Impact of inflammation-metaplasia-adenocarcinoma sequence and inflammatory microenvironment in esophageal carcinogenesis using surgical rat models

• Project/Area Number: 25462016
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kanazawa University
• Principal Investigator: Tomoharu Miyashita 金沢大学, 医学系, 助教 (30397210)
• Co-Investigator(Kenkyū-buntansha): Ohta Tetsuo 金沢大学, 医学系, 教授 (40194170)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 食道発癌 / 逆流性食道炎 / 腫瘍微小環境 / Valpronic acid

Outline of Final Research Achievements

Macrophages infiltrate the esophagus and activate the pStat3 pathway in stromal cells and epithelium. M2 phenotype macrophages infiltrate following infiltration of M1 macrophage and contribute to tumor development through regulatory T cells (Tregs). The involvement of immune cells such as TAMs and Tregs in the inflammatory microenvironment promotes esophageal carcinogenesis.

Research Products

• [Journal Article] Impact of histone deacetylase 1 and metastasis-associated gene 1 expression in esophageal carcinogenesis (2014)
  • Author(s): 7.Miyashita T, Tajima H, Munemoto M, Shah F, Harmon J.W, Watanabe T, Shoji M, Okamoto K, Nakanuma S, Sakai S, Kinoshita J, Makino I, Nakamura K< Hayashi H, Oyama K, Inokuchi M, Nakagawara H, Takamura H, Ninomiya I, Kitagawa H, Fushida S, Mukaisho K, Fujimur T.
  • Journal Title: Oncology Letters Volume: 8 Issue: 2 Pages: 758-764
  • DOI: 10.3892/ol.2014.2176
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Impact of inflammation-metaplasia-adenocarcinoma sequence and inflammatory microenvironment in esophageal carcinogenesis using surgical rat models. (2014)
  • Author(s): Miyashita T, Tajima H, Shah FA, Oshima M, Makino I, Nakagawara H, Kitagawa H, Fujimura T, Harmon JW, Ohta T.
  • Journal Title: Ann Surg Oncol Volume: 21 Issue: 6 Pages: 2012-2019
  • DOI: 10.1245/s10434-014-3537-5
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Impact of Inflammation-Metaplasia-Adenocarcinoma Sequence and Inflammatory Microenvironment in Esophageal Carcinogenesis Using Surgical Rat Models (2014)
  • Author(s): Miyashita T, Tajima H, Shah FA, Oshima M, Makino I, Nakagawara H, Kitagawa H, Fujimura T, Harmon JW, Ohta T.
  • Journal Title: Ann Surg Oncol Volume: Epub ahead of print
  • Peer Reviewed
• [Presentation] The inflammatory microenvironment in Duodeno-Esophageal reflux induced esophageal carcinogenesis in a sequential rat model (2013)
  • Author(s): Miyashita T, Munemoto M, Furawn Ashah, John W. Harmon, Fujimura T, Matsui D, Oshima M, Ohta T.
  • Organizer: Digestive Disease Week 2013
  • Place of Presentation: Orange County Convention Center, Orlando (USA)
• [Presentation] 逆流発癌モデルを用いた発癌過程での微小環境の解明 (2013)
  • Author(s): 宮下知治，田島秀浩，中沼伸一，牧野 勇，林 泰寛，梅田尚季，中川原寿敏，高村博之，北川裕久，藤村 隆，太田哲生
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡国際会議場(福岡市）