| Project/Area Number |
25462018
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Mie University |
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Principal Investigator |
Ohi Masaki 三重大学, 医学(系)研究科(研究院), 講師 (40418752)
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| Co-Investigator(Kenkyū-buntansha) |
Kusunoki Masato 三重大学, 医学系研究科, 教授 (50192026)
Mohri Yasuhiko 三重大学, 医学系研究科, 准教授 (70345974)
Toiyama Yuji 三重大学, 医学系研究科, 講師 (00422824)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | lncRNAs / gastric cancer / lymph node metastases / peritoneal dissemination / lncRNA X / 胃癌 / リンパ節転移 / 遠隔転移 / lncRNA |
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| Outline of Final Research Achievements |
We have found out lncRNAs, which had high utility to be involved in metastatic formation so far to elucidate the mechanism of lymph node metastases of gastric cancer. As a result, we were able to identify lncRNA X with the strong association with lymph node metastases and peritoneal dissemination. We showed overexpression of lncRNA X in a gastric cancer tissue as compared with normal mucosa and showed that the expression of lncRNA X is the independent prognostic factor of the survival period. In addition, this lncRNA X was an independent risk factor of the peritoneal dissemination. Furthermore, as a result of having tested participation in growth of lncRNA X in vivo experiment, tumor enlargement was significantly inhibited in the gastric cell lines that were controlled by siRNA to lncRNA X.
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