Devlopment of novel immunosupression to regulate complement in intestinal transplant

• Project/Area Number: 25461945
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Osaka University
• Principal Investigator: UENO Takehisa 大阪大学, 医学(系)研究科(研究院), 助教 (10456957)
• Co-Investigator(Kenkyū-buntansha): MASAHATA Kazunori 大阪大学, 医学部付属病院, 医員 (40588381) ; YAMAMITI Taku 大阪大学, 医学部付属病院, 医員 (30715165) ; UMEDA Satoshi 大阪大学, 医学部付属病院, 医員 (60715176)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 小腸移植 / 拒絶 / 補体 / 補体制御 / ラット / 虚血再灌流 / 拒絶反応 / グラフト / C3 / C4 / 補体制御因子 / CD56 / DAF / 液性免疫

Outline of Final Research Achievements

Intestinal transplant is poor result comparing with other organ transplant. Current immunosuppression cannot regulate rejection. Especially antibody has a role for rejection so that novel immunosuppression to control them. Recently it was reported that expression of complement and complement regulatory factor have a major role for T cell related rejection. We investigated expression of complement and complement regulatory factors, then the relationship was revealed using ischemia and reperfusion rat model mimicking intestinal transplant.

Research Products

• [Journal Article] 本邦の小腸移植症例について (2015)
  • Author(s): 上野豪久
  • Journal Title: 外科と代謝・栄養 Volume: 49 Pages: 27-33
  • NAID: 130005068216
  • Peer Reviewed
• [Journal Article] 本邦小腸移植症例登録報告 (2015)
  • Author(s): 上野 豪久, 田口 智章, 福澤 正洋
  • Journal Title: 移植 Volume: 50 Pages: 191-195
  • NAID: 10030209420
  • Peer Reviewed
• [Journal Article] 小腸移植における拒絶反応の治療とATG (2015)
  • Author(s): 上野豪久
  • Journal Title: 今日の移植 Volume: 28 Pages: 492-496
  • Peer Reviewed
• [Journal Article] Clinical application of indocyanine green (ICG) fluorescent imaging of hepatoblastoma. (2015)
  • Author(s): Yamamichi T, Oue T, Yonekura T, Owari M, Nakahata K, Umeda S, Nara K, Ueno T, et. al
  • Journal Title: J Pediatr Surg Volume: 50 Issue: 5 Pages: 833-836
  • DOI: 10.1016/j.jpedsurg.2015.01.014
  • Peer Reviewed
• [Journal Article] A comparison of the main structures of N-glycans of porcine islets with those from humans (2014)
  • Author(s): Miyagawa S, Maeda A, Kawamura T, Ueno T, Usui N, Kondo S, Matsumoto S, Okitsu T, Got o M, Nagashima H
  • Journal Title: Glycobiology Volume: 24(2) Issue: 2 Pages: 125-138
  • DOI: 10.1093/glycob/cwt088
  • Peer Reviewed
• [Journal Article] Monocytic suppressor cells derived from human peripheral blood suppress xenogenic immune reactions. (2014)
  • Author(s): Maeda A, Kawamura T, Ueno T, et. al
  • Journal Title: Xenotransplantation Volume: 21 Issue: 1 Pages: 46-56
  • DOI: 10.1111/xen.12067
  • Peer Reviewed
• [Journal Article] A structural analysis of N-glycans of neonatal porcine islet-like cell clusters (NPCC). (2014)
  • Author(s): Miyagawa S, Maeda A, Eguchi H, Kawamura T, Kashiyama N, Ueno T, et. al
  • Journal Title: Transpl Immunol Volume: 31 Issue: 1 Pages: 48-53
  • DOI: 10.1016/j.trim.2014.05.003
  • Peer Reviewed
• [Journal Article] Impact of intestinal transplantation for intestinal failure in Japan. (2014)
  • Author(s): Ueno T, Wada M, Hoshino K, Uemoto S, Taguchi T, Furukawa H, Fukuzawa M
  • Journal Title: Transplant Proc Volume: 46 Issue: 6 Pages: 2122-4
  • DOI: 10.1016/j.transproceed.2014.06.037
  • Peer Reviewed
• [Journal Article] A case of pediatric live-donor liver transplantation with a left lateral segment reduction by a linear stapler after reperfusion (2014)
  • Author(s): Zenitani M, Ueno T, Nara K, Nakahata K, Uehara S, Soh H, Oue T, Kondo H, Nagano H, Usui N
  • Journal Title: Pediatric Transplantation Volume: 18 Issue: 6
  • DOI: 10.1111/petr.12307
  • Peer Reviewed
• [Journal Article] 移植療法の現況と今後の展望 (2014)
  • Author(s): 上野豪久
  • Journal Title: 小腸移植 診断と治療 Volume: 102 Pages: 1515-1515
• [Journal Article] 全国調査に基づく我が国におけるIntestinal failureの現状―治療指針策定に向けて― (2014)
  • Author(s): 上野豪久、 福澤正洋
  • Journal Title: 日本消化器吸収学会誌 Volume: 36 Pages: 290-294
  • Peer Reviewed
• [Journal Article] わが国の小児移植医療―現状と今後― 小腸移植 (2014)
  • Author(s): 上野豪久
  • Journal Title: 小児科 Volume: 55 Pages: 1275-83
  • Peer Reviewed
• [Presentation] 短腸症の小腸移植待機中に急速に肝不全の進行した1例 (2014)
  • Author(s): 上野豪久、松浦玲、出口幸一、奈良啓吾、大割貢、上原秀一郎、大植孝治、奥山宏臣
  • Organizer: 第44回 日本小児外科代謝研究会
  • Place of Presentation: 兵庫県立淡路夢舞台国際会議場（兵庫県淡路市）
  • Year and Date: 2014-10-31
• [Presentation] 小児肝・小腸移植 (2014)
  • Author(s): 上野豪久
  • Organizer: 第51回 日本小児外科学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市北区）
  • Year and Date: 2014-05-10
• [Presentation] ヒルシュスプルング類縁疾患の小腸移植 (2014)
  • Author(s): 上野豪久、和田基、星野健、位田忍、藤山佳秀、馬場 重樹、貞森裕、福澤正洋
  • Organizer: 第51回 日本小児外科学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市北区）
  • Year and Date: 2014-05-08
• [Book] ECD for small Intestinal Transplant (2014)
  • Author(s): Ueno T. et.al
  • Publisher: Marginal Donor
• [Book] 小腸移植 (2014)
  • Author(s): 上野豪久
  • Publisher: 移植ファクトブック