Interaction of heavy-ion radiotherapy combined with chemotherapy for locally advanced non-small-cell lung cancer

• Project/Area Number: 25461925
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Saitama Medical University
• Principal Investigator: TAKAHASHI TAKEO 埼玉医科大学, 医学部, 教授 (70241883)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 重粒子線 / 炭素線 / 抗癌剤 / 増感効果 / 非小細胞肺癌 / アポトーシス / セネッセンス / 肺癌

Outline of Final Research Achievements

It is known that relative biological effectiveness (RBE) of high-LET carbon-ion irradiation is higher than that of low-LET radiation such as X-ray.
We investigate the difference of radiosensitivities (clonogenic survival assay and cell proliferation) between carbon-ion beam irradiation combined with chemotherapy agents and X-ray irradiation combined with chemotherapy for non-small-cell lung cancer cell line, H460, in vitro. Carboplatin (CBDCA) or paclitaxel (PTX) was concomitantly used with carbon-ion irradiation. CBDCA and PTX showed a synergistic effect on cell-killing over carbon-ion beam for H460 cells in vitro. Carbon-ion beam combined with CBDCA or PTX induced apoptosis and senescence, and increased the expression of p21, p53, and Bax.

Research Products

• [Journal Article] Nationwide multi-institutional retrospective analysis of high-dose-rate brachytherapy combined with external beam radiotherapy for localized prostate cancer: An Asian Prostate HDR-BT Consortium. (2017)
  • Author(s): Ishiyama H, Kamitani N, Kawamura H, Kato K, Aoki M, Kariya S, Matsumura T, Kaidu M, Yoshida K, Hashimoto Y, Noda Y, H.C.Lim, Kawase T, Takahashi T, Inada K, Kumano M, Yoshikawa N, Yoshioka Y, Nakamura K, Hiratsuka J, Itami J, Hayakawa K.
  • Journal Title: Brachytherapy Volume: 印刷中
  • Peer Reviewed / Open Access
• [Journal Article] The Impact of Variation in Bladder Volume on the Doses of Target and Organ-at-Risk in Intensity-Modulated Radiation Therapy for Localized Prostate Cancer. (2016)
  • Author(s): Hatanaka S, Kawada Y, Washizu K, Utsumi N, Yamano T, Nishimura K, Watanabe T, Hosaka K, Todoroki K, Nakajima G , Shimbo M, Takahashi T.
  • Journal Title: J Cancer Ther Volume: 7 Pages: 741-751
  • Peer Reviewed / Open Access
• [Journal Article] A Case of Pulmonary Artery Intimal Sarcoma Presenting as a Lung Tumor. (2016)
  • Author(s): Nishimura K, Takahashi T, Shimizu Y, Yamano T, Hatanaka S, Shimbo M, Washizu K, Utsumi N, Gika M, Sakurai H, Nakayama M, Honda N.
  • Journal Title: J Radiol Radiat Ther Volume: 4 Pages: 1064-1064
  • Peer Reviewed / Open Access
• [Journal Article] Output-limiting symptoms induced by radiofrequency hyperthermia. Are they predictable? (2016)
  • Author(s): Shoji H, Motegi M, Osawa K, Okonogi N, Okazaki A, Andou Y, Asao T, Kuwano H, Takahashi T, Ogoshi K
  • Journal Title: Int J Hyperthermia Volume: 32 Pages: 199-203
  • Peer Reviewed / Open Access
• [Journal Article] Output-limiting symptoms induced by radiofrequency hyperthermia. Are they predictable?. (2016)
  • Author(s): Shoji H, Motegi M, Osawa K, Okonogi N, Okazaki A, Andou Y, Asao T, Kuwano H, Takahashi T, Ogoshi K
  • Journal Title: nt J Hyperthermia Volume: 32 Pages: 199-203
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Radiosenseitizing effect of carboplatin and paclitaxel to carbon-ion beam irradiation in the non-small-cell lung cancer cell line H460. (2015)
  • Author(s): Kubo N, Noda SE, Takahashi A, Yoshida Y, Oike T, Murata K, Musha A, Suzuki Y, Ohno T, Takahashi T, Nakano T
  • Journal Title: J Radiat Res Volume: ５６ Pages: 229-238
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of therapeutic gain for fractionated carbon-ion radiotherapy using the tumor growth delay and crypt survival assays. (2015)
  • Author(s): Yoshida Y, Ando K, Ando K, Murata K, Yoshimoto Y, Musha A, Kubo N, Kawamura H, Koike S, Uzawa a, Takahashi T, Ohno T, Nakano T
  • Journal Title: Radiother Oncol Volume: 117 Pages: 351-357
  • Peer Reviewed / Open Access
• [Journal Article] A novel strategy of radiofrequency hyperthermia (neotherapy) in combination with preoperative chemoradiotherapy for the treatment of advanced rectal cancer. A pilot study. (2015)
  • Author(s): .Shoji H, Motegi M, Osawa K, Okonogi N, Okazaki A, Andou Y, Asao T, Kuwano H, Takahashi T, Ogoshi K
  • Journal Title: Cancer Med Volume: ４ Pages: 834-843
  • Peer Reviewed / Open Access
• [Journal Article] Radiosensitizing effect of carboplatin and paclitaxel to carbon-ion beam irradiation in the non-small-cell lung cancer cell line H460. (2015)
  • Author(s): Kubo N, Noda SE, Takahashi A, Yoshida Y, Oike T, Murata K, Musha A, Suzuki Y, Ohno T, Takahashi T, Nakano T.
  • Journal Title: J Radiat Res. Volume: 56 Issue: 2 Pages: 229-238
  • DOI: 10.1093/jrr/rru085
  • Peer Reviewed
• [Journal Article] Current Advances in Radiotherapy for Non-Small-Cell Lung Cancer: from Conventional Radiotherapy to Carbon-Ion Radiotherapy. (2014)
  • Author(s): Takahashi T.
  • Journal Title: Journal of Clinical Oncology and Research Volume: ２ Pages: 1020-1020
  • Peer Reviewed / Open Access
• [Journal Article] Carbon-ion radiotherapy for non-squamous cell head and neck malignancies. (2014)
  • Author(s): Takahashi T, Saitoh J, Shirai K, Nishimura K, Ohno T, Nakano T.
  • Journal Title: Journal of Radiology & Radiation Therapy Volume: ２ Pages: 1046-1046
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Long-term pathological and immunohistochemical features in the liver after intraoperative whole-liver irradiation in rats. (2014)
  • Author(s): Imaeda M, Ishikawa H, Yoshida Y, Takahashi T, Ohkubo Y, Musha A, Komachi M, Nakazato Y, Nakano T.
  • Journal Title: J Radiat Res. Volume: 55 Issue: 4 Pages: 665-673
  • DOI: 10.1093/jrr/rru005
  • Peer Reviewed / Open Access
• [Journal Article] Increase in cell motility by carbon ion irradiation via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632 in lungadenocarcinoma A549 cells. (2014)
  • Author(s): Kazutoshi Murata, Shin-ei Noda, Takahiro Oike, Akihisa Takahashi, Yukari Yoshida, Yoshiyuki Suzuki, Tatsuya Ohno, Tomoo Funayama, Yasuhiko Kobayashi, Takeo Takahashi, Takashi Nakano
  • Journal Title: J Radiat Res. Volume: 55 Issue: 4 Pages: 658-664
  • DOI: 10.1093/jrr/rru002
  • Peer Reviewed / Open Access
• [Journal Article] Increase in cell motility by carbon ion irradaition via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632 in LUNG adenocarcinoma A549 cells. (2014)
  • Author(s): Murata K, Noda SE, Oike T, Takahashi A, Yoshida Y, Suzuki Y, Ohno T, Funayama T, Kobayashi Y, Takahashi T, Nakano T
  • Journal Title: J Radiat Res Volume: in press
  • Peer Reviewed
• [Journal Article] Usefulness of double dose contrast-enhanced magnetic resonance imaging for clear delineation of gross tumor volume in stereotactic radiotherapy treatment planning of metastatic brain tumors: a dose comparison study. (2013)
  • Author(s): Subedi KS, Takahashi T, Yamano T, Saitoh J, Nishimura K, Suzuki Y, Ohno T, Nakano T
  • Journal Title: J Radiat Res Volume: 54 Pages: 135-139
  • Peer Reviewed
• [Journal Article] Role and Progression of Radiotherapy for Locally Advanced Esophageal Cancer. (2013)
  • Author(s): Takahashi T, Nishimura K, Yamano T.
  • Journal Title: Journal of Gastrointestinal & Digestive System Volume: S1 Issue: S1 Pages: 1-4
  • DOI: 10.4172/2161-069x.s1-005
  • Peer Reviewed
• [Journal Article] Role of hyperthermia in the treatment of gastrointestinal cancers. (2013)
  • Author(s): Takahashi T, Saitoh J, Okonogi N, Okazaki A
  • Journal Title: Thermal Medicine Volume: 29 Pages: 25-36
  • NAID: 10031161859
  • Peer Reviewed
• [Journal Article] Prognosis was not deteriorated by multiple pathway cancers in esophageal cancer patients treated by radiotherapy. (2013)
  • Author(s): Shirai K, Tamaki Y, Kitamoto Y, Murata K, Satoh Y, Higuchi K, Ishikawa H, Nonak T, Takahashi T, Nakano T
  • Journal Title: J Radiat Res Volume: 54 Pages: 706-711
  • Peer Reviewed
• [Presentation] 放射線治療の有害事象に対する治療とケア (2016)
  • Author(s): 髙橋健夫、西村敬一郎、山野貴史、鷲巣佳奈
  • Organizer: 第54回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-10-20
  • Invited
• [Presentation] 再発・転移性腫瘍に対する緩和的放射線治療がQOLならびに精神心理に及ぼす影響 (2016)
  • Author(s): 髙橋健夫、西村敬一郎、山野貴史、鷲巣佳奈、内海暢子、本戸幹人、村田修、畑中星吾、新保宗史
  • Organizer: 第54回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-10-20
  • Invited
• [Presentation] 直腸癌に対する集学的治療としてのハイパーサーミア． (2016)
  • Author(s): 東海林久紀、神保一樹、菅原幸志、須田悟志、茂木政彦、村田裕人、生越喬二、髙橋健夫、浅尾高行、桑野博行．
  • Organizer: 日本ハイパーサーミア学会第33回大会
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2016-09-02
  • Invited
• [Presentation] Studies on radiation protection and regulations in medicine granted by Ministry of Health, Labour and Welfare of Japan (2016)
  • Author(s): Hosono M, Yamaguchi I, Takahashi T, Akahane M, Ikebuchi H, Yanagida S, Nakamura Y, Kitaoka A, Sakaguchi K, Hanaoka K
  • Organizer: The 75th Annual Meeting of the Japanese Radiological Society
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-04-14
• [Presentation] 再発転移に対する放射線治療によるＱＯＬならびに精神反応に及ぼす影響についての検討 (2016)
  • Author(s): 髙橋健夫、西村敬一郎、山野貴史、上野周一、新保宗史、畑中星吾、本戸幹人、村田修、長田久人、本田憲業
  • Organizer: 第75回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-04-14
• [Presentation] Role of preoperative chemoradiotherapy for lower rectal cancer. (2015)
  • Author(s): Takahashi T
  • Organizer: 28th Annual Meeting of JASTRO
  • Place of Presentation: ベイシア文化ホール（群馬県前橋市）
  • Year and Date: 2015-11-19
  • Invited
• [Presentation] Initial treatment experience of neoadjuvant chemoradiotherapy for locally advanced lower rectal cancer. (2015)
  • Author(s): Nishimura K, Takahashi T, Yamano T, Ueno S, Hondo M, Murata O, Hatanaka S, Shimbo M, Ishibasi K, Osada H, Isida H
  • Organizer: 28th Annual Meeting of JASTRO
  • Place of Presentation: ベイシア文化ホール（群馬県前橋市）
  • Year and Date: 2015-11-19
• [Presentation] Radiotherapy outcome of T4 esophageal cancer in our institute. (2015)
  • Author(s): Yamano T, Takahashi T, Nishimura K, Ueno S, Hondo M, Murata O, Hatanaka S, Shimbo M, Kumagai Y, Osada H, Ishida H
  • Organizer: 28th Annual Meeting of JASTRO
  • Place of Presentation: ベイシア文化ホール（群馬県前橋市）
  • Year and Date: 2015-11-19
• [Presentation] Treatment outcomes of hypofractionated stereotactic radiotherapy for inoperable cerebral arteriovenous malformations. (2015)
  • Author(s): Yamano T, Takahashi T, Nishimura K, Ueno S, Shimbo M, Hondo M, Hatanaka S, Murata O, Okada T, Honda N
  • Organizer: 12th International Stereotactic Radiosurgery Society Congress.
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-06-07
  • Int'l Joint Research
• [Presentation] Moderately-hypofractionated Stereotactic Body Radiotherapy for Lung Cancer. (2015)
  • Author(s): Nishimura K, Takahashi T, Yamano T, Ueno S, Murata O, Hondo M, Ohno H, Watanabe W, Osada H, Honda N
  • Organizer: 15th International congress of Radiation Research
  • Place of Presentation: 京都国際会議場（京都府京都市）
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Treatment outcomes of hypofractionated stereotactic radiotherapy for inoperable cerebral arteriovenous malformations. (2014)
  • Author(s): Yamano T, Nishimura K, Ueno S, Shinbo M, Murata O, Ohno H, Shimizu Y, Osada H, Honda N, Takahashi T.
  • Organizer: The 15th Asian Oceanian Congress of Radiology.
  • Place of Presentation: Kobe Convention Center(兵庫県神戸市)
  • Year and Date: 2014-09-24 – 2014-09-28
• [Presentation] Preliminary result of hyperthermochemoradiotherapy using IMRT and capecitabine for advanced low-rectal cancer. (2014)
  • Author(s): Takakusagi Y, Okonogi N, Okazaki A, Motegi M, Onishi M, Ogoshi K, Takahashi T, Asao T, Kuwano H, Nakano T.
  • Organizer: The 6th Asian Congress of Hyperthermic Oncology The 31st Japanese Congress of Thermal Medicine.
  • Place of Presentation: AOSSA(福井県福井市)
  • Year and Date: 2014-09-05 – 2014-09-06
• [Presentation] 肺腺癌細胞における炭素線誘発遊走能増加と遊走能に対するROCK阻害剤の抑制作用ついて． (2014)
  • Author(s): 村田和俊、野田真永、尾池貴洋、高橋昭久、吉田由香里、鈴木義行、大野達也、舟山知夫、小林泰彦、髙橋健夫、中野隆史．
  • Organizer: 第52回日本癌治療学会学術集会．
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-08-28 – 2014-08-30
• [Presentation] Carbon-ion Radiotherapy for Non-squamous Head and Neck Cancer. (2014)
  • Author(s): Takahashi T.
  • Organizer: BIT’s 7th Annual World Cancer Congress 2014.
  • Place of Presentation: Nanjing, China
  • Year and Date: 2014-05-16 – 2014-05-18
• [Presentation] Analysis of calculation data at MU Value of the radiation therapy. (2014)
  • Author(s): Shimbo M, Nakajima G, Shimada T, Arai T, Sugimura K, Todoroki K, Hosaka K, Ootomo T, Yamakawa M, Watanabe T, Nishimura K, Yamano T, Ueno S, Takahashi T.
  • Organizer: The 107th Scientific Meeting of the Japan Society of Medical Physics.
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-04-10 – 2014-04-13
• [Presentation] 当施設における頭蓋内ＡＶＭにたいする寡聞勝定位放射線治療成績 (2014)
  • Author(s): 山野貴史、髙橋健夫、西村敬一郎、上野周一、本戸幹人、新保宗史、村田修、木谷哲、長田久人、本田憲業
  • Organizer: 第27回日本高精度放射線外部照射研究会
  • Place of Presentation: 東京
• [Presentation] Usefulness of a Double Dose Contrast Enhanced Magnetic Resonance Imaging for a Deliniation of Gross Tumor Volume in Stereotactic Radiotherapy for Metastatic Brain Tumors. (2013)
  • Author(s): Takahashi T, Subedi KS, Yamano T, Nishimura K, Saitoh J, Ueno S, Murata O, Osada H, Nakano T, Honda N
  • Organizer: The 6th World Cancer Congress
  • Place of Presentation: Xian(China)
  • Invited
• [Presentation] 骨転移に対する放射線治療 (2013)
  • Author(s): 髙橋健夫、西村敬一郎、儀賀理暁
  • Organizer: 第11回日本臨床腫瘍学会学術集会
  • Place of Presentation: 仙台
  • Invited
• [Presentation] 寡分割定位放射線治療が奏効した鞍上部海綿状血管腫の一例 (2013)
  • Author(s): 山野貴史、髙橋健夫、新保宗史、西村敬一郎、上野周一、本戸幹人、村田修、渡部渉、長田久人、木谷哲、本田憲業
  • Organizer: 第26回日本放射線腫瘍学会学術集会
  • Place of Presentation: 青森
• [Presentation] 温熱化学放射線治療でCRが得られた直腸癌症例の検討 (2013)
  • Author(s): 東海林久紀、矢野間透、茂木政彦、大澤清孝、菅原幸志、神保一樹、須田悟志、生越喬二、髙橋健夫、浅尾高行、桑野博行
  • Organizer: 日本ハイパーサーミア学会第30回大会
  • Place of Presentation: 横浜
• [Book] ブラッシュアップ多発性骨髄腫 (2015)
  • Author(s): 髙橋健夫
  • Total Pages: 244
  • Publisher: 中外医学社
• [Book] カラーテキスト血液病学 (2013)
  • Author(s): 髙橋健夫（木崎昌弘 編）
  • Total Pages: 688
  • Publisher: 中外医学社