Development for a next-generation BNCT treatment planning system by combination with micro-dosimetry method

• Project/Area Number: 25461901
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: University of Tsukuba
• Principal Investigator: Kumada Hiroaki 筑波大学, 医学医療系, 准教授 (30354913)
• Co-Investigator(Kenkyū-buntansha): Sakurai Hideyuki 筑波大学, 医学医療系, 教授 (50235222) ; Sakae Takeji 筑波大学, 医学医療系, 教授 (60162278) ; Matsumura Akira 筑波大学, 副学長 (90241819)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 治療計画 / ホウ素中性子捕捉療法 / モンテカルロ法 / マイクロドシメトリ / 粒子線治療 / 中性子線 / 中性子法則療法 / 中性子捕捉療法

Outline of Final Research Achievements

A prototype system for next-generation treatment planning system for boron neutron capture therapy (BNCT) has been developed. The system can estimate doses determined by combination with micro-dosimetry technology and Monte-Carlo dose calculation method. We performed verification for the system. The verification results demonstrated that the system can determine doses given to a patient by neutron irradiation in BNCT precisely.
The outcomes were presented in some congress for BNCT, and some peer-review reports for the developments have been described and published. And some patents for the inventions have been also applied.

Research Products

• [Journal Article] Verification of nuclear data for the Tsukuba plan, a newly developed treatment planning system for boron neutron capture therapy (2015)
  • Author(s): Kumada, H., Takada, K., Yamanashi, K., et al.,
  • Journal Title: Applied Radiation and Isotopes Volume: 106 Pages: 111-115
  • DOI: 10.1016/j.apradiso.2015.08.032
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Development of beryllium-based neutron target system with three-layer structure for accelerator-based neutron source for boron neutron capture therapy (2015)
  • Author(s): Kumada, H., Hurihara, T., Yoshioka, M., et al.,
  • Journal Title: Applied Radiation and Isotopes Volume: 106 Pages: 78-83
  • DOI: 10.1016/j.apradiso.2015.07.033
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Fatal carotid blow out syndrome after BNCT for head and neck cancers (2015)
  • Author(s): Aihara, T., Hiratsuka, J., Isikawa, H., Kumada, H., et al.,
  • Journal Title: Applied Radiation and Isotopes Volume: 106 Pages: 202-206
• [Journal Article] BNCTの線量評価/治療計画 (2015)
  • Author(s): 熊田博明
  • Journal Title: RADIOISOTOPES Volume: 64 Pages: 37-46
  • NAID: 130004803065
  • Peer Reviewed / Open Access
• [Journal Article] Project of development of the linac based NCT facility in University of Tsukuba (2014)
  • Author(s): H. Kumada, A. Matsumura, H.Sakkurai, et al.
  • Journal Title: Applied Radiation and Isotopes Volume: Web First Pages: 1-5
  • DOI: 10.1016/j.apradiso.2014.02.018
  • Peer Reviewed / Open Access
• [Journal Article] BNCT for advanced or recurrent head and neck cancer (2014)
  • Author(s): Aihara Teruhito, Morita Norimasa, Kamitani Nobuhiko, Kumada Hiroaki, Ono Koji, Hiratsuka Junichi, Harada Tamotsu.
  • Journal Title: Applied Radiation and Isotopes Volume: 88 Pages: 12-15
  • DOI: 10.1016/j.apradiso.2014.04.007
  • Peer Reviewed / Open Access
• [Journal Article] Correlation between radiation dose and histopathological findings in patients with gliblastoma treated with boron neutron capture therapy (BNCT) (2014)
  • Author(s): T. Kageji, Y. Mizobuchi, S. Nagahiro, Y. Nakagawa, H. Kumada
  • Journal Title: Applied Radiation and Isotopes Volume: 88 Pages: 20-22
  • DOI: 10.1016/j.apradiso.2013.12.014
  • Peer Reviewed / Open Access
• [Journal Article] Estimation of relative biological effectiveness for boron neutron capture therapy using the PHITS code coupled with a microdosimetric kinetic model (2014)
  • Author(s): H. Horiguchi, T. Sato, H. Kumada, T. Yamamoto, T. Sakae
  • Journal Title: Journal of Radiation Research Volume: 2014 Issue: 2 Pages: 1-9
  • DOI: 10.1093/jrr/rru109
  • NAID: 120007130270
  • Peer Reviewed / Open Access
• [Journal Article] WHOLE-BODY DOSE EVALUATION WITH AN ADAPTIVE TREATMENT PLANNING SYSTEM FOR BORON NEUTRON CAPTURE THERAPY (2014)
  • Author(s): K. Takada, H. Kumada, T. Isobe, et al.
  • Journal Title: Radiation Protection Dosimetry Volume: 357 Issue: 4 Pages: 1-8
  • DOI: 10.1093/rpd/ncu357
  • Peer Reviewed / Open Access
• [Journal Article] 加速器ベースBNCT治療装置の開発におけるPHITS技術の適用 (2014)
  • Author(s): 熊田博明
  • Journal Title: RIST NEWS Volume: 56 Pages: 12-24
• [Journal Article] 加速器中性子源の研究開発によるBNCTの確立に向けて (2013)
  • Author(s): 熊田博明
  • Journal Title: Jpn.J.Med.Phys Volume: Vol3.No.3 Pages: 104-110
  • NAID: 130003397834
  • Peer Reviewed
• [Journal Article] 新規ニーズ開拓・先端的放射線治療分野 (2013)
  • Author(s): 熊田博明
  • Journal Title: バイオサイエンスとインダストリー Volume: Vol3,No.3 Pages: 63-66
• [Journal Article] 小型加速器ベースの中性子捕捉療法用治療装置の開発 (2013)
  • Author(s): 熊田博明
  • Journal Title: 産学官連携ジャーナル Volume: Vol9,No.4 Pages: 78-81
• [Presentation] Development of the accelerator-based neutron source for BNCT in University of Tsukuba (2015)
  • Author(s): Hiroaki Kumada
  • Organizer: The Pacifichem 2015
  • Place of Presentation: Honolulu, USA, シェラトンホテル・ホノルル
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] 筑波大学の加速器BNCT プロジェクトの進捗状況 (2015)
  • Author(s): 熊田博明、吉岡正和、松本浩、照沼利之、他
  • Organizer: 平成27年度京都大学原子炉実験所専門研究会
  • Place of Presentation: 大阪、京都大学原子炉実験所
  • Year and Date: 2015-11-10
• [Presentation] 筑波大学の加速器BNCTプロジェクトの進捗状況 (2015)
  • Author(s): 熊田博明、松村明、榮武二、櫻井英幸、他
  • Organizer: 第110回日本医学物理学会学術大会
  • Place of Presentation: 札幌、北海道大学
  • Year and Date: 2015-09-18
  • Invited
• [Presentation] Development status of a linac-based neutron source for BNCT in University of Tsukuba (2015)
  • Author(s): Hiroaki Kumada
  • Organizer: 8th Young BNCT International Meeting
  • Place of Presentation: パヴィア、イタリア、パヴィア大学、
  • Year and Date: 2015-09-14
  • Int'l Joint Research
• [Presentation] 治療計画・線量評価・QA／QCの標準化について 「BNCTにおける治療計画の標準化について」 (2015)
  • Author(s): 熊田博明、櫻井良憲
  • Organizer: 第13回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 神戸、神戸学院大学
  • Year and Date: 2015-09-04
• [Presentation] BNCT用モンテカルロ治療計画システムの開発 (2015)
  • Author(s): 熊田博明
  • Organizer: 日本原子力学会2015年春の年会
  • Place of Presentation: 茨城大学／日立市
  • Year and Date: 2015-03-20 – 2015-03-22
  • Invited
• [Presentation] BNCTにおける線量評価/治療計画の標準化に向けて (2014)
  • Author(s): 熊田博明
  • Organizer: 日本中性子捕捉療法学会学術大会
  • Place of Presentation: 大阪大学/大阪府
  • Year and Date: 2014-07-05 – 2014-07-06
• [Presentation] Verification of Tsukuba Plan, a new treatment planning system for BNCT (2014)
  • Author(s): H. Kumada, K. Takada, T. Sakae, A. Matsumura, H. Sakurai
  • Organizer: 16th International Congress of Neutron Capture Therapy
  • Place of Presentation: ヘルシンキ／フィンランド
  • Year and Date: 2014-06-15 – 2014-06-19
• [Presentation] 筑波大学のBNCT用加速器中性子源の開発 (2014)
  • Author(s): 熊田博明
  • Organizer: 第7回Quantum Medicine 研究会
  • Place of Presentation: 水戸
• [Presentation] BNCT線量分布最適化プログラムの現状 (2013)
  • Author(s): 熊田博明、松村明、櫻井英幸、榮武二、他
  • Organizer: 日本中性子捕捉療法学会第10回学術大会
  • Place of Presentation: 岡山市
• [Presentation] BNCTの線量評価・治療計画の標準化について (2013)
  • Author(s): 熊田博明
  • Organizer: 日本中性子捕捉療法学会第10回学術大会
  • Place of Presentation: 岡山市
  • Invited
• [Presentation] Current status of the development of the linac based BNCT facility of University of Tsukuba (2013)
  • Author(s): H. Kumada, A. Matsumura, H. Sakurai, et al.
  • Organizer: 7th Young BNCT Research Meeting
  • Place of Presentation: グラナダ／スペイン
• [Presentation] 筑波大学加速器BNCT計画の現状 (2013)
  • Author(s): 熊田博明、松村明、櫻井英幸、榮武二、他
  • Organizer: 平成25年度京都大学原子炉実験所専門研究会
  • Place of Presentation: 大阪府熊取
• [Book] 放射線治療物理学 (2016)
  • Author(s): 荒木不次男、小澤修一、齋藤明登、熊田博明、他
  • Total Pages: 319
  • Publisher: 国際文献社
• [Book] Comprehensive Biomedical Physics (2014)
  • Author(s): Hiroaki Kumada
  • Total Pages: 4056
  • Publisher: Elsevier
• [Book] 原子力・量子・核融合事典 (2014)
  • Author(s): 熊田博明
  • Total Pages: 1600
  • Publisher: 丸善出版
• [Book] Chapter 6.1, Comprehensive Biomedical Physics (2014)
  • Author(s): H. Kumada et al.,
  • Total Pages: 5384
  • Publisher: Elsevier
• [Patent(Industrial Property Rights)] 患者の位置決め装置、方法及びプログラム (2015)
  • Inventor(s): 照沼利之、熊田博明、
  • Industrial Property Rights Holder: 照沼利之、熊田博明、
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-159164
  • Filing Date: 2015-08-11
• [Patent(Industrial Property Rights)] 生体試料の分解容器及び前処理装置 (2015)
  • Inventor(s): 松江登久、森本隆夫、伴場滋、熊田博明、他
  • Industrial Property Rights Holder: 松江登久、森本隆夫、伴場滋、熊田博明、他
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-179618
  • Filing Date: 2015-09-11