| Project/Area Number |
25462004
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UCHIYAMA Kazuhisa 大阪医科大学, 医学部, 教授 (80232867)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 乳癌 / 樹状細胞 / CD83 / CD1a / CCR6 / CCR7 / ＣＤ８３ |
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| Outline of Final Research Achievements |
Frozen tissues were obtained from all patients with breast cancer who underwent curative surgery at Osaka Medical College. The present research demonstrate that, in breast cancer tissues, the number of mature TIDCs expressing CD83 is strongly associated with prognosis compared to that of TIDCs expressing S100 or CD1a. In addition, our results showed the increased number of mature TIDCs was associated with intratumoral expression of immunosuppressive cytokines like VEGF and TGF-b.
On the other hand, we could not show the correlation between expression of CC-chemokine receptor 6 (CCR6), CC-chemokine receptor 7(CCK7) , macropharge inflammatory protein-3a(MIP-3a) and TIDCs. Finally, we could show that the infiltration of tumors by mature DCs expressing CD83 is of great importance in initiating the primary antitumor immune response and is confirmed as an independent, immunologic prognostic parameter for survival in patients with breast cancer.
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