| Project/Area Number |
25461872
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
Koda Wataru 金沢大学, 医学系, 准教授 (30401920)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUI Osamu 金沢大学, 医薬保健学総合研究科, 特任教授 (10019961)
MINAMI Tetsuya 金沢大学, 附属病院, 准教授 (60436813)
YOSHIDA Kotaro 金沢大学, 医学系, 助教 (30645130)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | インターベンショナルラジオロジー（IVR） / 癌 / 血管透過性 / 肝臓 / ミクロ粒子 |
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| Outline of Final Research Achievements |
To develop specific, effective and non-invasive delivery system using IVR technology, we investigated the relationship of vasoactive substances to vascular permeability. By photoacoustic imaging, it was possible to confirm the kinetics of indocyanine green (ICG) and ICG uptake into the cells. In addition, the tissue accumulation of Evans blue was enhanced in the state of increased vascular permeability, and the signal of a photoacoustic imaging by ICG was reduced in the state of decreased vascular permeability.
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