Therapeutic potential of circulating tumor microenvironment based on metastatic mechanism
| Project/Area Number |
25462020
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Toshiyoshi 岡山大学, 大学院医歯薬学総合研究科, 教授 (00304303)
NOMA Kazuhiro 岡山大学, 大学病院, 助教 (10534761)
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| Research Collaborator |
KASHIMA Hajime 岡山大学, 大学院消化器外科, 大学院生
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | がん微小環境 / がん関連線維芽細胞 / 食道がん / 新規治療薬 / 新規治療法 / 癌関連線維芽細胞 / 食道癌 / 光線免疫療法 / 近赤外線光 |
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| Outline of Final Research Achievements |
The FACS analysis showed the significant increase in the number of cCAF in patients with esophageal cancer specimens compared to a healthy person specimen of the control group. The ELIZA analysis indicated the over-expression of FAP in the supernatant of CAF which is the activated fibroblasts in vitro. FAP expression at tumoral stroma was a significant predictive factor for tumor size, lymph node metastasis and vessel invasion. In survival analysis of DFS (disease free survival) and OS (overall survival), FAP high stroma was associated with shorter period to recurrence and death than those of FAP low stroma.
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Report
(4 results)
Research Products
(4 results)
