Development of treatment planning system for neck node metastases

• Project/Area Number: 25461918
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kumamoto University
• Principal Investigator: MURAKAMI RYUJI 熊本大学, 大学院生命科学研究部, 教授 (90295147)
• Co-Investigator(Kenkyū-buntansha): HIRAI Toshinori 宮崎大学, 医学部, 教授 (40274724) ; UCHIYAMA Yoshikazu 熊本大学, 大学院生命科学研究部, 准教授 (50325172) ; TOYA Ryo 熊本大学, 医学部附属病院, 講師 (60452893) ; NAKAYAMA Hideki 熊本大学, 大学院生命科学研究部, 教授 (70381001) ; MURAKAMI Daizo 熊本大学, 医学部附属病院, 助教 (70398212) ; YAGI Masakazu 大阪大学, 国際医工情報センター, 特任准教授 (40362686) ; YAMASAKI Toshihiko 東京大学, 大学院情報理工学系研究科, 准教授 (70376599)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 頭頸部癌 / 頸部リンパ節転移 / 所属リンパ節区分 / 予後予測因子 / コンピュータ支援 / 予防的頸部郭清術 / 全頸部照射 / 頭頸部腫瘍 / 画像診断

Outline of Final Research Achievements

To decide the treatment areas for neck node metastases, we assessed nodal involvements based on the neck node level and elucidated the distribution from each site of head-and-neck cancers. The extensive nodal involvement at uncommon levels was a sign of disease progression. The finding of extensive nodal involvement was one of the important predictors of survival. Concerning the computer technology, we devised 3D segmentation for tumor and normal organs, differentiation using luminance distribution, and multivariate-analysis for survival. The combination of these medical findings and computer technologies can contribute to accurate diagnosis of neck node metastases and should be applied for treatment planning system providing the standard treatment areas.

Research Products

• [Journal Article] Radiation therapy for nasopharyngeal carcinoma: Predictive value of interim survival assessment (2016)
  • Author(s): Toya R, Murakami R, Saito T, Murakami D, Matsuyama T, Baba Y, Nishimura R, Hirai T, Semba A, Yumoto E, Yamashita Y, Oya N
  • Journal Title: Journal of Radiation Research Volume: 印刷中
  • Peer Reviewed / Open Access
• [Journal Article] An oncofetal antigen, IMP-3-derived long peptides induce immune responses of both helper T cells and CTLs (2016)
  • Author(s): M. Hirayama, Y. Tomita, A. Yuno, H. Tsukamoto, S. Sejju, Y. Imamura, M. A. Sayem, A. Irie, Y. Yoshitake, D. Fukuma, M. Shinohara, A. Hamada, H. Jono, E. Yuba, K. Kono, K. Yoshida, T. Tsunoda, H. Nakayama, Y. Nishimura
  • Journal Title: OncoImmunology Volume: 5 Issue: 6 Pages: e1123368-e1123368
  • DOI: 10.1080/2162402x.2015.1123368
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The tumour stromal features are associated with resistance to 5-FU-based chemoradiotherapy and a poor prognosis in patients with oral squamous cell carcinoma. (2015)
  • Author(s): Matsuoka Y, Yoshida R, Nakayama H, Nagata M, Hirosue A, Tanaka T, Kawahara K, Nakagawa Y, Sakata J, Arita H, Hiraki A, Shinohara M.
  • Journal Title: APMIS Volume: 3 Issue: 3 Pages: 205-14
  • DOI: 10.1111/apm.12344
  • Peer Reviewed / Open Access
• [Journal Article] Intrinsic TGF-β2-triggered SDF-1-CXCR4 signaling axis is crucial for drug resistance and a slow-cycling state in bone marrow-disseminated tumor cells. (2015)
  • Author(s): Nakamura T, Shinriki S, Jono H, Guo J, Ueda M, Hayashi M, Yamashita S, Zijlstra A, Nakayama H, Hiraki A, Shinohara M, Ando Y.
  • Journal Title: Oncotarget Volume: 6 Issue: 2 Pages: 1008-19
  • DOI: 10.18632/oncotarget.2826
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Osteopontin-integrin α(v)β(3) axis is crucial for 5-fluorouracil resistance in oral squamous cell carcinoma. (2015)
  • Author(s): Nakamura T, Shinriki S, Jono H, Ueda M, Nagata M, Guo J, Hayashi M, Yoshida R, Ota T, Ota K, Kawahara K, Nakagawa Y, Yamashita S, Nakayama H, Hiraki A, Shinohara M, Ando Y.
  • Journal Title: FEBS Lett Volume: 589 Issue: 2 Pages: 231-239
  • DOI: 10.1016/j.febslet.2014.12.004
  • Peer Reviewed / Open Access
• [Journal Article] Phase II clinical trial of multiple peptide vaccination for advanced head and neck cancer patients revealed induction of immune responses and improved OS (2015)
  • Author(s): Yoshitake, Y., Fukuma, D., Yuno, A., Hirayama, M., Nakayama, H., Tanaka. T., Nagata, M., Takamune, Y., Kawahara, K., Nakagawa, Y., Yoshida, R., Hirosue, A., Ogi, H., Hiraki, A. , Jono, H., Hamada, A., Yoshida, K., Nishimura, Y., Nakamura, Y., Shinohara, M.
  • Journal Title: Clinical Cancer Research Volume: 21 Issue: 2 Pages: 312-321
  • DOI: 10.1158/1078-0432.ccr-14-0202
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A clinicostatistical study of 73 patients with intraoral minor salivary gland tumors (2015)
  • Author(s): 吉田 遼司、平木 昭光、丸瀬 靖之、永田 将士、廣末 晃之、川原 健太、松岡 祐一郎、篠原 正徳、中山 秀樹
  • Journal Title: Journal of Japanese Society of Oral Oncology Volume: 27 Issue: 4 Pages: 127-134
  • DOI: 10.5843/jsot.27.127
  • NAID: 130005116044
  • ISSN: 0915-5988, 1884-4995
  • Peer Reviewed / Open Access
• [Journal Article] Confidence Analysis for Multi-Class Object Recognition using the Intermediate Values from Machine Learning Algorithms (2015)
  • Author(s): 山崎俊彦, 大島 辰之輔, 相澤清晴
  • Journal Title: The Journal of The Institute of Image Information and Television Engineers Volume: 69 Issue: 8 Pages: J257-J260
  • DOI: 10.3169/itej.69.J257
  • NAID: 130005088777
  • ISSN: 1342-6907, 1881-6908
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Overexpression of nucleostemin contributes to an advanced malignant phenotype and a poor prognosis in oral squamous cell carcinoma. (2014)
  • Author(s): Yoshida R, Nakayama H, Nagata Y, Hirosue A, Tanaka T, Kawahara K, Nakagawa Y, Matsuoka Y, Sakata J, Akita H, Hiraki A, Shinohara M, and Ito T
  • Journal Title: Brit J Cancer Volume: 111 Issue: 12 Pages: 2308-2315
  • DOI: 10.1038/bjc.2014.539
  • Peer Reviewed / Open Access
• [Journal Article] Overexpression of fibronectin confers cell adhesion‑mediated drug resistance (CAM-DR) against 5-FU in oral squamous cell carcinoma cells. (2014)
  • Author(s): Nakagawa Y*, Nakayama H*, Nagata M, Yoshida R, Kawahara K, Hirosue A, Tanaka T, Yuno A, Matsuoka Y, Kojima T, Yoshitake Y, Hiraki A, and Shinohara M. (* Contributed equally)
  • Journal Title: Int J Oncol. Volume: 44 Issue: 4 Pages: 1376-84
  • DOI: 10.3892/ijo.2014.2265
  • Peer Reviewed / Open Access
• [Journal Article] A low Dicer expression is associated with resistance to 5-FU-based chemoradiotherapy and a shorter overall survival in patients with oral squamous cell carcinoma. (2014)
  • Author(s): Kawahara K*, Nakayama H*, Nagata M, Yoshida R, Hirosue A, Tanaka T, Nakagawa Y, Matsuoka Y, Kojima T, Takamune Y, Yoshitake Y, Hiraki A, and Shinohara M. (* Contributed equally)
  • Journal Title: J Oral Pathol Med. Volume: 43 Issue: 5 Pages: 350-6
  • DOI: 10.1111/jop.12140
  • Peer Reviewed / Open Access
• [Journal Article] Potential Uncertainty about Image Registration in Thoracic Image-guided Radiotherapy (2014)
  • Author(s): 甲斐祐大、甲斐直樹、藤田祐次郎、丸山雅人、中口裕二、倉岡杏希子、斉藤哲雄、村上龍次
  • Journal Title: Japanese Journal of Radiological Technology Volume: 70 Issue: 11 Pages: 1311-1317
  • DOI: 10.6009/jjrt.2014_JSRT_70.11.1311
  • NAID: 130004713506
  • ISSN: 0369-4305, 1881-4883
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 小線源治療用QAファントムの作製─使用時点検への応用─ (2014)
  • Author(s): 甲斐祐大，村上龍次，丸山雅人，中口裕二，永末 望，筧 清孝，竹永枝里子，橋田昌弘，斉藤哲雄
  • Journal Title: 日本放射線技術学会雑誌 Volume: 70 Pages: 34-40
  • NAID: 130003393470
  • Peer Reviewed
• [Journal Article] Interimager Variability in ADC Measurement of the Human Brain (2014)
  • Author(s): Tsujita N, Kai N, Fujita U, Hiai Y, Hirai T, Kitajima M, Yamashita Y, Murakami R.
  • Journal Title: Magn Reson Med Sci Volume: -
  • NAID: 130003392993
  • Peer Reviewed
• [Journal Article] Can 3T MR angiography replace DSA for the identification of arteries feeding intracranial meningiomas? (2013)
  • Author(s): Uetani H, Akter M, Hirai T, Shigematsu Y, Kitajima M, Kai Y, Yano S, Nakamura H, Makino K, Azuma M, Murakami R, Yamashita Y.
  • Journal Title: American Journal of Neuroradiology Volume: 34 Issue: 4 Pages: 765-772
  • DOI: 10.3174/ajnr.a3284
  • Peer Reviewed
• [Journal Article] Added Value of High-b-Value (b = 3000 s/mm2) Diffusion-Weighted Imaging at 3 T in Relation to Fluid-Attenuated Inversion Recovery Images for the Evaluation of Cortical Lesions in Inflammatory Brain Diseases (2013)
  • Author(s): Iwashita K, Hirai T, Kitajima M, Shigematsu Y, Uetani H, Iryo Y, Azuma M, Hayashida E, Ando Y, Murakami R, Yamashita Y.
  • Journal Title: J Comput Assist Tomogr Volume: 37 Issue: 3 Pages: 338-342
  • DOI: 10.1097/rct.0b013e318288a661
  • Peer Reviewed
• [Journal Article] Classification of cerebral lymphomas and glioblastomas featuring luminance distribution analysis (2013)
  • Author(s): Yamasaki T, Chen T, Hirai T, Murakami R.
  • Journal Title: Comput Math Methods Med Volume: 619658 Pages: 1-10
  • DOI: 10.1155/2013/619658
  • Peer Reviewed
• [Presentation] 類似シーン画像を用いた物体検出のフィルタリング (2016)
  • Author(s): 井上直人, 古田諒佑, 山崎俊彦, 相澤清晴
  • Organizer: 情報処理学会第78回全国大会
  • Place of Presentation: 慶應義塾大学 矢上キャンパス（神奈川県・横浜市）
  • Year and Date: 2016-03-10
• [Presentation] カスケード型識別器と進化計算による自動最適化CNNを用いたハイブリッド画像認識 (2016)
  • Author(s): 本間拓人, 山崎俊彦, 相澤清晴, 川崎順平, 茶谷亮裕, 進藤俊彦
  • Organizer: 電子情報通信学会, 信学技報, 画像工学研究会
  • Place of Presentation: 北海道大学（札幌市）
  • Year and Date: 2016-02-22
• [Presentation] Lymph Node Staging Based on the Neck Node Level in Patients with Hypopharyngeal Carcinoma treated with Radiation Therapy (2015)
  • Author(s): Semba A, Murakami R, Saito T, Mastuyama T, Mastuyama K, Toyofuku T, Oya N
  • Organizer: 日本放射線腫瘍学会 第28回学術大会
  • Place of Presentation: ベイシア文化ホール・前橋商工会議所会館（群馬県前橋市）
  • Year and Date: 2015-11-19
• [Presentation] IL-6 confers radioresistance via Nrf2 antioxidant pathway in oral squamous cell carcinoma cells (2015)
  • Author(s): Nakayama H, Matsuoka Y, Yoshida R, Hirosue A, Tanaka T, Nagata M, Kawahara K, Ogi H, Hiraki A, Shinohara M
  • Organizer: 第63回国際歯科研究学会日本部会総会・学術大会、福岡国際会議場
  • Place of Presentation: 福岡国際会議場（福岡県・福岡市）
  • Year and Date: 2015-10-30
• [Presentation] Pattern of Lymph Node Involvement and Prognosis in Patients with Stage III-IV Oral Cancer Treated With Concurrent Chemoradiation Therapy (2015)
  • Author(s): Murakami R, Nakayama H, Toya R, Hiraki A, Nagata M, Kawahara K, Hirai T, Yamashita Y
  • Organizer: 57th Annual Meeting of American Society for Radiation Oncology (ASTRO)
  • Place of Presentation: サンアントニオ（米国）
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Assessment of the Neck Node Levels in Patients with Hypopharyngeal Carcinoma (2015)
  • Author(s): Semba A, Murakami R, Murakami D, Toya R, Hirai T, Saito T, Matsuyama T, Toyofuku T, Oya N
  • Organizer: 57th Annual Meeting of American Society for Radiation Oncology (ASTRO)
  • Place of Presentation: サンアントニオ（米国）
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] テント上悪性星細胞腫の予後予測と予後因子の分析 (2015)
  • Author(s): 脇山怜，内山良一，中村英夫，平井俊範，村上龍次
  • Organizer: 第43回日本放射線技術学会秋季学術大会
  • Place of Presentation: 金沢市文化ホール（石川県・金沢市）
  • Year and Date: 2015-10-08
• [Presentation] A Fast Table-Based Approach of Bag-of-Features for Large-Scale Image Classification (2015)
  • Author(s): 邱盟竣, 山崎俊彦, 相澤清晴
  • Organizer: 映像情報メディア学会年次大会2015
  • Place of Presentation: 東京理科大学葛飾キャンパス（東京都・葛飾区）
  • Year and Date: 2015-08-26
• [Presentation] Nodal level involvement in patients with hypopharyngeal carcinoma (2015)
  • Author(s): Akiko Semba, Ryuji Murakami, Ryo Toya, Tetsuo Saito, Tomohiko Matsuyama, Yoshiyuki Fukugawa, Takamasa Toyofuku, Natsuo Oya
  • Organizer: 第74回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2015-04-16
• [Presentation] Geometrical Uncertainties Present in the Process of Radiation Therapy (2015)
  • Author(s): Ryuji Murakami
  • Organizer: 第74回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2015-04-16
  • Invited
• [Presentation] 多クラス物体認識のための学習を用いた確信度推定 (2015)
  • Author(s): 大島辰之輔, 山崎俊彦, 相澤清晴
  • Organizer: 電子情報通信学会マルチメディア・仮想環境基礎研究会 (MVE)
  • Place of Presentation: 成蹊大学（東京都武蔵野市）
  • Year and Date: 2015-03-03 – 2015-03-04
• [Presentation] 画像パッチ検索を利用したBag-of-Featuresの高速化 (2015)
  • Author(s): 伊藤慧, 相澤清晴, 山崎俊彦
  • Organizer: 電子情報通信学会マルチメディア・仮想環境基礎研究会 (MVE)
  • Place of Presentation: 成蹊大学（東京都武蔵野市）
  • Year and Date: 2015-03-03 – 2015-03-04
• [Presentation] Correlation of Daily Setup with Image Registration and Body Configuration in Image-Guided Radiotherapy (2014)
  • Author(s): Naoki Kai, Yujiro Fujita, Ryuji Murakami, Yuji Nakaguchi, Masato Maruyama, Tetsuo Saito
  • Organizer: RSNA 2014 - Radiological Society of North America
  • Place of Presentation: シカゴ（米国）
  • Year and Date: 2014-11-30 – 2014-12-05
• [Presentation] One-vs-All SVMによる多クラス画像認識における認識結果に対する「確信度」解析 (2014)
  • Author(s): 山崎俊彦
  • Organizer: 2014年度映像メディア処理シンポジウム (IMPS 2014)
  • Place of Presentation: ラフォーレ修善寺（静岡県伊豆市）
  • Year and Date: 2014-11-12 – 2014-11-14
• [Presentation] Multi-stage object classification featuring confidence analysis of classifier and inclined local naive Bayes nearest neighbor (2014)
  • Author(s): T. Maeda, T. Yamasaki, K. Aizawa
  • Organizer: 2014 IEEE International Conference on Image Processing (ICIP)
  • Place of Presentation: パリ（フランス）
  • Year and Date: 2014-10-27 – 2014-10-30
• [Presentation] 非等方拡散フィルタと解剖学的位置情報を用いたMR画像における顎下腺の抽出法 (2014)
  • Author(s): 緒方裕香，村川彩希，内山良一，村上龍次
  • Organizer: 第42回日本放射線技術学会秋季学術大会
  • Place of Presentation: 札幌コンベンションセンター（札幌）
  • Year and Date: 2014-10-09 – 2014-10-11
• [Presentation] SVM is not always confident: telling whether the output from SVM is true or false by analyzing its confidence values (2014)
  • Author(s): T. Yamasaki, T. Maeda, K. Aizawa
  • Organizer: 2014 IEEE 16th International Workshop on Multimedia Signal Processing (MMSP)
  • Place of Presentation: ジャカルタ（インドネシア）
  • Year and Date: 2014-09-22 – 2014-09-24
• [Presentation] Prognostic Impact of the Nodal Level Involvement in Advanced Oral Cancer Treated With Preoperative Concurrent Chemoradiation Therapy (2014)
  • Author(s): Ryuji Murakami, Naoki Kai, Yujiro Fujita, Ryo Toya, Toshinori Hirai, Hideki Nakayama, Yasuyuki Yamashita, Masanori Shinohara
  • Organizer: ASTRO's 56th Annual Meeting - American Society for Radiation Oncology (ASTRO)
  • Place of Presentation: サンフランシスコ（米国）
  • Year and Date: 2014-09-14 – 2014-09-17
• [Presentation] Potential Uncertainty as to 3D Image Registration in Thoracic Image-Guided Radiotherapy (2014)
  • Author(s): Yujiro Fujita, Naoki Kai, Yuji Nakaguchi, Masato Maruyama, Kiyotaka Kakei, Yudai Kai, Tetsuo Saito, Ryuji Murakami
  • Organizer: ASTRO's 56th Annual Meeting - American Society for Radiation Oncology (ASTRO)
  • Place of Presentation: サンフランシスコ（米国）
  • Year and Date: 2014-09-14 – 2014-09-17
• [Presentation] Radiotherapy for Nasopharyngeal Carcinoma: Predictability of Treatment Outcomes at Interim Re-assessment (2014)
  • Author(s): Ryo Toya, Ryuji Murakami, Daizo Murakami, Yuji Baba, Ryuichi Nishimura, Tomohiko Matsuyama, Tetsuo Saito, Akiko Semba, Eiji Yumoto, Yasuyuki Yamahita, Natsuo Oya
  • Organizer: ASTRO's 56th Annual Meeting - American Society for Radiation Oncology (ASTRO)
  • Place of Presentation: サンフランシスコ（米国）
  • Year and Date: 2014-09-14 – 2014-09-17
• [Presentation] Assessment of nodal level involvement in patients with oropharyngeal carcinoma treated with definitive radiation therapy (2014)
  • Author(s): Akiko Semba, Ryuji Muramami, Ryo Toya, Tetsuo Saito, Tomohiko Matsuyma, Yoshiyuki Hukugawa, Toyohuku Takamasa, Daizo Murakami, Natsuo Oya
  • Organizer: 第73回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2014-04-10 – 2014-04-13
• [Presentation] Concurrent chemoradiotherapy with S-1 in patients with advanced oral cavity squamous cell carcinoma (2014)
  • Author(s): Ryo Toya, Ryuji Murakami, Tetsuo Saito, Hideki Nakayama, Masashi Nagata, Akimitsu Hiraki, Yoshiyuki Fukugawa, Akiko Semba, Masanori Shinohara, Natsuo Oya
  • Organizer: 第73回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2014-04-10 – 2014-04-13
• [Presentation] Assessment of Cervical Nodal-Level Involvement in Patients with Advanced Oral Cancer Treated with Preoperative Concurrent Chemoradiation Therapy (2013)
  • Author(s): Murakami R, Kai N, Fujita Y, Nakayama H, Nagata M, Saito T, Toya R, Hirai T.
  • Organizer: 第55回米国放射線腫瘍学会（ASTRO 2013）
  • Place of Presentation: アトランタ（米国）
• [Presentation] Interobserver and Intraobserver Variability in Image Registration for Image Guided Radiation Therapy (2013)
  • Author(s): Murakami R, Fujita Y, Kai N, Nakaguchi Y, Maruyama M, Kakei K, Saito T, Toya R.
  • Organizer: 第55回米国放射線腫瘍学会（ASTRO 2013）
  • Place of Presentation: アトランタ（米国）
• [Book] 『図解 診療放射線技術実践ガイド 第３版』 第３章 ６．疾患と照射術式 脳・脊髄腫瘍 (2014)
  • Author(s): 村上龍次
  • Total Pages: 1084
  • Publisher: 文光堂
• [Book] 『画像診断ガイドライン2013年版』 ②頭頸部 (2013)
  • Author(s): 内山雄介，大原有紗，北島美香，小島和行，村上龍次
  • Total Pages: 476
  • Publisher: 金原出版
• [Book] 『小線源治療部会ガイドラインに基づく密封小線源治療 診療・物理QAマニュアル』 ９章 管腔臓器 C胆管 (2013)
  • Author(s): 村上龍次
  • Total Pages: 278
  • Publisher: 金原出版