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The role of Sonic hedgehog in intestinal injury via stem cell

Research Project

Project/Area Number 25461951
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionThe University of Tokushima

Principal Investigator

YOSHIKAWA Kozo  徳島大学, 大学病院, 助教 (80448331)

Co-Investigator(Kenkyū-buntansha) BANDO Yoshimi  徳島大学, 病院, 准教授 (00238239)
KURITA Nobuhiro  徳島大学, 病院, 特任教授 (30335814)
SATO Hirohiko  徳島大学, 病院, 特任助教 (80609694)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords腸管修復 / Sonic hedgehog / 幹細胞 / 腸管障害 / Shh pathway / Cancer stem cell
Outline of Final Research Achievements

This study focused on the relationship between the intestinal injury and Sonic hedgehog pathway. In intestinal injury models, Shh pathway was downregulated. HCT-116 sphere-derived cells showed significantly increased expression of stem cell markers, Shh downstream genes and epithelial-mesenchymal transition (EMT) markers compared to parental cells grown in conventional culture. The expression of stemness markers, Shh downstream genes and EMT markers were higher in cancer spheres than the parental cell line and downregulated by cyclopamine treatment in a dose-dependent manner. Shh pathway is related with cancer stem cell and may have an important role in intestinal injury.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (5 results)

  • [Journal Article] Combined liver mobilization and retraction: A novel technique to obtain the optimal surgical field during laparoscopic total gastrectomy.2016

    • Author(s)
      Yoshikawa K, Shimada M, Higashijima J, Nakao T, Nishi M, Takasu C, Kashihara H, Eto S.
    • Journal Title

      Asian J Endosc Surg.

      Volume: 印刷中 Issue: 2 Pages: 111-115

    • DOI

      10.1111/ases.12271

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Daikenchuto, a Traditional Japanese Herbal Medicine, after Total Gastrectomy for Gastric Cancer: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase II Trial.2015

    • Author(s)
      Yoshikawa K, Shimada M, Wakabayashi G, Ishida K, Kaiho T, Kitagawa Y
    • Journal Title

      J Am Coll Surg

      Volume: 221 Issue: 2 Pages: 571-578

    • DOI

      10.1016/j.jamcollsurg.2015.03.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclopamine decreased the expression of Sonic Hedgehog and its downstream genes in colon cancer stem cells.2014

    • Author(s)
      Batsaikhan BE, Yoshikawa K, Kurita N, Iwata T, Takasu C, Kashihara H, Shimada M
    • Journal Title

      Anticancer Res

      Volume: 34 Pages: 6339-6344

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characteristics of internal hernia after gastrectomy with Roux-en-Y reconstruction for gastric cancer2014

    • Author(s)
      Yoshikawa K, Shimada M, Kurita N, Sato H, Iwata T, Higashijima J, Chikakiyo M, Nishi M, Kashihara H, Takasu C, Matsumoto N, Eto S
    • Journal Title

      Surg Endosc.

      Volume: 印刷中 Issue: 6 Pages: 1774-1778

    • DOI

      10.1007/s00464-013-3384-7

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hybrid technique for laparoscopic incisional ventral hernia repair combining laparoscopic primary closure and mesh repair.2014

    • Author(s)
      Yoshikawa K, Shimada M, Kurita N, Sato H, Iwata T, Higashijima J, Chikakiyo M, Nishi M, Kashihara H, Takasu C, Matsumoto N, Eto S
    • Journal Title

      Hybrid technique for laparoscopic incisional ventral hernia repair combining laparoscopic primary closure and mesh repair.

      Volume: 7 Issue: 3 Pages: 282-285

    • DOI

      10.1111/ases.12113

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] がん幹細胞制御におけるSonic Hedgehog signalingの役割2015

    • Author(s)
      中尾 寿宏
    • Organizer
      第101回日本消化器病学会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 癌幹細胞制御におけるSonic Hedgehog signalingの役割2014

    • Author(s)
      東島潤, 島田光生, 栗田信浩, 佐藤宏彦, 岩田貴, 吉川幸造, 近清素也, 西正暁, 柏原秀也, 松本規子
    • Organizer
      第100回日本消化器病学会総会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2014-04-23 – 2014-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒト脂肪由来幹細胞による肝傷害軽減効果に関する基礎的検討2013

    • Author(s)
      齋藤裕, 島田光生, 宇都宮徹, 池本哲也, 山田眞一郎, 石川大地, 岩橋衆一, 金本真美, 荒川悠佑, 森大樹, 森根裕二, 居村暁
    • Organizer
      第49回 日本移植学会総会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2013 Research-status Report
  • [Presentation] 脂肪由来幹細胞の傷害肝へのホーミング効果―癌幹細胞転移メカニズムへの応用―2013

    • Author(s)
      齋藤裕, 島田光生, 宇都宮徹, 池本哲也, 山田眞一郎, 森根裕二, 居村暁, 森大樹, 荒川悠佑, 金本真美, 岩橋衆一, 髙須千絵,
    • Organizer
      第72回 日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 癌幹細胞の治療抵抗性獲得におけるepigenetic修飾の意義2013

    • Author(s)
      岩橋衆一, 島田光生, 宇都宮徹, 居村暁, 森根裕二, 池本哲也, 荒川悠佑, 金本真美, 齋藤裕, 石川大地
    • Organizer
      第72回 日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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