synchrotoron micro beam irradiation for tumors and normar tissue
Project/Area Number |
25461915
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Kobe University |
Principal Investigator |
Nishimura Hideki 神戸大学, 医学(系)研究科(研究院), 准教授 (80444610)
|
Co-Investigator(Kenkyū-buntansha) |
SASAKI Ryohei 神戸大学, 医学部附属病院, 教授 (30346267)
吉田 賢史 神戸大学, 医学部附属病院, 講師 (80351906)
|
Co-Investigator(Renkei-kenkyūsha) |
YOSHIDA Kenji 神戸大学, 医学部附属病院, 講師 (80351906)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | Spring-8 / 格子状照射 / マイクロビーム / 放射線治療 / 放射光 / Spring-8 |
Outline of Final Research Achievements |
Micro beam radiation therapy (MRT) allows for extremely high-dose irradiation. However, the toxicity of MRT in central nervous system (CNS) is still unknown. We evaluated mortality in normal mice following CNS-targeted MRT. MRT using synchrotron X-ray beam was performed using BL28B2 beam-line at the SPring-8 facility. Fifty percent lethal dose by the 300 micrometer spacing MRT was 600 Gy. Our results indicated that the MRT enable to deliver extremely high doses without loss of normal brain function. Our results suggest that normal tissue damage in MRT is related to the valley dose in regardless of the peak dose and peak valley dose ratio.
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Report
(4 results)
Research Products
(7 results)
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[Presentation] CYBERKNIFE RADIOTHERAPY FOR RECURRENT HEAD AND NECK CANCERS2014
Author(s)
Hideki Nishimura, Hiroshi Mayahara, Aya Harada, et al.
Organizer
IFHNOS(International Federation of Head and Neck Oncologic Societies) 5th World Congress / 2014 AHNS(American Head and Neck Society) Annual Meeting
Place of Presentation
New York, NY, USA
Year and Date
2014-07-26 – 2014-07-30
Related Report
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