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Devlopment of novel immunosupression to regulate complement in intestinal transplant

Research Project

Project/Area Number 25461945
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionOsaka University

Principal Investigator

UENO Takehisa  大阪大学, 医学(系)研究科(研究院), 助教 (10456957)

Co-Investigator(Kenkyū-buntansha) MASAHATA Kazunori  大阪大学, 医学部付属病院, 医員 (40588381)
YAMAMITI Taku  大阪大学, 医学部付属病院, 医員 (30715165)
UMEDA Satoshi  大阪大学, 医学部付属病院, 医員 (60715176)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords小腸移植 / 拒絶 / 補体 / 補体制御 / ラット / 虚血再灌流 / 拒絶反応 / グラフト / C3 / C4 / 補体制御因子 / CD56 / DAF / 液性免疫
Outline of Final Research Achievements

Intestinal transplant is poor result comparing with other organ transplant. Current immunosuppression cannot regulate rejection. Especially antibody has a role for rejection so that novel immunosuppression to control them. Recently it was reported that expression of complement and complement regulatory factor have a major role for T cell related rejection. We investigated expression of complement and complement regulatory factors, then the relationship was revealed using ischemia and reperfusion rat model mimicking intestinal transplant.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (17 results)

All 2015 2014

All Journal Article (12 results) (of which Peer Reviewed: 11 results) Presentation (3 results) Book (2 results)

  • [Journal Article] 本邦の小腸移植症例について2015

    • Author(s)
      上野豪久
    • Journal Title

      外科と代謝・栄養

      Volume: 49 Pages: 27-33

    • NAID

      130005068216

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 本邦小腸移植症例登録報告2015

    • Author(s)
      上野 豪久, 田口 智章, 福澤 正洋
    • Journal Title

      移植

      Volume: 50 Pages: 191-195

    • NAID

      10030209420

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小腸移植における拒絶反応の治療とATG2015

    • Author(s)
      上野豪久
    • Journal Title

      今日の移植

      Volume: 28 Pages: 492-496

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical application of indocyanine green (ICG) fluorescent imaging of hepatoblastoma.2015

    • Author(s)
      Yamamichi T, Oue T, Yonekura T, Owari M, Nakahata K, Umeda S, Nara K, Ueno T, et. al
    • Journal Title

      J Pediatr Surg

      Volume: 50 Issue: 5 Pages: 833-836

    • DOI

      10.1016/j.jpedsurg.2015.01.014

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A comparison of the main structures of N-glycans of porcine islets with those from humans2014

    • Author(s)
      Miyagawa S, Maeda A, Kawamura T, Ueno T, Usui N, Kondo S, Matsumoto S, Okitsu T, Got o M, Nagashima H
    • Journal Title

      Glycobiology

      Volume: 24(2) Issue: 2 Pages: 125-138

    • DOI

      10.1093/glycob/cwt088

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Monocytic suppressor cells derived from human peripheral blood suppress xenogenic immune reactions.2014

    • Author(s)
      Maeda A, Kawamura T, Ueno T, et. al
    • Journal Title

      Xenotransplantation

      Volume: 21 Issue: 1 Pages: 46-56

    • DOI

      10.1111/xen.12067

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A structural analysis of N-glycans of neonatal porcine islet-like cell clusters (NPCC).2014

    • Author(s)
      Miyagawa S, Maeda A, Eguchi H, Kawamura T, Kashiyama N, Ueno T, et. al
    • Journal Title

      Transpl Immunol

      Volume: 31 Issue: 1 Pages: 48-53

    • DOI

      10.1016/j.trim.2014.05.003

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of intestinal transplantation for intestinal failure in Japan.2014

    • Author(s)
      Ueno T, Wada M, Hoshino K, Uemoto S, Taguchi T, Furukawa H, Fukuzawa M
    • Journal Title

      Transplant Proc

      Volume: 46 Issue: 6 Pages: 2122-4

    • DOI

      10.1016/j.transproceed.2014.06.037

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of pediatric live-donor liver transplantation with a left lateral segment reduction by a linear stapler after reperfusion2014

    • Author(s)
      Zenitani M, Ueno T, Nara K, Nakahata K, Uehara S, Soh H, Oue T, Kondo H, Nagano H, Usui N
    • Journal Title

      Pediatric Transplantation

      Volume: 18 Issue: 6

    • DOI

      10.1111/petr.12307

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 移植療法の現況と今後の展望2014

    • Author(s)
      上野豪久
    • Journal Title

      小腸移植 診断と治療

      Volume: 102 Pages: 1515-1515

    • Related Report
      2014 Research-status Report
  • [Journal Article] 全国調査に基づく我が国におけるIntestinal failureの現状―治療指針策定に向けて―2014

    • Author(s)
      上野豪久、 福澤正洋
    • Journal Title

      日本消化器吸収学会誌

      Volume: 36 Pages: 290-294

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] わが国の小児移植医療―現状と今後― 小腸移植2014

    • Author(s)
      上野豪久
    • Journal Title

      小児科

      Volume: 55 Pages: 1275-83

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 短腸症の小腸移植待機中に急速に肝不全の進行した1例2014

    • Author(s)
      上野豪久、松浦玲、出口幸一、奈良啓吾、大割貢、上原秀一郎、大植孝治、奥山宏臣
    • Organizer
      第44回 日本小児外科代謝研究会
    • Place of Presentation
      兵庫県立淡路夢舞台国際会議場(兵庫県淡路市)
    • Year and Date
      2014-10-31
    • Related Report
      2014 Research-status Report
  • [Presentation] 小児肝・小腸移植2014

    • Author(s)
      上野豪久
    • Organizer
      第51回 日本小児外科学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市北区)
    • Year and Date
      2014-05-10
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒルシュスプルング類縁疾患の小腸移植2014

    • Author(s)
      上野豪久、和田基、星野健、位田忍、藤山佳秀、馬場 重樹、貞森裕、福澤正洋
    • Organizer
      第51回 日本小児外科学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市北区)
    • Year and Date
      2014-05-08
    • Related Report
      2014 Research-status Report
  • [Book] ECD for small Intestinal Transplant2014

    • Author(s)
      Ueno T. et.al
    • Publisher
      Marginal Donor
    • Related Report
      2014 Research-status Report
  • [Book] 小腸移植2014

    • Author(s)
      上野豪久
    • Publisher
      移植ファクトブック
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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