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The Elucidation of an Immune Escape Mechanism and its control in Gastrointestinal Cancers

Research Project

Project/Area Number 25461955
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionKagoshima University

Principal Investigator

Arigami Takaaki  鹿児島大学, 医歯学域医学部・歯学部附属病院, 助教 (40527058)

Co-Investigator(Kenkyū-buntansha) UENOSONO YOSHIKAZU  鹿児島大学, 医歯学総合研究科, 特任准教授 (60398279)
NATSUGOE SHOJI  鹿児島大学, 医歯学域医学系, 教授 (70237577)
OKUBO Keishi  鹿児島大学, 医学部・歯学部附属病院, 医員 (40772223)
石神 純也  鹿児島大学, 医歯(薬)学総合研究科, 客員研究員 (90325803)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords癌免疫機構 / 好中球リンパ球比 / Fibrinogen / 全身性炎症反応 / 胃癌 / 免疫回避機構 / 免疫応答 / T細胞性免疫応答 / 免疫補助刺激分子 / CD3 / infiltrating lymphocytes
Outline of Final Research Achievements

We focused on CD3+ tumor-infiltrating lymphocytes (CD3+ TILs), neutrophil-lymphocyte ratio (NLR), and fibrinogen in this study. The numbers of CD3+ TILs in patients with gastric cancer were lower than those in gastric adenoma. Moreover, CD3+ TILs was inversely correlated with tumor progression and prognosis in patients with gastric cancer. On the other hand, the values of NLR and fibrinogen were significantly correlated with advanced disease. Patients with high NLR and fibrinogen status had poorer prognosis than those with low status. Consequently, our findings suggest that the systemic inflammatory response induced by tumor cells suppress host immune response and its escape mechanism from host immune surveillance produces tumor invasion and metastases.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (26 results)

All 2016 2015 2014 2013 2012

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Acknowledgement Compliant: 4 results) Presentation (13 results) Book (5 results)

  • [Journal Article] Combined fibrinogen concentration and neutrophil-lymphocyte ratio as a prognostic marker of gastric cancer2016

    • Author(s)
      Takaaki Arigami
    • Journal Title

      Oncology Letters

      Volume: 11 Issue: 2 Pages: 1537-1544

    • DOI

      10.3892/ol.2015.4049

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A Novel Scoring System Based on Fibrinogen and the Neutrophil-Lymphocyte Ratio as a Predictor of Chemotherapy Response and Prognosis in Patients with Advanced Gastric Cancer2016

    • Author(s)
      Takaaki Arigami
    • Journal Title

      Oncology

      Volume: 90 Issue: 4 Pages: 1977-84

    • DOI

      10.1159/000444494

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Analysis of the Fibrinogen and Neutrophil-Lymphocyte Ratio in Esophageal Squamous Cell Carcinoma: A Promising Blood Marker of Tumor Progression and Prognosis.2015

    • Author(s)
      Arigami T, Okumura H, Matsumoto M, Uchikado Y, Uenosono Y, Kita Y, Owaki T, Mori S, Kurahara H, Kijima Y, Ishigami S, Natsugoe S
    • Journal Title

      Medicine

      Volume: 94 Issue: 42 Pages: 1702-1702

    • DOI

      10.1097/md.0000000000001702

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combined fibrinogen score and neutrophil-lymphocyte ratio as prognostic marker of gastric cancer2015

    • Author(s)
      Takaaki Arigami
    • Journal Title

      Oncology Letters

      Volume: 未定

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Decreased density of CD3+ tumor-infiltrating lymphocytes during gastric cancer progression2014

    • Author(s)
      Takaaki Arigami
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: 29 Issue: 7 Pages: 1435-1441

    • DOI

      10.1111/jgh.12551

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Clinical significance of stanniocalcin 2 expression as a predictor of tumor progression in gastric cancer2013

    • Author(s)
      Takaaki Arigami
    • Journal Title

      Oncology Reports

      Volume: 30 Issue: 6 Pages: 2838-2844

    • DOI

      10.3892/or.2013.2775

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Feasibility of sentinel node navigation surgery after noncurative endoscopic resection for early gastric cancer2013

    • Author(s)
      Takaaki Arigami
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: 28 Issue: 8 Pages: 1343-1347

    • DOI

      10.1111/jgh.12269

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical Significance of Lymph Node Micrometastasis in Gastric Cancer2012

    • Author(s)
      Arigami T, Uenosono Y, Yanagita S, Nakajo A, Ishigami S, Okumura H, Kijima Y, Ueno S, Natsugoe S
    • Journal Title

      Ann Surg Oncol

      Volume: 20 Issue: 2 Pages: 515-21

    • DOI

      10.1245/s10434-012-2355-x

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 胃癌における免疫チェックポイント分子B7-H4発現の臨床的意義と個別化治療への展開2015

    • Author(s)
      有上貴明
    • Organizer
      第26回日本消化器癌発生学会総会
    • Place of Presentation
      米子全日航ホテル(鳥取県米子市)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 切除不能・再発胃癌に対する新たな術前治療効果予測バイオマーカーの検索:治療前Fibrinogen値とNeutrophil-Lymphocyte Ratioに基づいた新規スコア―の臨床的意義2015

    • Author(s)
      有上貴明
    • Organizer
      第23回日本消化器関連学会週間 (JDDW)
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 胃癌における術前Fibrinogen値とNeutrophil-Lymphocyte Ratioに基づいた新たな予後マーカーの臨床的意義2015

    • Author(s)
      有上貴明
    • Organizer
      第70回日本消化器外科学会総会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2015-07-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Clinical significance of a novel prognostic marker based on the combined score of fibrinogen and neutrophil-lymphocyte ratio in gastric cancer -Comparison with modified Glasgow Prognostic Score-2015

    • Author(s)
      Takaaki Arigami
    • Organizer
      第70回日本消化器外科学会総会
    • Place of Presentation
      浜松市(アクトシティ浜松)
    • Year and Date
      2015-07-15 – 2015-07-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 食道扁平上皮癌における血清Fibrinogen値とNeutrophil-lymphocyte ratioの臨床的意義2015

    • Author(s)
      有上貴明
    • Organizer
      第69回日本食道学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-07-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] Combined Analysis of Fibrinogen and Neutrophil-Lymphocyte Ratio in Gastric Cancer: A Promising Blood Marker for Predicting Tumor Progression and Prognosis2015

    • Author(s)
      Takaaki Arigami
    • Organizer
      11th International Gastric Cancer Congress
    • Place of Presentation
      Sao Paulo, Brazil
    • Year and Date
      2015-06-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 胃癌に対する術前血清Fibrinogen値とNeutrophil-Lymphocyte Ratioに基づくスコア―の臨床的意義:modified Glasgow Prognostic Scoreとの比較検討2015

    • Author(s)
      有上貴明
    • Organizer
      第36回癌免疫外科研究会
    • Place of Presentation
      奄美市(奄美観光ホテル)
    • Year and Date
      2015-05-15
    • Related Report
      2014 Research-status Report
  • [Presentation] 胃癌における術前血清Fibrinogen値とNeutrophil-Lymphocyte Ratioの臨床的意義2015

    • Author(s)
      有上貴明
    • Organizer
      第87回日本胃癌学会総会
    • Place of Presentation
      広島市(リーガロイヤルホテル広島)
    • Year and Date
      2015-03-06
    • Related Report
      2014 Research-status Report
  • [Presentation] 胃癌における免疫補助刺激分子B7-H3およびB7-H4発現の臨床的意義と個別化治療への可能性2014

    • Author(s)
      有上貴明
    • Organizer
      第35回癌免疫外科研究会
    • Place of Presentation
      大阪府(シェトラン都ホテル大阪)
    • Year and Date
      2014-05-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 胃癌におけるCD3腫瘍浸潤リンパ球の臨床的意義2014

    • Author(s)
      有上貴明
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都市(国立京都国際会館)
    • Year and Date
      2014-04-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 胃癌におけるCD3腫瘍浸潤リンパ球の臨床的意義2014

    • Author(s)
      有上貴明
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都市
    • Related Report
      2013 Research-status Report
  • [Presentation] 胃癌における血中遊離癌細胞の検出とHER2発現に基づく臨床応用への展開2013

    • Author(s)
      有上貴明
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Research-status Report
  • [Presentation] 胃癌における新規バイオマーカーB7-H3およびB7-H4発現の臨床的意義と個別化治療への展開2013

    • Author(s)
      有上貴明
    • Organizer
      第22回日本がん転移学会学術集会・総会
    • Place of Presentation
      松本市
    • Related Report
      2013 Research-status Report
  • [Book] 消化器外科学レビュー 最新主要文献と解説 2015-,162015

    • Author(s)
      有上貴明
    • Publisher
      総合医学社
    • Related Report
      2015 Annual Research Report
  • [Book] 臨床外科2015

    • Author(s)
      有上貴明
    • Publisher
      医学書院
    • Related Report
      2015 Annual Research Report
  • [Book] SURGERY FRONTIER2015

    • Author(s)
      有上貴明
    • Publisher
      メディカルレビュー社
    • Related Report
      2015 Annual Research Report
  • [Book] Navigation Surgery 消化器外科学レビュー 最新主要文献と解説2015

    • Author(s)
      有上貴明、夏越祥次
    • Publisher
      総合医学社
    • Related Report
      2014 Research-status Report
  • [Book] 胃全摘術後の再建の基本―Roux-en-Yか空腸間置か2015

    • Author(s)
      有上貴明、石神純也、上之園芳一、柳田茂寛、有留邦明、夏越祥次
    • Publisher
      医学書院
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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