• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Novel treatment for chromothripsis in breast cancer

Research Project

Project/Area Number 25461978
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionNagoya University

Principal Investigator

Tsunoda Nobuyuki  名古屋大学, 医学部附属病院, 病院講師 (40542684)

Co-Investigator(Kenkyū-buntansha) NAGINO MASATO  名古屋大学, 医学系研究科, 教授 (20237564)
YOKOYAMA YUKIHIRO  名古屋大学, 医学部附属病院, 講師 (80378091)
KOKURYO TOSHIO  名古屋大学, 医学系研究科, 特任講師 (60378023)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsChromothripsis
Outline of Final Research Achievements

Chromothripsis has not been identified in breast cancer and bone tumor cell lines. Anti-cancer agents are not able to induce chromothripsis in cancer cell lines, including breast, colorectal and pancreatic cancer cell lines.
Fusion genes are a genetic variation similar to chromothripsis.We identified several fusion genes, including two non-coding RNAs (LOC642236 and LOC283788). Because there are no fusion genes in normal cells, fusion genes are an appropriate target for molecular targeted therapy; therefore, novel treatment therapies involving the above fusion genes are expected in the future.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi