Development of a practical microreactor synthesys method of 11C-probes
| Project/Area Number |
25461870
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
ISHIKAWA Yoichi 東北大学, サイクロトロン・ラジオアイソトープセンター, 助手 (60361200)
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| Co-Investigator(Kenkyū-buntansha) |
IWATA Ren 東北大学, サイクロトロン・ラジオアイソトープセンター, 名誉教授 (60143038)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | マイクロリアクター合成 / 分子イメージング / PET / 分子プローブ / 自動合成 / methyl triflate / Radiosynthesys / PET probe / Radiosynthesis |
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| Outline of Final Research Achievements |
A rapid automated microreactor system was developed for 11C-methylation with 11C-methyl triflate (11C-MT). 11C-MT was flowed through a small diameter tube where it was trapped by thermoelectric cooling. It was then released and recovered with a small volume of suitable solvent such as acetone or acetonitrile. The 11C-MT was thus concentrated in a good recovery yield with optimized conditions and successfully applied to microreactor preparation of 11C-raclopride.
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Report
(4 results)
Research Products
(10 results)
