Prevention of postoperative graft failure for liver transplantation with small for size steatite graft

• Project/Area Number: 25461967
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Kyoto University (2014-2015); The Tazuke Kofukai (2013)
• Principal Investigator: IIDA TAKU 京都大学, 医学(系)研究科(研究院), 研究員 (90437111)
• Co-Investigator(Kenkyū-buntansha): MORI Akira 京都大学, 医学(系)研究科, 講師 (60324646) ; KAIDO Toshimi 京都大学, 医学(系)研究科, 准教授 (80314194)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 脂肪肝 / 肝移植 / 肝再生 / NAFLD / marginal graft / 脂肪肝グラフト / 過小グラフト

Outline of Final Research Achievements

We evaluated the effect of statin in liver transplantation rat models using small for size steatotic grafts. In serological findings, serum AST level on POD 3,hyaluronic acid level on POD 7 of statin group were lower than those of control group. Serum triglyceride level on POD 7 of statin group was significantly lower than that of control group. Pathological findings revealed that peri-portal inflammation was inhibited in statin group. However steatosis was recovered within 7 days after liver transplantation in both groups.
This study demonstrated that statin might have the reductive effect of reperfusion injury and liver fibrosis in the early phase after liver transplantation potentially.
It must be necessary to continue the further evaluation of detailed mechanism of statin in liver transplantation.

Research Products

• [Journal Article] Impact of the preoperative quantity and quality of skeletal muscle on outcomes after resection of extrahepatic biliary malignancies. (2016)
  • Author(s): Okumura S, Kaido T, Hamaguchi Y, Fujimoto Y, Kobayashi A, Iida T, Yagi S, Taura K, Hatano E, Uemoto S.
  • Journal Title: Surgery Volume: 159 Issue: 3 Pages: 821-833
  • DOI: 10.1016/j.surg.2015.08.047
  • Peer Reviewed / Open Access
• [Journal Article] Left lobe graft poses a potential risk of hepatic venous outflow obstruction in adult living donor liver transplantation. (2016)
  • Author(s): Kitajima T, Kaido T, Iida T, Yagi S, Fujimoto Y, Ogawa K, Mori A, Okajima H, Imamine R, Shibata T, Uemoto S.
  • Journal Title: Liver Transpl. Volume: 1 Issue: 6 Pages: 1-1
  • DOI: 10.1002/lt.24399
  • Peer Reviewed / Open Access
• [Journal Article] Bundled strategies against infection after liver transplantation: Lessons from multidrug-resistant Pseudomonas aeruginosa. (2016)
  • Author(s): Sato A, Kaido T, Iida T, Yagi S, Hata K, Okajima H, Takakura S, Ichiyama S, Uemoto S.
  • Journal Title: Liver Transpl. Volume: 4 Issue: 4 Pages: 436-45
  • DOI: 10.1002/lt.24407
  • Peer Reviewed / Open Access
• [Journal Article] Oral administration of polyamines ameliorates liver ischemia-reperfusion injury and promotes liver regeneration in rats. (2016)
  • Author(s): Okumura S, Teratani T, Fujimoto Y, Zhao X, Tsuruyama T, Masano Y, Kasahara N, Iida T, Yagi S, Uemura T, Kaido T, Uemoto S.
  • Journal Title: Liver Transplantation Volume: XXX Issue: 9 Pages: 1-1
  • DOI: 10.1002/lt.24471
  • Peer Reviewed / Open Access
• [Journal Article] Portal vein reconstruction in adult living donor liver transplantation for patients with portal vein thrombosis in single center experience. (2015)
  • Author(s): Mori A, Iida T, Iwasaki J, Ogawa K, Fujimoto Y, Uemura T, et al.
  • Journal Title: J Hepatobiliary Pancreat Sci. Volume: 6 Issue: 6 Pages: 467-74
  • DOI: 10.1002/jhbp.235
  • Peer Reviewed / Open Access
• [Journal Article] Significance of (99m)Tc-GSA liver scintigraphy in liver surgery and transplantation. (2015)
  • Author(s): Iida T, Yagi S, Hori T, Uemoto S
  • Journal Title: Ann Transl Med. Volume: 2 Pages: 16-16
  • Peer Reviewed / Open Access
• [Journal Article] Ultraviolet-induced alloantigen-specific immunosuppression in transplant immunity. (2015)
  • Author(s): Hori T, Kuribayashi K, Saito K, Wang L, Torii M, Uemoto S, Iida T, Yagi S, Kato T.
  • Journal Title: World J Transplant Volume: 5 Issue: 1 Pages: 11-18
  • DOI: 10.5500/wjt.v5.i1.11
  • Peer Reviewed / Open Access
• [Journal Article] aroscopic Distal Pancreatectomy with or without Preservation of the Spleen for Solid Pseudopapillary Neoplasm. (2015)
  • Author(s): Hori T, Masui T, Kaido T, Ogawa K, Yasuchika K, Yagi S, Seo S, Takaori K, Mizumoto M, Iida T, Fujimoto Y, Uemoto S.
  • Journal Title: Case Rep Surg. Volume: 1 Pages: 1-17
  • DOI: 10.1155/2015/487639
  • Peer Reviewed / Open Access
• [Journal Article] 当院での腹腔鏡下脾臓摘出術の検討 術後門脈血栓症の治療と予防について (2015)
  • Author(s): 飯田 拓, 寺嶋 宏明, 内田 洋一朗, 上田 修吾, 金澤 旭宣
  • Journal Title: 臨床外科 Volume: 70 Pages: 340-343
  • Peer Reviewed
• [Journal Article] 肝門部Glisson鞘と広汎に接する肝細胞癌に対して中央二区域切除術を施行した1例 (2015)
  • Author(s): 寺嶋 宏明, 飯田 拓, 岩村 宣亜, 内田 洋一朗
  • Journal Title: 手術 Volume: 69 Pages: 315-319
  • Peer Reviewed
• [Journal Article] Impact of preoperative uncontrollable hepatic hydrothorax and massive ascites in adult liver transplantation. (2014)
  • Author(s): Endo K, Iida T, Yagi S, Yoshizawa A, Fujimoto Y, Ogawa K, Ogura Y, Mori A, Kaido T, Uemoto S.
  • Journal Title: Surg Today. Volume: 44 Issue: 12 Pages: 2293-9
  • DOI: 10.1007/s00595-014-0839-y
  • NAID: 120005682547
  • Peer Reviewed / Open Access
• [Journal Article] How to successfully resect 70 % of the liver in pigs to model an extended hepatectomy with an insufficient remnant or liver transplantation with a small-for-size graft. (2014)
  • Author(s): Hori T, Yagi S, Okamua Y, Iida T, Ogawa K, Tanaka H, Kageyama S, Hirao H, Hata T, Kirino I, Nagai K, Kubora T, Jobara K, Endo K, Uemoto S.
  • Journal Title: Surg Today. Volume: 44 Issue: 11 Pages: 2201-7
  • DOI: 10.1007/s00595-014-0862-z
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Donor morbidity in right and left hemiliver living donor liver transplantation: the impact of graft selection and surgical innovation on donor safety. (2014)
  • Author(s): Iwasaki J, Iida T, Mizumoto M, Uemura T, Yagi S, Hori T, Ogawa K, Fujimoto Y, Mori A, Kaido T, Uemoto S.
  • Journal Title: Transpl Int. Volume: 27 Issue: 11 Pages: 1205-13
  • DOI: 10.1111/tri.12414
  • Peer Reviewed / Open Access
• [Journal Article] Hepatic arterial complications in adult living donor liver transplant recipients: a single-center experience of 673 cases. (2014)
  • Author(s): Iida T, Kaido T, Yagi S, Hori T, Uchida Y, Jobara K, Tanaka H, Sakamoto S, Kasahara M, Ogawa K, Ogura Y, Mori A, Uemoto S.
  • Journal Title: Clin Transplant. Volume: 28 Issue: 9 Pages: 1025-30
  • DOI: 10.1111/ctr.12412
  • Peer Reviewed / Open Access
• [Journal Article] Impact of preoperative uncontrollable hepatic hydrothorax and massive ascites in adult liver transplantation. (2014)
  • Author(s): Endo K, Iida T, Yagi S, Yoshizawa A, Fujimoto Y, Ogawa K, Ogura Y, Mori A, Kaido T, Uemoto S.
  • Journal Title: Surg Today. Volume: Feb 8
  • NAID: 120005682547
  • Peer Reviewed
• [Journal Article] Predictive factors for reintubation following noninvasive ventilation in patients with respiratory complications after living donor liver transplantation. (2013)
  • Author(s): Chihara Y, Egawa H, Oga T, Tsuboi T, Handa T, Yagi S, Iida T, Yoshizawa A, Yamamoto K, Mishima M, Tanaka K, Uemoto S, Chin K.
  • Journal Title: PLoS One. Volume: 8 Issue: 12 Pages: e81417-e81417
  • DOI: 10.1371/journal.pone.0081417
  • NAID: 120005372923
  • Peer Reviewed
• [Journal Article] Effects of oral intake of hydrogen water on liver fibrogenesis in mice (2013)
  • Author(s): Koyama Y, Taura K, Hatano E, Tanabe K, Yamamoto G, Nakamura K, Yamanaka K, Kitamura K, Narita M, Nagata H, Yanagida A, Iida T, Iwaisako K, Fujinawa H, Uemoto S
  • Journal Title: Hepatol Res Volume: May 20 Issue: 6 Pages: 663-677
  • DOI: 10.1111/hepr.12165
  • Peer Reviewed
• [Journal Article] Malignant pheochromocytoma: Hepatectomy for liver metastases. (2013)
  • Author(s): Hori T, Yamagiwa K, Hayashi T, Yagi S, Iida T, Taniguchi K, Kawarada Y, Uemoto S.
  • Journal Title: World J Gastrointest Surg. Volume: 5(11) Pages: 309-13
  • Peer Reviewed
• [Journal Article] How do transplant surgeons accomplish optimal portal venous flow during living-donor liver transplantation? Noninvasive measurement of indocyanine green elimination rate. (2013)
  • Author(s): Hori T, Yamagiwa K, Hayashi T, Yagi S, Iida T, Taniguchi K, Kawarada Y, Uemoto S.
  • Journal Title: World J Gastrointest Surg. Volume: 5(11) Pages: 309-13
  • Peer Reviewed
• [Presentation] 膵頭部領域癌に対する膵頭十二指腸切除術式の変遷:SMA first approachとBlumgart変法の治療成績について (2015)
  • Author(s): 飯田 拓、寺嶋宏明、内田洋一朗、松原弘侑、後藤 徹 岩村宣亜、井上善景、吉冨摩美、上田修吾、金澤旭宣
  • Organizer: 第70回日本消化器外科学会総会
  • Place of Presentation: 浜松
  • Year and Date: 2015-07-16
• [Presentation] 肝中央2区域切除およびS4+前区域腹側切除の検討 (2015)
  • Author(s): 飯田拓、寺嶋宏明、内田洋一朗、松原弘侑、後藤徹、岩村宣亜
  • Organizer: 第27回日本肝胆膵外科学会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-06-11
• [Presentation] 脳死肝移植グラフトの術前質的評価について：脳死肝移植におけるゼロバイオプシ ーの病理診断乖離例の検討 (2015)
  • Author(s): 飯田 拓、海道利実、堀智英、八木眞太郎、吉澤 淳、秦浩一郎、藤本康弘、小川晃平、森 章、岡島英明、宮川 文、南口早智子、 羽賀博典、上本伸二
  • Organizer: 第33回日本肝移植研究会
  • Place of Presentation: 神戸
  • Year and Date: 2015-05-28
• [Presentation] 大腸癌両葉多発肝転移に対する集学的治療の成績：有用性と問題点について (2015)
  • Author(s): 飯田 拓、寺嶋宏明、内田洋一朗、松原弘侑、後藤 徹 岩村宣亜、井上善景、吉冨摩美、上田修吾、金澤旭宣
  • Organizer: 第115回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-04-16
• [Presentation] 腹腔鏡下系統的肝切除術の手術手技確立に向けて：対策と課題について (2014)
  • Author(s): 飯田 拓、寺嶋宏明、内田洋一朗、松原弘侑、後藤徹、岩村宣亜、井上善景、吉冨摩美、上田修吾、金澤旭宣
  • Organizer: 第27回日本内視鏡外科学会総会
  • Place of Presentation: 盛岡市
  • Year and Date: 2014-10-02 – 2014-10-04
• [Presentation] Clinical outcome of adjuvant liver surgery for “Unresectable colorectal liver metastases" (2014)
  • Author(s): Taku Iida , Hiroaki Terajima, Youichiro Uchida
  • Organizer: 6th International Forum of Liver Surgery
  • Place of Presentation: Wilsede, Germany
  • Year and Date: 2014-08-15 – 2014-08-17
• [Presentation] 肝亜区域切除術における術式のポイント:過不足のない切除範囲と安全性を目指して (2014)
  • Author(s): 飯田 拓、寺嶋 宏明、内田 洋一朗、岩村 宣亜、川本 浩史、戸田 怜、井上 善景、吉冨 摩美、上田 修吾、金澤 旭宣
  • Organizer: 第69回日本消化器外科学会総会
  • Place of Presentation: 郡山市
  • Year and Date: 2014-07-16 – 2014-07-18
• [Presentation] 当科での腹腔鏡下肝切除術の変遷と現状：完全腹腔鏡下系統的肝切除を目指して (2014)
  • Author(s): 飯田拓、、寺嶋宏明、内田洋一朗、後藤徹、岩村宣亜、川本浩史、戸田怜、 井上善景、吉冨摩美、上田修吾、金澤旭宣
  • Organizer: 第26回日本肝胆膵外科学会
  • Place of Presentation: 和歌山市
  • Year and Date: 2014-06-11 – 2014-06-13
• [Presentation] 術前化学療法が大腸癌肝転移症例の術前肝機能に及ぼす影響について (2014)
  • Author(s): 飯田拓、寺嶋宏明、内田洋一朗、後藤徹、岩村宣亜、川本浩史、戸田怜、井上善景、吉冨摩美、上田修吾、金澤旭宣
  • Organizer: 第114回日本外科学会定期学術集会
  • Place of Presentation: 京都市
  • Year and Date: 2014-04-03 – 2014-04-05
• [Presentation] Impact of neoadjuvant chemoradiotherapy for borderline resectable and non-resectable pancreatic cancer (2014)
  • Author(s): T. Iida, H. Terajima, Y. Uchida, H. Kawamoto, R. Toda, Y. Inoue, M. Yoshitomi, S. Ueda, and A. Kanazawa
  • Organizer: 11th World Congress of the International Hepato-Pancreato-Biliary Association
  • Place of Presentation: Seoul, Korea
• [Presentation] Clinical impact of anatomical liver resection for solitary hepatocellular carcinoma (2013)
  • Author(s): Taku Iida, Hiroaki Terajima, Yoichiro Uchida, Shugo Ueda
  • Organizer: Digestive Disease Week (DDW) 2013
  • Place of Presentation: Orlando, USA
• [Presentation] 肝細胞癌に対する系統的肝切除の臨床的意義：非系統的切除との使い分けは可能か (2013)
  • Author(s): 飯田拓、寺嶋宏明、内田洋一朗、岩村宣亜、川本浩史、戸田怜、井上善景、門野賢太郎、吉冨摩美、野村明成、上田修吾
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡、福岡国際会館
• [Presentation] 肝動脈・門脈合併切除を伴う肝切除術での工夫：残肝の完全血行遮断回避のための門脈先行再建について (2013)
  • Author(s): 飯田拓、寺嶋宏明、内田洋一朗、岩村宣亜、川本浩史、井上善景、門野賢太郎、吉冨摩美
  • Organizer: 第25回日本肝胆膵外科学会
  • Place of Presentation: 宇都宮、ホテル東日本宇都宮
• [Presentation] Conversion chemotherapy施行後に切除可能となった肝内胆管癌に対する右肝動脈・門脈合併肝拡大左葉切除術 (2013)
  • Author(s): 飯田 拓、寺嶋 宏明、内田 洋一朗、川本 浩史、井上 善景、門野 賢太郎、吉冨 摩美、野村 明成、上田 修吾
  • Organizer: 第68回日本消化器外科学会
  • Place of Presentation: 宮崎、シーガイアホテル