| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We analyzed the change of expression level of HIF-1 and PD-L1 in rectal cancer tissue by chemoradiotherapy. As the expression level of HIF-1 and PD-L1 increased in some cases after chemoradiation, HIF-1 seemed to upregulate the expression of PD-L1. The expression of PD-L1 in tumor cells associated with unfavorable overall survival, and the expression of PD-L1 in lymphocytes around tumor was considered to suppress lymph node metastasis in rectal cancer.
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