|Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|Outline of Final Research Achievements
Pathological finding "Tumor budding" in esophageal cancer has significant correlation to the prognosis of the patients under went esophagectomy. WE focused on EMT (Epithelial to mesenchymal transition). The EMT status and expression of related protein significantly correlate to the status of tumor budding. These findings suggested EMT could have a role in the genesis of Tumor budding.
On the other hand, expression of L1CAM using rt-PCR and Western blotting was investigated in the same specimens. However, there was no significant relation between expression of L1CAM and the prognosis of the patients. Unlike in gastric cancer, L1CAM is not a useful prognostic factor for esophageal cancer.