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The study of organ preservation solutions and oxygenated machine perfusion preservation with temperature controlled for porcine DCD liver graft

Research Project

Project/Area Number 25461939
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionAsahikawa Medical College

Principal Investigator

TANIGUCHI Masahiko  旭川医科大学, 医学部, 客員准教授 (30374333)

Co-Investigator(Kenkyū-buntansha) 古川 博之  旭川医科大学, 医学部, 教授 (70292026)
深井 原  北海道大学, 医学研究科, 特任助教 (60374344)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords心停止ドナー / 肝臓保存 / 灌流保存方法 / 人工赤血球含有灌流液 / 臓器灌流 / 臓器灌流保存液 / マージナルドナー / 心停止下ドナー / 肝移植 / 虚血再灌流障害 / 保存障害
Outline of Final Research Achievements

Utilization of grafts from donors after cardiac death (DCD) would greatly contribute to the expansion of the donor pool. To assess potential effect, porcine livers procured after 60 minutes of warm ischemic time were perfused and preserved. Study 1; The effects of subnormotherc preservation(SNP) with machine preservation(MP) Study 2;Evaluation of HES or PEG in UW gluconate solution of porcine liver grafts Study 3; Impact of solution containing artificial oxygen carrier hemoglobin vesicles(AOC).Results 1; According to increase the preservation temperature, more oxygen consumption was required and portal vein pressure was decreased. The changes of AST, LDH and hiarulonic acid were lowest in SNP. Potentially, SNP is expected to help the recovery of function. Results 2; Effluent enzyme of AST and LDH were lower in PEG group HES may not be effect as a MP solution. Results 3; MP solution containing with AOC is expected to use the recovery the function.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (19 results)

All 2016 2015 2014 2013

All Journal Article (9 results) (of which Peer Reviewed: 3 results) Presentation (8 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (2 results)

  • [Journal Article] Subnormothermic machine perfusion preservation with rewarming for donation after cardiac death liver grafts in pigs2016

    • Author(s)
      Furukori M,Matsuno N,Watanabe K,Hagiwara M,Shonaka T,Imai K,Meng KT,Obara M,Nishikawa Y,Furukawa H.
    • Journal Title

      Transpl Proc.

      Volume: 48(4) Pages: 1239-43

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Scanning Electron Microscopy Findings of Machine Perfused Liver Graft After Warm Ischemia Between Hypothermic and Rewarming Machine Perfusion in Pigs2016

    • Author(s)
      Meng L, Matsuno N, Watanabe K, Furukori M, Obara H, Bochimoto H, Watanabe T, Fukukawa H.
    • Journal Title

      Transplant Proc.

      Volume: 48(7) Pages: 2467-2470

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 複合的戦略による心停止ドナーからの移植臓器有効利用の研究 - 灌流型臓器保存を中心にした機能再生の試み -2015

    • Author(s)
      松野直徒、小原弘道、古郡茉利子、渡邊賢二、田崎嘉一、渡部剛、西川祐司、絵野沢伸、古川博之
    • Journal Title

      Organ Biology

      Volume: 22(2) Pages: 19-25

    • NAID

      130005142936

    • Related Report
      2015 Research-status Report
  • [Journal Article] 【最新肝癌学-基礎と臨床の最新研究動向-】 肝癌治療とインフォームドコンセント 肝癌手術におけるインフォームドコンセントの要点(特集)2015

    • Author(s)
      内田 浩一郎, 谷口 雅彦, 川原 敏靖, 今井 浩二, 小西 奈々美, 萩原 正弘, 渡邉 賢二, 宮本 正之, 鈴木 達也, 石井 大介, 松野 直徒, 古川 博之
    • Journal Title

      日本臨床外科学会雑誌 73増1 最新肝癌学767-771

      Volume: 73増1 Pages: 767-771

    • Related Report
      2015 Research-status Report
  • [Journal Article] tomography-gastro-colonography for percutaneous endoscopic gastrostomy using a helical computed tomography.2015

    • Author(s)
      Kato K, Taniguchi M, Iwasaki Y, Sasahara K, Nagase A, Onodera K, Matsuda M, Inaba Y, Kawakami T, Higuchi M, Kobashi Y, Furukawa H
    • Journal Title

      Am J Surg.

      Volume: 210(2) Issue: 2 Pages: 374-381

    • DOI

      10.1016/j.amjsurg.2014.10.029

    • Related Report
      2015 Research-status Report
  • [Journal Article] Small-for-size syndrome in living-donor liver transplantation using a left lobe graft.2014

    • Author(s)
      Taniguchi M, Shimamura T, Todo S, Furukawa H
    • Journal Title

      Surgery Today

      Volume: epub Issue: 6 Pages: 663-671

    • DOI

      10.1007/s00595-014-0945-x

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 肝移植におけるNF-kB活性の功罪2014

    • Author(s)
      谷口雅彦、深井原、鈴木達也、内田浩一郎、古川博之
    • Journal Title

      肝胆膵

      Volume: 68 Pages: 563-568

    • Related Report
      2014 Research-status Report
  • [Journal Article] 欧米・アジアの肝移植の現状2013

    • Author(s)
      内田浩一郎、谷口雅彦、今井浩二、永生高広、渡邉賢二、古川博之
    • Journal Title

      臨床消化器内科

      Volume: 36 Pages: 1217-1226

    • Related Report
      2013 Research-status Report
  • [Journal Article] 最新 肝胆膵脾手術アトラス「肝臓 脳死肝移植」2013

    • Author(s)
      今井浩二、谷口雅彦、古川博之
    • Journal Title

      手術

      Volume: 68 Pages: 775-783

    • Related Report
      2013 Research-status Report
  • [Presentation] 脳死下多臓器摘出講習「肝臓」2016

    • Author(s)
      古川博之
    • Organizer
      第52回日本移植学会
    • Place of Presentation
      東京都
    • Year and Date
      2016-09-29
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 我が国から発信する人工赤血球含有かん流液による心停止肝の灌流保存2016

    • Author(s)
      松野直徒、小原弘道、田崎嘉一、鈴木智之、西川祐司、佐竹由康、古郡茉里子、髙橋裕之、庄中達也、酒井宏水、古川博之
    • Organizer
      第34回日本肝移植研究会
    • Place of Presentation
      北海道旭川市
    • Year and Date
      2016-07-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 心停止ドナーからの肝臓灌流保存における温度条件の検討2016

    • Author(s)
      松野直徒、小原弘道、森戸規之、岡田陽子、孟玲童、西川祐司、古川博之
    • Organizer
      第34回日本肝移植研究会
    • Place of Presentation
      北海道旭川市
    • Year and Date
      2016-07-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Applicability of combined of extracorporeal support and temperature controlled machine perfusion preservation for DCD liver procurement.2015

    • Author(s)
      Hagiwara M, Mastuno N, Furukori M, Watanabe K, Shonaka T, Imai K, Matsunami M, Kanazawa H, Kasahara M Furukawa H
    • Organizer
      CAST2015
    • Place of Presentation
      シンガポール
    • Year and Date
      2015-08-23
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Electron microscopic recovery of preserved livers following warm ischemia Improvement by machine perfusion preservation. Transpl Proc.2015

    • Author(s)
      Meng LT, Matsuno N, Watanabe K, Furukori M, Obara H, Kuchimoto H, Watanabe T, Furukawa H:
    • Organizer
      CAST2015
    • Place of Presentation
      シンガポール
    • Year and Date
      2015-08-23
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Porcine cytokine profile associated with ischemia reperfusion injury in liver transplantation using donoation after cardiac death2014

    • Author(s)
      Hanada D, Uchida k, Suzuki T, Matsuno N, Taniguchi M, Furukawa H
    • Organizer
      World Transplant Congress 2014
    • Place of Presentation
      San Franscisco
    • Year and Date
      2014-07-26 – 2014-07-31
    • Related Report
      2014 Research-status Report
  • [Presentation] Porcine cytokine profiles associated with ischemia reperfusion injury in liver transplantation using donation after cardiac death.2014

    • Author(s)
      Hanada D, Uchida K, Suzuki T, Matsuno N, Tanigichi M, Furukawa H.
    • Organizer
      Asian Pacific Association for The Study of the Liver 2014
    • Place of Presentation
      Brisbane, Australia
    • Related Report
      2013 Research-status Report
  • [Presentation] Porcine cytokine profiles associated with ischemia reperfusion injury in liver transplantation using donation after cardiac death.2014

    • Author(s)
      Hanada D, Uchida K, Suzuki T, Matsuno N, Tanigichi M, Furukawa
    • Organizer
      World Transplant Congress 2014
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2013 Research-status Report
  • [Book] Chapter 11; ECD for adult liver transplantation, marginal donors2014

    • Author(s)
      Taniguchi M, Furukawa H
    • Publisher
      Springer
    • Related Report
      2014 Research-status Report
  • [Book] Chapter 11; ECD for adult liver transplantation. Marginal donors.2014

    • Author(s)
      Taniguchi M., Furukawa H.
    • Publisher
      Springer
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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