| Project/Area Number |
25461939
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
古川 博之 旭川医科大学, 医学部, 教授 (70292026)
深井 原 北海道大学, 医学研究科, 特任助教 (60374344)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 心停止ドナー / 肝臓保存 / 灌流保存方法 / 人工赤血球含有灌流液 / 臓器灌流 / 臓器灌流保存液 / マージナルドナー / 心停止下ドナー / 肝移植 / 虚血再灌流障害 / 保存障害 |
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| Outline of Final Research Achievements |
Utilization of grafts from donors after cardiac death (DCD) would greatly contribute to the expansion of the donor pool. To assess potential effect, porcine livers procured after 60 minutes of warm ischemic time were perfused and preserved. Study 1; The effects of subnormotherc preservation(SNP) with machine preservation(MP) Study 2;Evaluation of HES or PEG in UW gluconate solution of porcine liver grafts Study 3; Impact of solution containing artificial oxygen carrier hemoglobin vesicles(AOC).Results 1; According to increase the preservation temperature, more oxygen consumption was required and portal vein pressure was decreased. The changes of AST, LDH and hiarulonic acid were lowest in SNP. Potentially, SNP is expected to help the recovery of function. Results 2; Effluent enzyme of AST and LDH were lower in PEG group HES may not be effect as a MP solution. Results 3; MP solution containing with AOC is expected to use the recovery the function.
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