Research of relative biological effectiveness of the central nervous
| Project/Area Number |
25461933
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Nagasaki International University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | radiotherapy / Cerebral dysfunction / hippocampus / 重粒子線治療 / 脳腫瘍治療 / 炭素線治療 / 認知機能障害 / 放射線治療 / 認知機能 / QOL / 毛細血管密度 / 重粒子線 / 炭素線 / 脳腫瘍 / RBE |
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| Outline of Final Research Achievements |
This study investigated effects on the cognitive function and microvessel density (MVD) in the hippocampus after local brain irradiation with carbon ions using mice. The irradiation dose was set at level known to produce vascular change followed by necrosis, which appeared the late period after irradiation with 30 Gy. At 16 weeks after irradiation, the irradiated mice showed marked neuronal degeneration at the hippocampus within CA1 to CA3 layers at 16 weeks after irradiation. MVD of the vulnerable hippocampal-region decreased rapidly from 1 week after irradiation. The cerebral MVD also declined from 1 to 12 weeks and radiation vasculopathy was dose and time dependent. We found that the hippocampus within CA1 to CA3 layers sensitive to irradiation than DG astrocytes, the decrease of MVD and activation of astrocytes in the hippocampus have been implicated in neuronal cell death.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Localized radiation necrosis model in mouse brain using proton ion beams.2015
Author(s)
Kondo N, Sakurai Y, Takata T, Takai N, Nakagawa Y, Tanaka H, Watanabe T, Kume K, Toho T, Miyatake S, Suzuki M, Masunaga S, Ono K.
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Journal Title
Applied Radiation and Isotopes
Volume: 106
Pages: 242-246
DOI
Related Report
Peer Reviewed / Open Access
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