Targeted delivery of anti-cancer-drug using nanocapsules, directed by radiotherapy.
Project/Area Number |
25461924
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Iwate Medical University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | ドラッグデリバリー / 放射線治療 / 癌化学療法 / PIXE / micro PIXE camera / 放射線 / 薬剤標的療法 / マイクロカプセル / パーティクルイメージング / マイクロプローブイメージング / Radiaton / Drug Delivery System / Protamin / Hyaluronic acid / Alginate / 癌治療 / 免疫療法 / ナノパーティクル / PIXE / DDS / Nanocapsule / Radiotherapy |
Outline of Final Research Achievements |
We aimed to image malignant tumors by 2 radiotherapy sessions In the first session, we injected CT-detectable microcapsules with P-selectin to observe malignant tumors by VEGFR-1/2 and αvβ3antibody-antigen complex accumulation. In the second session, we performed chemo-radiotherapy using microcapsules which have a high affinity for P-selectin and PSGL-1. In the first session, anti-VEGFR-1/2 and anti-αvβ3microcapsules accumulated in the malignant tumor, which could be detected by CT. These microcapsules released P-selectin and PSGL-1 in response to the first irradiation. Subsequently, microcapsules for tumor treatment were injected. Those microcapsules accumulated around the tumor through P-selectin-antigen-antibody reaction. In the second session, microcapsules released carboplatin. The released carboplatin attacked synertistically with radiation, which resulted in increased antitumor effect. And localization of carboplatin by capsules reduced adverse effect.
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Report
(5 results)
Research Products
(22 results)
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[Presentation] Nanoparticle imaging, and treatment of micrometastasis, using targeted anti-CD47 siRNA nanoparticle, via radiotherapy2015
Author(s)
Satoshi Harada , Shigeru Ehara a, Keizo Ishii , Takahiro Sato , Masashi Koka , Tomihiro Kamiya, Koichiro Sera, Shyoko Goto.
Organizer
101th Annual Meeting of Radiological Society of North America.
Place of Presentation
Chicago, IL USA
Year and Date
2015-11-29
Related Report
Int'l Joint Research
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[Presentation] Tumor Imaging, Imaging of primary tumor and metastases and their treatment through targeted immunogenic cell death and abscopal effect, using encapsulated nanoparticles directed by radiotherapy. siRna Nanoparticles and Radiotherapy.2015
Author(s)
Satoshi Harada , Shigeru Ehara a, Keizo Ishii , Takahiro Sato , Masashi Koka , Tomihiro Kamiya, Koichiro Sera, Shyoko Goto.
Organizer
Annual meeting of American Society of Therapeutic Radiation Oncology
Place of Presentation
San, Antonio TX, USA
Year and Date
2015-10-18
Related Report
Int'l Joint Research
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[Presentation] Nanoparticle imaging and treatment of micrometastasis, using targeted anti-CD47 siRNA nanoparticle, via radiotherapy.2014
Author(s)
Satoshi Harada , Shigeru Ehara a, Keizo Ishii , Takahiro Sato , Masashi Koka , Tomihiro Kamiya, Koichiro Sera, Shyoko Goto
Organizer
100th Annual Meeting of Radiological Society of North America
Place of Presentation
Mc Cormic place, Chicago, IL USA
Year and Date
2014-11-30 – 2014-12-05
Related Report
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[Presentation] Tumor Imaging, Antitumor Action, and Inhibition of Metastasis Using Targeted Anti-CD472014
Author(s)
Satoshi Harada , Shigeru Ehara a, Keizo Ishii , Takahiro Sato , Masashi Koka , Tomihiro Kamiya, Koichiro Sera, Shyoko Goto
Organizer
56th Annual meeting of American Society of Therapeutic Radiation Oncology
Place of Presentation
Moscone Convention Center, San Francisco, CA, USA
Year and Date
2014-09-14 – 2014-09-17
Related Report
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