| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
Hematopoietic stem cell transplantation is a powerful treatment that can be used to reconstitute hematopoietic systems damaged by accidental exposure to a lethal dose of radiation. Although umbilical cord blood cells (UCBCs) are an excellent transplant source, only a small number of cells can be obtained from a single umbilical cord. Mixed UCBC transplantation can overcome this limitation. In the present study using a murine model, we examined whether mixed UCBC transplantation would be suitable for radiation emergency medicine. Interestingly, a higher life-saving effect was obtained when allogeneic cord blood sources were mixed. In addition, such allogeneic mixed UCBC transplantation had the effect of restoring the recipient’s own hematopoietic system after exposure to a lethal dose of radiation. These results suggest the effectiveness of allogeneic umbilical cord blood as a source for mixed UCBC transplantation at centers specializing in radiation emergency medicine.
|
