Analysis of genetic alterations in thyroid cancer in the young population.

Research Project

Project/Area Number	25461989
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	General surgery
Research Institution	Fukushima Medical University
Principal Investigator	Fukushima Toshihiko 福島県立医科大学, 医学部, 准教授 (20336457)
Co-Investigator(Kenkyū-buntansha)	SUZUKI SHINICHI 福島県立医科大学, 器官制御外科, 教授 (70235951) HAYASE SUGURU 福島県立医科大学, 器官制御外科, 助教 (00583387) 隈元謙介福島県立医科大学, 医学部, 助教 (60457778)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	甲状腺癌 / 小児甲状腺癌 / 甲状腺乳頭癌 / 小児甲状腺
Outline of Final Research Achievements	We investigated the presence of cancer driver mutations in 67 cases of thyroid cancer. Written informed consent was obtained from the parents. We detected BRAF V600E in 43 cases (63%). N, H, K-RAS mutations were not detected. These results were equal to the results in the adult study and different from post-Chernobyl thyroid cancer.