synchrotoron micro beam irradiation for tumors and normar tissue

• Project/Area Number: 25461915
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: Nishimura Hideki 神戸大学, 医学(系)研究科(研究院), 准教授 (80444610)
• Co-Investigator(Kenkyū-buntansha): SASAKI Ryohei 神戸大学, 医学部附属病院, 教授 (30346267) ; 吉田 賢史 神戸大学, 医学部附属病院, 講師 (80351906)
• Co-Investigator(Renkei-kenkyūsha): YOSHIDA Kenji 神戸大学, 医学部附属病院, 講師 (80351906)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: Spring－8 / 格子状照射 / マイクロビーム / 放射線治療 / 放射光 / Spring-8

Outline of Final Research Achievements

Micro beam radiation therapy (MRT) allows for extremely high-dose irradiation. However, the toxicity of MRT in central nervous system (CNS) is still unknown. We evaluated mortality in normal mice following CNS-targeted MRT. MRT using synchrotron X-ray beam was performed using BL28B2 beam-line at the SPring-8 facility. Fifty percent lethal dose by the 300 micrometer spacing MRT was 600 Gy. Our results indicated that the MRT enable to deliver extremely high doses without loss of normal brain function. Our results suggest that normal tissue damage in MRT is related to the valley dose in regardless of the peak dose and peak valley dose ratio.

Research Products

• [Journal Article] Effect of heterogeneity correction on dosimetric parameters of radiotherapy planning for thoracic esophageal cancer. (2013)
  • Author(s): Nakayama M, Yoshida K, Nishimura H, Miyawaki D, Uehara K, Okamoto Y, Okayama T, Sasaki R.
  • Journal Title: Med Dosim. Volume: 39(1) Issue: 1 Pages: 31-3
  • DOI: 10.1016/j.meddos.2013.09.001
  • Peer Reviewed / Open Access
• [Journal Article] True Beamを用いた高精度エックス線治療の特徴と今後の展開 (2013)
  • Author(s): 西村英輝、上原和之、尾方俊至
  • Journal Title: Rad Fan Volume: 11 Pages: 57-59
• [Presentation] Cyberknife: Real Time Image Guided Radiation Therapy for Lung Cancer (2016)
  • Author(s): 西村英輝
  • Organizer: 第1回 アジア・オセアニア呼吸機能イメージングワークショップ
  • Place of Presentation: 兵庫県立淡路夢舞台国際会議場
  • Year and Date: 2016-01-29
  • Int'l Joint Research / Invited
• [Presentation] Effects of the synchrotron X-ray microbeam spacing on mouse normal brain tissue (2015)
  • Author(s): 中山雅央、椋本成俊、赤坂浩亮、宮脇大輔、西村英輝、梅谷啓二、近藤威、佐々木良平
  • Organizer: 日本放射線腫瘍学会第28回学術大会
  • Place of Presentation: ベイシア文化ホール(群馬県前橋市)
  • Year and Date: 2015-11-19
• [Presentation] TomoTherapy and CyberKnife - The New Era of Radiation Treatment for Head and Neck Malignancies (2015)
  • Author(s): 西村英輝
  • Organizer: 第39回日本頭頸部癌学会・第4回アジア頭頸部癌学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2015-06-03
  • Int'l Joint Research / Invited
• [Presentation] CYBERKNIFE RADIOTHERAPY FOR RECURRENT HEAD AND NECK CANCERS (2014)
  • Author(s): Hideki Nishimura, Hiroshi Mayahara, Aya Harada, et al.
  • Organizer: IFHNOS(International Federation of Head and Neck Oncologic Societies) 5th World Congress / 2014 AHNS(American Head and Neck Society) Annual Meeting
  • Place of Presentation: New York, NY, USA
  • Year and Date: 2014-07-26 – 2014-07-30
• [Presentation] Dosimetric analysis of SBRT for hepatic tumors using Varian TrueBeam and flattening filter free beams (2014)
  • Author(s): 西村 英輝、上原 和之、馬屋原 博 et al
  • Organizer: 第73回日本医学放射線学会総会
  • Place of Presentation: 横浜