| Project/Area Number |
25461943
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
SUMI Shoichiro 京都大学, 再生医科学研究所, 准教授 (80252906)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIROUZU Yasumasa 京都大学, 再生医科学研究所, 講師 (20279186)
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| Research Collaborator |
YANAI Goichi 京都大学, 再生医科学研究所, 研究員
KAWAGOI Masako 京都大学, 再生医科学研究所, 研究員
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 膵島移植 / 間葉系幹細胞 / 細胞融合 / バイオ人工膵島 / マクロカプセル化 / 皮下移植 / 免疫隔離 / 皮下移植システム / 融合細胞 / ポリビニルアルコール / キトサン / 糖尿病治療 / 膵島 / 電気的細胞融合 / 皮下血管新生 / 細胞スフェロイド / 核リプログラミング |
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| Outline of Final Research Achievements |
Mesenchymal stem cell (MSC) is known for cell-protective and inflammation-regulating effects. Electro-fusion of MSCs and islet cells resulted in new cells possessing growth ability and anti-apoptotic function in addition to islet like cell function of glucose-responsive insulin release. In order to utilize various islet-like cells/tissues including these fusion cells, innovative macro-encapsulation system for immuno-isolation was developed together with neovascularization-indusing method to realize subcutaneous transplantation. These results formed the basis for clinical subcutaneous transplantation of islets or islet-like cells/tissues.
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