Devlopment of novel immunosupression to regulate complement in intestinal transplant
Project/Area Number |
25461945
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General surgery
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Research Institution | Osaka University |
Principal Investigator |
UENO Takehisa 大阪大学, 医学(系)研究科(研究院), 助教 (10456957)
|
Co-Investigator(Kenkyū-buntansha) |
MASAHATA Kazunori 大阪大学, 医学部付属病院, 医員 (40588381)
YAMAMITI Taku 大阪大学, 医学部付属病院, 医員 (30715165)
UMEDA Satoshi 大阪大学, 医学部付属病院, 医員 (60715176)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 小腸移植 / 拒絶 / 補体 / 補体制御 / ラット / 虚血再灌流 / 拒絶反応 / グラフト / C3 / C4 / 補体制御因子 / CD56 / DAF / 液性免疫 |
Outline of Final Research Achievements |
Intestinal transplant is poor result comparing with other organ transplant. Current immunosuppression cannot regulate rejection. Especially antibody has a role for rejection so that novel immunosuppression to control them. Recently it was reported that expression of complement and complement regulatory factor have a major role for T cell related rejection. We investigated expression of complement and complement regulatory factors, then the relationship was revealed using ischemia and reperfusion rat model mimicking intestinal transplant.
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Report
(4 results)
Research Products
(17 results)
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[Presentation] 小児肝・小腸移植2014
Author(s)
上野豪久
Organizer
第51回 日本小児外科学会学術集会
Place of Presentation
大阪国際会議場(大阪府大阪市北区)
Year and Date
2014-05-10
Related Report
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