Establishment of effective mixed umbilical cord blood transplantation for lethal dose radiation exposure
| Project/Area Number |
25461868
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hirosaki University |
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Principal Investigator |
Ito Koichi 弘前大学, 保健学研究科, 教授 (90398579)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANO Manabu 弘前大学, 保健学研究科, 助教 (10436016)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 被ばく医療 / 臍帯血移植 / 免疫系再構築 / 放射線被ばく医療 / 混合臍帯血移植 / 放射線被ばく / 組織適合性抗原 / 造血幹細胞 |
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| Outline of Final Research Achievements |
Hematopoietic stem cell transplantation is a powerful treatment that can be used to reconstitute hematopoietic systems damaged by accidental exposure to a lethal dose of radiation. Although umbilical cord blood cells (UCBCs) are an excellent transplant source, only a small number of cells can be obtained from a single umbilical cord. Mixed UCBC transplantation can overcome this limitation. In the present study using a murine model, we examined whether mixed UCBC transplantation would be suitable for radiation emergency medicine. Interestingly, a higher life-saving effect was obtained when allogeneic cord blood sources were mixed. In addition, such allogeneic mixed UCBC transplantation had the effect of restoring the recipient’s own hematopoietic system after exposure to a lethal dose of radiation. These results suggest the effectiveness of allogeneic umbilical cord blood as a source for mixed UCBC transplantation at centers specializing in radiation emergency medicine.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Mitigative Effects of a Combination of Multiple Pharmaceutical Drugs on the Survival of Mice Exposed to Lethal Ionizing Radiation2016
Author(s)
Hirouchi T, Ito K, Nakano M, Monzen S, Yoshino H, Chiba M, Hazawa M, Nakano A, Ishikawa J, Yamaguchi M, Tanaka K, Kashiwakura I
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Journal Title
Curr Pharm Biotechnol.
Volume: 17
Issue: 2
Pages: 190-199
DOI
Related Report
Peer Reviewed / Open Access
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