Detection and application of the alteration in background liver with hepatocellular carcinoma utilizing multi array methods
Project/Area Number |
25461979
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General surgery
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Research Institution | Aichi Gakuin University (2014-2015) Nagoya University (2013) |
Principal Investigator |
Nomoto Shuji 愛知学院大学, 歯学部, 教授 (40300967)
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Co-Investigator(Kenkyū-buntansha) |
SUGIMOTO Hiroyuki 名古屋大学, 医学系研究科, 講師 (20437007)
KANDA Mitsuro 名古屋大学, 医学部附属病院, 助教 (00644668)
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Research Collaborator |
INOKAWA Yoshikuni
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | マルチアレイ法 / 発現アレイ / SNPアレイ / メチル化アレイ / MicroRNAアレイ |
Outline of Final Research Achievements |
When assessing hepatocellular carcinoma (HCC), it is important to examine prognostic factors in the background normal liver tissue and consider malignant aspects of the primary lesion. Control samples, termed supernormal (SN) liver, were taken from 11 cases of metastatic secondary malignancies of the liver. We selected adjacent nonneoplastic liver tissue from a patient with HCC and liver cirrhosis by hepatitis C (CN) for comparison. Expression profiling and methylation arrays were performed. We identified genes showing differences in both arrays. The alteration of those genes’ expression in corresponding background liver demonstrated significant correlation with worse survival. Expression of these genes in the background liver of HCC is likely to be a good biomarker for risk of HCC development. When assessing HCC, it is important to extract prognostic factors from background liver tissue as well as considering malignant factors of the primary cancer lesion.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] High expression of Janus kinase 2 in background normal liver tissue of resected hepatocellular carcinoma is associated with worse prognosis2015
Author(s)
Fuminori Sonohara, Shuji Nomoto, Yoshikuni Inokawa, Mitsuhiro Hishida, Nao Takano, Mitsuro Kanda, Yoko Nishikawa, Tsutomu Fujii, Masahiko Koike, Hiroyuki Sugimoto, Yasuhiro Kodera
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Journal Title
Oncology Reports
Volume: 33(2)
Issue: 2
Pages: 767-773
DOI
Related Report
Peer Reviewed
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[Journal Article] CCNJ detedted by triple combination array analysis as a tumor-related gene of hepatocellular carcinoma2015
Author(s)
Nao Takano,Mitsuhiro Hishida,Yoshikuni Inokawa, Masamichi Hayashi, Mitsuro Kanda, Yoko Nishikawa, Naoki Iwata, Daisuke Kobayashi, Chie Tanaka, Suguru Yamada, Goro Nakayama, Tsutomu Fujii, Hiroyuki Sugimoto, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera, Shuji Nomoto
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Journal Title
International journal of oncology
Volume: 46(5)
Issue: 5
Pages: 1963-1970
DOI
Related Report
Peer Reviewed
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[Journal Article] Expression Analysis of THOP1 in Background Liver, a Prognostic Predictive Factor in Hepatocellular Carcinoma, Extracted by Multiarray Analysis2014
Author(s)
Shuji Nomoto, Mitsuhiro Hishida, Yoshikuni Inokawa, Nao Takano, Mitsuro Kanda, Yoko Nishikawa, Tsutomu Fujii, Masahiko Koike, Hiroyuki Sugimoto, Yasuhiro Kodera
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Journal Title
Annals of Surgical Oncology
Volume: 21(suppl3)
Issue: S3
Pages: 443-450
DOI
Related Report
Peer Reviewed
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[Presentation] Alteration of aldo-keto reductase family 1, member B10(AKR1B10) expression among tumor and background non-tumorous tissue of curatively resected hepatocellular carcinoma is associated with worse prognosis.2015
Author(s)
Shuji Nomoto, Fuminori Sonohara, Yoshikuni Inokawa, Mitsuro Kanda, Tsutomu Fujii, Hiroyuki Sugimoto, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera
Organizer
AACR Annual Meeting 2015 (American Association for Cancer Research)
Place of Presentation
Philadelphia,PA,USA
Year and Date
2015-04-18
Related Report
Int'l Joint Research
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[Presentation] ZGPAT gene expression in non-tumor hepatocellular carcinoma tissue is a likely biomarker for survival risk2014
Author(s)
Mitsuhiro Hishida, Shuji Nomoto, Yoshikuni Inokawa, Nao Takano, Mitsuro Kanda, Naoki Iwata, Chie Tanaka, Daisuke Kobayashi, Yoko Nishikawa, Suguru Yamada, Goro Nakayama, Tsutomu Fujii, Hiroyuki Sugimoto, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera
Organizer
AACR Annual Meeting 2014 (American Association for Cancer Research)
Place of Presentation
San Diego, CA
Year and Date
2014-04-05 – 2014-04-09
Related Report
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[Presentation] Correlation between worse prognosis and lower expression of the TPPP gene in patients with hepatocellular carcinoma, detected by multiarray analysis2014
Author(s)
Yoshikuni Inokawa, Shuji Nomoto, Mitsuhiro Hishida, Nao Takano, Mitsuro Kanda, Michitaka Fujiwara, Masahiko Koike, Hiroyuki Sugimoto, Tsutomu Fujii, Goro Nakayama, Suguru Yamada, Chie Tanaka, Daisuke Kobayashi, Naoki Iwata, Yasuhiro Kodera
Organizer
AACR Annual Meeting 2014 (American Association for Cancer Research)
Place of Presentation
San Diego, CA
Year and Date
2014-04-05 – 2014-04-09
Related Report
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