Experimental and clinical study for free dermal fat grafting technique during breast conserving surgery in patients with breast cancer.

• Project/Area Number: 25461986
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Kagoshima University
• Principal Investigator: Kijima Yuko 鹿児島大学, 医歯学域医学部・歯学部附属病院, 講師 (60381175)
• Co-Investigator(Kenkyū-buntansha): HIRATA MUNETUGU 鹿児島大学, 医歯学域医学部・歯学部附属病院, 医員 (00649072) ; NAKAJO AKIHIRO 鹿児島大学, 医歯学域医学部・歯学部附属病院, 助教 (20404486) ; NATSUGOE SHOJI 鹿児島大学, 医歯学域医学系, 教授 (70237577) ; SHINDEN YOSHIAKI 鹿児島大学, 医歯学域医学部・歯学部附属病院, 医員 (20725733) ; ARIMA HIDEO 鹿児島大学, 医歯学域医学部・歯学部附属病院, 助教 (90418856) ; 石神 純也 鹿児島大学, 医歯(薬)学総合研究科, 客員研究員 (90325803)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 乳癌 / 乳房温存手術 / 遊離真皮脂肪片 / 整容性 / oncoplastic Surgery / oncoplastic surgery

Outline of Final Research Achievements

①We made an rat model and clarified free dermis fat single (FDFG) survival mechanism scientifically. [Mizoguchi T, et al.Surgery Today (2014:22)]. There was significantly fewer apoptosis and more VEGF-positive cells in the FDFG group. Attached dermis would play an important role in a vascularization and the prevention of apoptosis.
②We revealed the risk factor of postoperative complication in FDFG implanted cases. [Kijima Y, et al. Gland Surgery 2015(4)]. This study were clinically done as a multi-institutional joint research in Japan and it is the first report in the wolrd to discuss the risk factor and indication for this operation using multi-institutional data.

Research Products

• [Journal Article] Impaired wound healing and expansion of a large ulcer in a patient with skin metastases on the anterior chest wall from breast cancer after an injection of bevacizumab with paclitaxel. (2015)
  • Author(s): Yuko Kijima, Heiji Yoshinaka, Munetsugu Hirata, Akihiro Nakajo, Hideo Arima, Yoshiaki Shinden, Tetsuya Ijichi, Yuka Eguchi, Hiroshi Okumura, Yoshikazu Uenosono, Hiroshi Kurahara, Sumiya Ishigami and Shoji Natsugoe.
  • Journal Title: Surgery Today Volume: 45 Issue: 4 Pages: 498-502
  • DOI: 10.1007/s00595-014-0912-6
  • Peer Reviewed / Open Access
• [Journal Article] Immediate breast volume replacement using a free dermal fat graft after breast cancer surgery: Multi-institutional joint research of short-term outcomes in 262 Japanese patients. (2015)
  • Author(s): Kijima Y, Koriyama C, Fujii T, Hirokaga K, Ishigure K, Kaneko T, Kayano S, Miyamoto S, Sagara Y, Sakurai T, Sakurai T, Sotome K, Ueo H, Wakit K, and Watatani M.
  • Journal Title: Gland Surgery Volume: 4(2) Pages: 179-194
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Oncoplastic surgery in a Japanese patient with breast cancer in the lower inner quadrant area: partial mastectomy using horizontal reduction mammoplasty. (2014)
  • Author(s): Kijima Y, Yoshinaka H, Hirata M, Mizoguchi T, Ishigami S, Nakajo A, Arima H, Ueno S, Natsugoe S.
  • Journal Title: Breast Cancer Volume: 21 Issue: 3 Pages: 375-378
  • DOI: 10.1007/s12282-010-0250-5
  • Peer Reviewed / Open Access
• [Journal Article] Oncoplastic breast surgery for centrally located breast cancer: a case series. (2014)
  • Author(s): Kijima Y, Yoshinaka H, Shinden Y, Hirata M, Nakajo A, Arima H, Okumura H, Kurahara H, Ishigami S, Natsugoe S.
  • Journal Title: Gland Surgery Volume: 3(1)
  • Peer Reviewed / Open Access
• [Journal Article] Oncoplastic breast surgery combining partial mastectomy with immediate breast reshaping using key hole shaped skin-glandular flap for Paget’s disease. (2014)
  • Author(s): Kijima Y, Yoshinaka H, Hirata M, Ishigami S, Nakajo A, Arima H, Arigami T, Okumura H, Natsugoe S.
  • Journal Title: Surgery Today Volume: 44 Issue: 9 Pages: 1783-1788
  • DOI: 10.1007/s00595-013-0687-1
  • Peer Reviewed / Open Access
• [Journal Article] Oncoplastic surgery combining partial mastectomy and immediate volume replacement using a thoracodorsal adipofascial cutaneous flap with a crescent-shaped dermis. (2014)
  • Author(s): Kijima Y, Yoshinaka H, Hirata M, Arima H, Nakajo A, Shinden Y, Uenosono Y, Okumura H, Ishigami S, Natsugoe S.
  • Journal Title: Surgery Today Volume: 44 Issue: 11 Pages: 2098-2105
  • DOI: 10.1007/s00595-013-0812-1
• [Journal Article] Immediate reconstruction using a modified inframammary adipofascial flap after partial mastectomy. (2013)
  • Author(s): Kijima Y,et al.
  • Journal Title: Surgery Today. Volume: 43(4) Issue: 4 Pages: 456-460
  • DOI: 10.1007/s00595-012-0390-7
  • NAID: 10031168037
  • Peer Reviewed
• [Journal Article] mmediate volume replacement using modified free dermal fat graft from lateral abdomen for a patient with early breast cancer. (2013)
  • Author(s): Kijima Y, Yoshinaka H, Hirata M, Ishigami S, Nakajo A, Arima H, Arigami T, Okumura H, Natsugoe S.
  • Journal Title: Int Canc Conf J. Volume: 82 Pages: 101-106
  • Peer Reviewed
• [Journal Article] Histological findings of a local adipofascial flap that was implanted during breast conserving surgery. (2013)
  • Author(s): Kijima Y, Yoshinaka H, Hirata M, Nakajo A, Arima H, Ishigami S, Ueno S, Natsugoe S.
  • Journal Title: Modern Plastic Surgery Volume: 3 Issue: 01 Pages: 43-46
  • DOI: 10.4236/mps.2013.31008
  • Peer Reviewed
• [Journal Article] Oncoplastic breast surgery combining periareolar mammoplasty with a crescent shaped cutaneous flap for early breast cancer in the upper quadrant area. (2013)
  • Author(s): Kijima Y, Yoshinaka H, Hirata M, Mizoguchi T, Ishigami S, Nakajo A, Arima H, Takaaki Arigami, Hiroshi Okumura, Natsugoe S.
  • Journal Title: Sugrery Today Volume: 43(8) Issue: 8 Pages: 946-953
  • DOI: 10.1007/s00595-013-0506-8
  • Peer Reviewed
• [Journal Article] 5. Kijima Y, Yoshinaka H, Hirata M, Shinden Y, Ishigami S, Nakajo A, Arima H, Arigami T, Okumura H, Natsugoe S. (2013)
  • Author(s): Kijima Y, Yoshinaka H, Hirata M, Shinden Y, Ishigami S, Nakajo A, Arima H, Arigami T, Okumura H, Natsugoe S.
  • Journal Title: Modern Plastic Surgery Volume: 3 Issue: 02 Pages: 57-64
  • DOI: 10.4236/mps.2013.32011
  • Peer Reviewed
• [Presentation] Oncoplastic breast surgery combining partial mastectomy with nipple-areola grafting for patients with early breast cancer. (2015)
  • Author(s): Kijima Y, Hirata M, Shinden Y, Nakajo A, Arima H, Yoshinaka H, Natsugoe S.
  • Organizer: FACO Surgery session 1, JSCO 53rd Annual meeting 2015
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2015-10-29
  • Int'l Joint Research
• [Presentation] Oncoplastic breast surgery combining partial mastectomy with nipple-areola grafting for patients with early breast cancer (2015)
  • Author(s): Kijima Y, Yoshinaka H, Hirata M, Shinden Y, Arima H, Nakajo A, Eguchi Y, Nomoto Y, Kurahar H, Ishigami S, Arigami T, Okumura H, Natsugoe S.
  • Organizer: ORBS 2015
  • Place of Presentation: Nottingham, UK,
  • Year and Date: 2015-09-21
  • Int'l Joint Research
• [Presentation] 乳癌のOPB：整容性と根治性の両立を目指して (2015)
  • Author(s): 喜島祐子
  • Organizer: ．第２回日本オンコプラスティックサージャリー学会総会
  • Place of Presentation: 京王プラザホテル札幌（北海道札幌市）
  • Year and Date: 2015-09-03
• [Presentation] Highlight1（レビューセッション）． (2015)
  • Author(s): 喜島祐子．
  • Organizer: 第23回日本乳癌学会学術総会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2015-07-02
• [Presentation] 乳頭乳輪の遊離移植を実施したOncoplastic breast surgery. Oncoplastic breast surgery: partial mastectomy combining with free grafting of Nipple-areola technique．パネルディスカッション (2015)
  • Author(s): 喜島祐子，吉中平次，平田宗嗣，新田吉陽，江口裕可，野元優貴，中条哲浩，有馬豪男，夏越祥次．
  • Organizer: 第115回日本外科学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-04-16
• [Presentation] 乳房縮小手技を導入したOncoplastic Breast Surgery：Free grafting of Nipple-areola. （ワークショップ）．11月20-22日 (2014)
  • Author(s): 喜島祐子，吉中平次，平田宗嗣，新田吉陽，江口裕可，野元優貴，中条哲浩，有馬豪男，夏越祥次．
  • Organizer: 第76回日本臨床外科学会学術集会
  • Place of Presentation: 郡山市(郡山市民文化センター）
  • Year and Date: 2014-11-20 – 2014-11-22
• [Presentation] 乳房縮小手技を導入したOncoplastic Breast Surgery: Free grafting of Nipple-areola (2014)
  • Author(s): 喜島祐子，平田宗嗣，中条哲浩，有馬豪男，新田吉陽，吉中平次，夏越祥次．
  • Organizer: 第2回日本乳房オンコプラスティックサージェリー学会総会
  • Place of Presentation: 東京都（ホテル日航東京）
  • Year and Date: 2014-10-02 – 2014-10-03
• [Presentation] 乳房縮小固定手技を導入したOncoplastic breast surgery（乳腺部分切除＋乳房縮小固定術） (2014)
  • Author(s): 喜島祐子，吉中平次，平田宗嗣，新田吉陽，江口裕可，野元優貴，中条哲浩，有馬豪男，夏越祥次．
  • Organizer: 第22回日本乳癌学会学術総会
  • Place of Presentation: 大阪市（大阪国際会議場）
  • Year and Date: 2014-07-10 – 2014-07-12
• [Presentation] Oncoplastic breast Surgery combining partial mastectomy with reduction mammoplasty for Japanese patients with ptotic breasts (2014)
  • Author(s): Kijima Y, Yoshinaka H, Hirata M, Nakajo A, Arima H, Eguchi Y, Nomoto Y, Shinden Y, Natsugoe S.
  • Organizer: 3rd international breast cancer symposium
  • Place of Presentation: 韓国 済州島
  • Year and Date: 2014-04-24 – 2014-04-25
• [Presentation] 下垂乳房の乳癌症例に対するOncoplastic breast surgery（乳腺部分切除＋乳房縮小固定術）． (2014)
  • Author(s): 喜島祐子，吉中平次，平田宗嗣，新田吉陽，中条哲浩，有馬豪男，夏越祥次．
  • Organizer: 第114回日本外科学会学術総会
  • Place of Presentation: 京都市（国立京都国際会館）
  • Year and Date: 2014-04-03 – 2014-04-05
• [Presentation] 乳房温存術時の術前のデザイン/術後評価．プレナリーセッション，原発巣手術と温存乳房内再発． (2013)
  • Author(s): 喜島祐子，吉中平次，平田宗嗣，中条哲浩，有馬豪男，新田吉陽，江口裕可，野元優貴，夏越祥次．
  • Organizer: 第21回日本乳癌学会学術総会
  • Place of Presentation: 浜松市
  • Invited
• [Presentation] 乳癌治療時の遊離真皮脂肪片移植法の安全性と有効性に関する研究会（FDFG研究会）．乳癌治療時の遊離真皮脂肪片移植法の安全性 －後ろ向き多施設調査の結果－． (2013)
  • Author(s): 喜島祐子，綿谷正弘，櫻井孝志，宮本幸雄，上尾裕昭，五月女恵一，石槫清，櫻井照久，相良安昭，金子朋代，藤井輝彦，茅野修史，脇田和幸，廣利浩一
  • Organizer: 第21回日本乳癌学会学術総会
  • Place of Presentation: 浜松市
• [Presentation] Oncoplastic surgery combining partial mastectomy and immediate volume replacement using a thoracodorsal adipofascial cutaneous flap with a crescent-shaped dermis (2013)
  • Author(s): Yuko Kijima, Heiji Yoshinaka, Munetsugu Hirata, Hideo Arima, Akihiro Nakajo, Yoshiaki Shinden, Takaaki Arigami, Hiroshi Okumura, Sumiya Ishigami, and9 Shoji Natsugoe.
  • Organizer: 3rd international meeting of ORBS
  • Place of Presentation: UK, Nottingham
• [Presentation] 乳房下垂の有無に着目したOncoplastic Surgeryの実践 ―乳房外組織補填術と乳房縮小固定手技の導入－． (2013)
  • Author(s): 喜島祐子，平田宗嗣，中条哲浩，有馬豪男，新田吉陽，吉中平次，夏越祥次
  • Organizer: 第１回日本乳房オンコプラスティックサージェリー学会総会，
  • Place of Presentation: 福岡市
• [Presentation] 乳房下垂の有無に着目した乳房温存療法時のOncoplastic Surgery (Oncoplastic breast surgery for a patient receiving breast conserving surgery). (2013)
  • Author(s): 喜島祐子，平田宗嗣，吉中平次，新田吉陽，野元優貴，江口裕可，中条哲浩，有馬豪男，夏越祥次.
  • Organizer: 第51回日本癌治療学会
  • Place of Presentation: 京都市
• [Presentation] 外側領域乳癌に対するOncoplastic Breast Surgery (OBS)―胸背脂肪筋膜弁による一期的欠損充填法― (2013)
  • Author(s): 喜島祐子，吉中平次，平田宗嗣，中条哲浩，有馬豪男，夏越祥次．
  • Organizer: 第75回日本臨床外科学会学術集会．
  • Place of Presentation: 名古屋市
• [Book] PEPARS 84 (2013)
  • Author(s): 喜島祐子、平田宗嗣、吉中平次、夏越祥次
  • Publisher: 全日本病院出版会