The development of tumor microenvironment-directed chemotherapy with molecular targeted agent for gastrointestinal cancer
| Project/Area Number |
25462019
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
中村 哲 神戸大学, 医学部附属病院, 講師 (10403247)
掛地 吉弘 神戸大学, 医学研究科, 教授 (80284488)
山下 公大 神戸大学, 医学部附属病院, 特命助教 (80535427)
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 消化器癌 / がん幹細胞 / 浸潤・転移 / 低酸素状態 / 血管新生 |
|---|
| Outline of Final Research Achievements |
We analyzed the change of expression level of HIF-1 and PD-L1 in rectal cancer tissue by chemoradiotherapy. As the expression level of HIF-1 and PD-L1 increased in some cases after chemoradiation, HIF-1 seemed to upregulate the expression of PD-L1. The expression of PD-L1 in tumor cells associated with unfavorable overall survival, and the expression of PD-L1 in lymphocytes around tumor was considered to suppress lymph node metastasis in rectal cancer.
|
Report
(5 results)
Research Products
(8 results)
