Chemoradiotherapy for eshophageal cancer using down-regulation of micro RNA
| Project/Area Number |
25462022
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
Hihara Jun 広島大学, 原爆放射線医科学研究所, 講師 (10322744)
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| Co-Investigator(Kenkyū-buntansha) |
OKADA MORIHITO 広島大学, 原爆放射線医科学研究所, 教授 (70446045)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 食道癌 / 化学放射線療法 / micro RNA / 腫瘍免疫 / 免疫療法 |
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| Outline of Final Research Achievements |
Tumor-specific immunoreaction may play an important role in chemoradiotherapy for esophageal cancer. In esophageal squamous cell carcinoma cell lines, down-regulation of miR-222 and miR-339 might has a potential to up-regulate ICAM-1 expression. These micro RNAs might be candidates for molecular targets to enhance anti-tumor effect in chemoradiotherapy for esophageal cancer with T-cell infiltration.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Completion lobectomy for unanticipated pN1 disease on postoperative pathology after segmentectomy for cT1N0 lung cancer: Prevention of pleural adhesion by using fibrin glue.2015
Author(s)
Miyata, Y., Mimura, T., Tsutani, Y., Ito, M., Misumi, K., Tsubokawa, N., Kai, Y., Kagimoto, A., Hihara, J., Okada, M.
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Journal Title
J Cardiothorac Surg
Volume: 10
Issue: S1
DOI
Related Report
Peer Reviewed
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[Journal Article] Involvement of homologous recombination in the synergism between cisplatin and poly(ADP-ribose) polymerase inhibition2013
Author(s)
Sakogawa K, Aoki Y, Misumi K, Hamai Y, Emi M, Hihara J, Shi L, Kono K, Horikoshi Y, Sun J, Ikura T, Okada M, Tashiro S
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Journal Title
Cancer Sci. 2013 Sep 5
Volume: 104
Issue: 12
Pages: 1593-1609
DOI
Related Report
Peer Reviewed
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[Journal Article] Involvement of ribonucleotide reductase-M1 in 5-fluorouracil induced DNA damage in esophageal cancer cell lines.2013
Author(s)
Aoki Y, Sakogawa K, Hihara J, Emi M, Hamai Y, Kono K, Shi L, Sun J, Kitao H, Ikura T, Niida H, Nakanishi M, Okada M, Tashiro S.
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Journal Title
Int J Oncol.
Volume: 42(6)
Issue: 6
Pages: 1951-60
DOI
Related Report
Peer Reviewed
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