High precision radiation therapy based on intra-tumoral hypoxic imaging

• Project/Area Number: 25461932
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kinki University
• Principal Investigator: NISHIMURA Yasumasa 近畿大学, 医学部, 教授 (00218207)
• Co-Investigator(Kenkyū-buntansha): TACHIBANA Izumi 近畿大学, 医学部, 講師 (00510984) ; ISHIKAWA Kazuki 近畿大学, 医学部, 助教 (10511016)
• Co-Investigator(Renkei-kenkyūsha): HOSONO Makoto 近畿大学, 医学部附属病院, 教授 (00281303)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 放射線療法 / 低酸素領域 / ミソニダゾール / 再酸素化 / 効果予測 / PET/CT / 強度変調放射線治療

Outline of Final Research Achievements

18F-fluoromisonizazole (F-MISO) PET/CT is a non-invasive method of depicting tumor hypoxia. A prospective clinical trial of F-MISO PET/CT for patients scheduled for radiotherapy (RT) was conducted. F-MISO above a value of 1.60 SUV was regarded as indicating a hypoxic area based on our previous study. Of the 22 tumors examinied, 18 tumors had hypoxic area before RT. For 17 patients, F-MISO PET/CT was performed twice before and during fractionated RT. Except for one nasopharyngeal cancer, 16 of the 17 tumors showed a decrease in hypoxic indicators, indicating reoxygenation. Local control rate of patients with SUVmax <2.0 was significantly better than that of patients with SUVmax =>2.0 (p=0.03). Also, overall survival rate of patients with SUVmax <2.0 was significantly better than that of patients with SUVmax =>2.0 (p=0.004). In conclusion, most human tumors contain hypoxic areas before treatment. F-MISO SUVmax =>2.0 before treatment may predict poor prognosis by RT.

Research Products

• [Journal Article] Novel anisotropic margin calculation based on the cumulative frequency distribution of uncertainties in the clinical target volume. (2015)
  • Author(s): Kawamorita R, Monzen H, Okada W, Nakahara R, Kishimoto S, Ishii K, Nakajima T, Nishimura Y.
  • Journal Title: OMICS J Radiol Volume: 4 Issue: 04 Pages: 202-202
  • DOI: 10.4172/2167-7964.1000202
  • Peer Reviewed / Open Access
• [Journal Article] Tumor hypoxia detected by 18F-misonidazole (F-MISO) PET/CT as a prediction of initial tumor response of radiation therapy (RT). (2015)
  • Author(s): Tachibana I, Hosonno M, Inada M, Fukuda K, Tatebe H, Ishikawa K, Yokokawa M, Nakamatsu K, Matsuura T, Kanamori S, Nishimura Y.
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 93 (3S)
  • Peer Reviewed
• [Journal Article] Definitive radiotherapy for head and neck squamous cell carcinoma: update and perspectives on the basis of EBM (2015)
  • Author(s): Takeshi Kodaira; Yasumasa Nishimura; Yoshikazu Kagami; Yoshinori Ito; Naoto Shikama; Satoshi Ishikura; Masahiro Hiraoka
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 45 Issue: 3 Pages: 235-243
  • DOI: 10.1093/jjco/hyu209
  • Peer Reviewed
• [Journal Article] Clinical results of definitive-dose (50 Gy/25 fractions) preoperative chemo-radiotherapy for unresectable esophageal cancer. (2014)
  • Author(s): Ishikawa K, Nakamatsu K, Shiraishi O, Yasuda T, Nishimura Y.
  • Journal Title: Int J Clin Oncol Volume: e-Pub Issue: 3 Pages: 531-537
  • DOI: 10.1007/s10147-014-0736-9
  • Peer Reviewed
• [Journal Article] A Prospective Clinical Trial of Tumor Hypoxia Imaging with 18F-fluoromisonidazole Positron Emission Tomography and Computed Tomography (F-MISO PET/CT) before and during Radiation Therapy (2013)
  • Author(s): Tachibana I, Nishimura Y, Shibata T, Kanamori S, Nakamatsu K, Koike R, Nishikawa T, Ishikawa K, Tamura M, Hosono M
  • Journal Title: J Radiation Research Volume: 54 Issue: 6 Pages: 1078-84
  • DOI: 10.1093/jrr/rrt033
  • Peer Reviewed
• [Journal Article] Dosimetric properties and clinical application of an a-Si EPID for dynamic IMRT quality assurance. (2013)
  • Author(s): Matsumoto K
  • Journal Title: Radiol Phys Technol Volume: 6 Issue: 1 Pages: 210-218
  • DOI: 10.1007/s12194-012-0190-1
  • Peer Reviewed
• [Journal Article] Volume and dosimetric changes and initial clinical experience of a two-step adaptive intensity modulated radiation therapy (IMRT) scheme for head and neck cancer. (2013)
  • Author(s): Nishi T
  • Journal Title: Radiother Oncol Volume: 106 Issue: 1 Pages: 85-89
  • DOI: 10.1016/j.radonc.2012.11.005
  • Peer Reviewed
• [Journal Article] Human papillomavirus DNA and p16 expression in Japanese patients with oropharyngeal squamous cell carcinoma. (2013)
  • Author(s): Kawakami, H., Okamoto, I., Terao, K., Sakai, K., Suzuki, M., Ueda, S., Tanaka, K., Kuwata, K., Morita, Y., Ono, K., Nishio, K., Nishimura, Y., Doi, K., Nakagawa, K.
  • Journal Title: Cancer Med. Volume: 2(6) Issue: 6 Pages: 933-41
  • DOI: 10.1002/cam4.151
  • Peer Reviewed
• [Presentation] Tumor hypoxia detected by 18F-misonidazole (F-MISO) PET/CT as a prediction of initial tumor response of radiation therapy (RT). (2015)
  • Author(s): Tachibana I, Hosonno M, Inada M, Fukuda K, Tatebe H, Ishikawa K, Yokokawa M, Nakamatsu K, Matsuura T, Kanamori S, Nishimura Y.
  • Organizer: the 57th Annual Meeting of the American Society for Radiation Oncology
  • Place of Presentation: HB Gonzalez Convention Center, San Antonio, USA
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] 頭頸部腫瘍に対するIMRTの現状と展望 (2015)
  • Author(s): 西村恭昌
  • Organizer: 第20回北奥羽放射線治療懇話会
  • Place of Presentation: 八幡平ロイヤルホテル、八幡平市
  • Year and Date: 2015-09-05
  • Invited
• [Presentation] PET/CT画像を用いた治療計画について (2015)
  • Author(s): 立花和泉
  • Organizer: 日本核医学会PET核医学分科会主催 PETサマーセミナーin 東京ベイ
  • Place of Presentation: 東京ベイ舞浜ホテルクラブリゾート、浦安市
  • Year and Date: 2015-09-05
  • Invited
• [Presentation] Tumor hypoxia imaging with 18F-misonidazole (F-MISO) positron emission tomography (PET) during radiation therapy (RT). (2015)
  • Author(s): Tachibana I, Hosonno M, Ishikawa K, Nakamatsu K, Yokokawa M, Matsuura T, Tatebe H, Inada M, Fukuda K, Kanamori S, Nishimura Y.
  • Organizer: the 15th International Congress of Radiation Research
  • Place of Presentation: 国立京都国際会館、京都市
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Texture analysis of intratumoral hypoxia on FMISO PET/CT in radiation therapy. (2014)
  • Author(s): Hosono M, Tachibana I, Nishimura Y, Hanaoka K, Kanamori S, Nakamatsu K, Ishikawa K.
  • Organizer: the Annual Congress of European Association of Nuclear Medicine
  • Place of Presentation: Gothenburg, Sweden
  • Year and Date: 2014-10-18 – 2014-10-22
• [Presentation] Clinical outcome of radiation therapy for esophageal cancer between 2004 and 2008: second survey. (2014)
  • Author(s): Nishimura Y, Jingu K, Itasaka S, Negoro Y, Murakami Y, Karasawa K, Kawaguchi G, Isohashi F, Kobayashi M, Itoh Y, Ariga T.
  • Organizer: the 56th Annual Meeting of the American Society for Radiation Oncology
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2014-09-14 – 2014-09-17
• [Presentation] Clinical results of definitive chemoradiation therapy for T4 esophageal cancer. (2014)
  • Author(s): Ishikawa K, Tatebe H, Matsuura T, Tachibana I, Yokokawa M, Nakamatsu K, Kanamori S, Nishimura Y.
  • Organizer: the 56th Annual Meeting of the American Society for Radiation Oncology
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2014-09-14 – 2014-09-17
• [Presentation] Statistical process control for EPID dosimetry in the quality assurance of IMRT. (2014)
  • Author(s): Matsumoto K, Okumura M, Asai Y, Shimomura K, Tamura M, Nishimura Y.
  • Organizer: the 56th Annual Meeting of the American Society for Radiation Oncology
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2014-09-14 – 2014-09-17
• [Presentation] Heterogeneity of intratumoral hypoxia on FMISO PET/CT in association with local control in radiation therapy. (2014)
  • Author(s): Hosono M, Tachibana I, Nishimura Y, Hanaoka K, Kanamori S, Nakamatsu K, Shibata T, Ishikawa K, Tamura M.
  • Organizer: the 56th Annual Meeting of the American Society for Radiation Oncology
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2014-09-14 – 2014-09-17
• [Presentation] Adaptive IMRT for head and neck cancer in Japan. (2014)
  • Author(s): Nishimura Y
  • Organizer: the 2nd Taiwan-Japan Conference on the High Precision Radiation Therapy
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2014-07-19 – 2014-07-20
  • Invited
• [Presentation] IMRT for head and neck cancer in Japan. (2013)
  • Author(s): Nishimura Y
  • Organizer: the MD Anderson Radiation Oncology Gilbert H Fletcher Society 37th Annual Scientific Meeting
  • Place of Presentation: Kyoto
  • Invited
• [Presentation] Chemoradiation therapy for locally advanced esophageal cancer; Japanese perspective. (2013)
  • Author(s): Nishimura Y
  • Organizer: the ESTRO-JASTRO Joint Symposium, 2nd ESTRO forum
  • Place of Presentation: Geneva, Switzerland
  • Invited
• [Presentation] Clinical outcomes of IMRT planned with or without PET/CT simulation for patients with pharyngeal cancer. (2013)
  • Author(s): Matsuura T, Ishikawa K, Tachibana I, Yokokawa M, Nishimura Y.
  • Organizer: the 55th Annual Meeting of the American Society for Radiation Oncology
  • Place of Presentation: Atlanta, USA
• [Presentation] F-MISO PET/CTを用いた低酸素イメージングと放射線治療 (2013)
  • Author(s): 西村恭昌、立花和泉、石川一樹
  • Organizer: 日本放射線影響学会第56回大会
  • Place of Presentation: 青森
  • Invited
• [Presentation] 放射線治療の進歩、放射線生物学
  • Author(s): 西村恭昌
  • Organizer: 平成25年度全国がんプロフェッショナル養成基盤推進プラン合同フォーラム
  • Place of Presentation: 東京
  • Invited
• [Book] Intensity Modulated Radiation Therapy; Clinical Evidence and Techniques (2015)
  • Author(s): Eds. Nishimura Y, Komaki R,
  • Total Pages: 473
  • Publisher: Springer
• [Book] Intensity-Modulated Radiation Therapy; Clinical Evidence and Techniques (2015)
  • Author(s): Yasumasa Nishimura, Ritsuko Komaki, editors
  • Total Pages: 473
  • Publisher: Springer