Revealing the pathological condition of a rabbit model for spontaneous myocardial infarction (WHHLMI rabbit) using MRI
Project/Area Number |
25461867
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | National Cardiovascular Center Research Institute |
Principal Investigator |
Enmi Jun-ichiro 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員 (80393205)
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Research Collaborator |
SHIOMI Masashi
SATO Hiroshi
NAKAO Kazuhiro
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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Keywords | 動脈硬化 / プラーク / WHHLMI / 画像診断 / MRI |
Outline of Final Research Achievements |
Heart and cerebrovascular diseases, which are attributed mainly to arteriosclerosis, are major causes of death in Japan. Improvement in the diagnosis and treatment of arteriosclerosis is a pressing issue. The WHHLMI rabbit is an animal model for spontaneous myocardial infarction due to arteriosclerosis and expected to be a useful model animal for preclinical research of arteriosclerosis. However, the pathological condition of WHHLMI rabbits is still not fully understood. We developed an MRI system for noninvasive in vivo evaluation of cardiac function in rabbits in order to reveal the pathological condition of myocardial infarction in WHHLMI rabbits. The results suggested the cardiac depression in WHHLMI rabbits. WHHLMI rabbits will be useful for preclinical research of arteriosclerosis.
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Report
(5 results)
Research Products
(20 results)
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[Journal Article] Development of in vivo tissue-engineered microvascular grafts with an ultra small diameter of 0.6 mm (MicroBiotubes): acute phase evaluation by optical coherence tomography and magnetic resonance angiography.2016
Author(s)
Ishii D, Enmi J, Moriwaki T, Ishibashi-Ueda H, Kobayashi M, Iwana S, Iida H, Satow T, Takahashi JC, Kurisu K, Nakayama Y
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Journal Title
Journal of Artificial Organs
Volume: 19
Pages: 262-269
DOI
Related Report
Peer Reviewed
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[Journal Article] A novel mouse model of subcortical infarcts with dementia.2015
Author(s)
Hattori Y, Enmi J, Kitamura A, Yamamoto Y, Saito S, Takahashi Y, Iguchi S, Tsuji M, Yamahara K, Nagatsuka K, Iida H, Ihara M
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Journal Title
The Journal of Neuroscience
Volume: 35
Pages: 3915-3928
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Validity of using a 3-dimensional PET scanner during inhalation of 15O-labeled oxygen for quantitative assessment of regional metabolic rate of oxygen in man.2014
Author(s)
Hori Y, Hirano Y, Koshino K, Moriguchi T, Iguchi S, Yamamoto A, Enmi J, Kawashima H, Zeniya T, Morita N, Nakagawara J, Casey ME, Iida H
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Journal Title
Physics in Medicine and Biology
Volume: 59
Pages: 5593-5609
DOI
Related Report
Peer Reviewed
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[Journal Article] Adequacy of a compartment model for CMRO2 quantitation using 15O-labeled oxygen and PET: a clearance measurement of 15O-radioactivity following intracarotid bolus injection of 15O-labeled oxyhemoglobin on Macaca fascicularis.2014
Author(s)
Iida H, Iguchi S, Teramoto N, Koshino K, Zeniya T, Yamamoto A, Kudomi N, Moriguchi T, Hori Y, Enmi J, Kawashima H, Joni Shah N, Nakagawara J
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Journal Title
Journal of Cerebral Blood Flow & Metabolism
Volume: 34
Pages: 1434-1439
DOI
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Peer Reviewed / Open Access
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[Presentation] Imaging and histopathological analyses of aortic lesions in atherosclerosis model mice using MRI2013
Author(s)
Eiko Shibata, Jun-ichiro Enmi, Masa-Aki Shibata, Megumu Morimoto, Hajime Fukuda, Yoshiko Hashikawa, Satoshi Iguchi, Hidekazu Kawashima, Masahito Michikura, Chizuru Fuke, Mika Hori, Hidehiro Iida, Mariko Harada-Shiba
Organizer
第45回日本動脈硬化学会総会・学術集会
Place of Presentation
新宿
Year and Date
20130718-20130719
Related Report
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