New method to estimate brain damage and altered brain function due to radiotherapy in the patients with brain metastasis

• Project/Area Number: 25461900
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hirosaki University
• Principal Investigator: Mariya Yasushi 弘前大学, 保健学研究科, 教授 (20239148)
• Co-Investigator(Kenkyū-buntansha): TAKAI Yoshihiro 弘前大学, 大学院医学研究科, 教授 (50107653) ; TSUSHIMA Megumi 弘前大学, 大学院保健学研究科, 助教 (90592254) ; YOSHIDA Hideki 弘前大学, 大学院保健学研究科, 准教授 (20400145)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 脳血流機能画像 / 脳転移 / 放射線治療 / 脳血流低下 / 認知機能低下 / 全脳照射 / 転移性脳腫瘍 / 認知機能 / 脳有害事象

Outline of Final Research Achievements

We investigated the availability of stereotactic statistical analysis of brain perfusion SPECT using 3-dimensional stereotactic surface projections (3D-SSP) to estimate the influence of radiation on brain function. The subjects were 12 with brain metastases. Whole brain, partial brain, and stereotactic radiotherapy (WBRT, PBRT and SRT) were delivered. Before and after radiotherapy, MRI, 3D-SSP and mini-mental state examination (MMSE) were performed. Regional cerebral blood flow (rCBF) decreased in the areas of tumor. For 6, 3D-SSP and MMSE were serially analyzed. Two of the 4 who received WBRT showed diffusely decreased rCBF, as well as decreased MMSE score. The remnant 2 showed no changes for both. One who received PBRT showed decreased rCBF, but the MMSE score was maintained. The other receiving SRT showed no change in rCBF, though the MMSE score decreased. Radiotherapy possibly has a risk to decrease rCBF, detected by 3D-SSP analysis.

Research Products

• [Int'l Joint Research] Stockholm University(Sweden)
• [Journal Article] Application of cell sorting for enhancing the performance of the cytokinesis-block micronucleus assay (2016)
  • Author(s): Nakamura A, Monzen S, Takasugi Y, Wojcik A, Mariya Y
  • Journal Title: J Radiat Res. Volume: 57(2) Issue: 2 Pages: 121-126
  • DOI: 10.1093/jrr/rrv103
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The predictive factors of cytotoxic damage in radioactive iodine treatment of differentiated thyroid cancer patients，Molecular and Clinical Oncology (2015)
  • Author(s): Monzen S, Mariya Y, Wojcik A, Kawamura C, Nakamura A, Chiba M, Hosoda M, Takai Y.
  • Journal Title: Mol Clin Oncol. Volume: 3 Issue: 3 Pages: 692-698
  • DOI: 10.3892/mco.2015.499
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cytogenetic dosimetry by micronucleus assay using peripheral blood cells is modified by thyroid hormones (2015)
  • Author(s): Monzen S, Mariya Y, Nakamura A, Kawamura C, Taira K, Chiba M, Takai Y
  • Journal Title: Radiat Prot Dosimetry. Volume: 167(1-3) Issue: 1-3 Pages: 321-325
  • DOI: 10.1093/rpd/ncv271
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 超音波エラストグラフィを用いた乳房温存手術後の放射線治療による乳房線維化の評価 (2015)
  • Author(s): 對馬 惠、真里谷 靖、高井 良尋
  • Journal Title: 臨床放射線 Volume: 60 Pages: 823-831
  • NAID: 40020512321
  • Peer Reviewed
• [Journal Article] 放射線治療前後の脳血流機能画像および認知機能を評価できた転移性腫瘍の２例 (2013)
  • Author(s): 對馬惠、真里谷靖、高井良尋、高橋大樹
  • Journal Title: 臨床放射線 Volume: 58 Pages: 1363-1368
  • Peer Reviewed
• [Presentation] Stereotactic statistical analysis of brain perfusion SPECT using 3-dimensional stereotactic surface projections to estimate brain function of the patients harboring brain metastases before and after radiotherapy. (2015)
  • Author(s): Mariya Y
  • Organizer: ESMO ASIA 2015
  • Place of Presentation: Singapore (Singapore)
  • Year and Date: 2015-12-18
  • Int'l Joint Research
• [Presentation] リコピン含有トマトジュースによる放射線防護効果の探索 (2015)
  • Author(s): 中村 歩美、真里谷 靖、Hghdoost Siamak
  • Organizer: 日本放射線影響学会放射線ワークショップ
  • Place of Presentation: 富山大学（富山、富山）
  • Year and Date: 2015-10-16
• [Presentation] Investigation of the radioprotective effect of tomato juice containing lycopene in healthy donors. (2015)
  • Author(s): Nakamura A, Fujishima Y, Fukushi Y, Kitajima M, Monzen S, Miura T, Saito A, Yonezawa T, Suganuma H, Aizawa K, Itaki C, Yoshida M, Wojcik A, Mariya Y, Haghdoost S.
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto International Conference Center (Kyoto, Kyoto)
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Availability of oxidative stress-related marker to estimate radiation damage in the thyroid cancer patients undergoing 131-I treatment. (2015)
  • Author(s): Mariya Y, Kawamura C, Nakamura A, Monzen S, Takai Y, Saito A, Yonezawa T.
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto International Conference Center (Kyoto, Kyoto)
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Cytotoxic damage of peripheral blood cells by 131-I treatment of differentiated thyroid cancer patients. (2015)
  • Author(s): Monzen S, Mariya Y, Wojcik A, Takai Y.
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto International Conference Center (Kyoto, Kyoto)
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] 脳血流機能画像による脳転移放射線治療患者の脳機能解析 (2013)
  • Author(s): 真里谷靖、對馬惠、高井良尋
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: ホテル青森(青森県青森市）