis is a pressing issue. The WHHLMI rabbit is an animal model for spontaneous myocardial infarction due to arteriosclerosis and expected to be a useful model animal for preclinical research of arteriosclerosis. However, the pathological condition of WHHLMI rabbits is still not fully understood. We developed an MRI system for noninvasive in vivo evaluation of cardiac function in rabbits in order to reveal the pathological condition of myocardial infarction in WHHLMI rabbits. The results suggested the cardiac depression in WHHLMI rabbits. WHHLMI rabbits will be useful for preclinical research of arteriosclerosis.
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