Chemoradiotherapy for eshophageal cancer using down-regulation of micro RNA

• Project/Area Number: 25462022
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Hiroshima University
• Principal Investigator: Hihara Jun 広島大学, 原爆放射線医科学研究所, 講師 (10322744)
• Co-Investigator(Kenkyū-buntansha): OKADA MORIHITO 広島大学, 原爆放射線医科学研究所, 教授 (70446045)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 食道癌 / 化学放射線療法 / micro RNA / 腫瘍免疫 / 免疫療法

Outline of Final Research Achievements

Tumor-specific immunoreaction may play an important role in chemoradiotherapy for esophageal cancer. In esophageal squamous cell carcinoma cell lines, down-regulation of miR-222 and miR-339 might has a potential to up-regulate ICAM-1 expression. These micro RNAs might be candidates for molecular targets to enhance anti-tumor effect in chemoradiotherapy for esophageal cancer with T-cell infiltration.

Research Products

• [Journal Article] Role of definitive chemoradiotherapy using docetaxel and 5-fluorouracil in patients with unresectable locally advanced esophageal squamous cell carcinoma: a phase II study. (2016)
  • Author(s): Hihara J, Hamai Y, Emi M, Murakami Y, Kenjo M, Nagata Y, Okada M.
  • Journal Title: Dis Esophagus Volume: in press Issue: 8 Pages: 1115-20
  • DOI: 10.1111/dote.12433
  • Peer Reviewed
• [Journal Article] Completion lobectomy for unanticipated pN1 disease on postoperative pathology after segmentectomy for cT1N0 lung cancer: Prevention of pleural adhesion by using fibrin glue. (2015)
  • Author(s): Miyata, Y., Mimura, T., Tsutani, Y., Ito, M., Misumi, K., Tsubokawa, N., Kai, Y., Kagimoto, A., Hihara, J., Okada, M.
  • Journal Title: J Cardiothorac Surg Volume: 10 Issue: S1
  • DOI: 10.1186/1749-8090-10-s1-a245
  • Peer Reviewed
• [Journal Article] Emergency escape surgery for a gastro-bronchial fistula with respiratory failure that developed after esophagectomy (2015)
  • Author(s): Ibuki Y, Hamai Y, Hihara J, Taomoto J, Kishimoto I, Miyata Y, Okada M
  • Journal Title: Surg Today Volume: 45 Issue: 3 Pages: 369-373
  • DOI: 10.1007/s00595-013-0821-0
  • Peer Reviewed / Open Access
• [Journal Article] Results of Neoadjuvant Chemoradiotherapy With Docetaxel and 5-Fluorouracil Followed by Esophagectomy to Treat Locally Advanced Esophageal Cancer (2015)
  • Author(s): Hamai Y, Hihara J, Emi M, Murakami Y, Kenjo M, Nagata Y, Okada M
  • Journal Title: Ann Thorac Surg Volume: in press Issue: 6 Pages: 1887-1893
  • DOI: 10.1016/j.athoracsur.2015.02.042
  • Peer Reviewed / Open Access
• [Journal Article] Effects of neoadjuvant chemoradiotherapy on postoperative morbidity and mortality associated with esophageal cancer (2014)
  • Author(s): Hamai Y, Hihara J, Taomoto J, Yamakita I, Ibuki Y, Okada M
  • Journal Title: Dis Esophagus Volume: in press Issue: 4 Pages: 358-364
  • DOI: 10.1111/dote.12207
  • Peer Reviewed / Open Access
• [Journal Article] Hemoglobin level influences tumor response and survival after neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma (2014)
  • Author(s): Hamai Y, Hihara J, Taomoto J, Yamakita I, Ibuki Y, Okada M
  • Journal Title: World J Surg Volume: 38 Issue: 8 Pages: 2046-2051
  • DOI: 10.1007/s00268-014-2486-2
  • Peer Reviewed / Open Access
• [Journal Article] Esophageal bypass operation prior to definitive chemoradiotherapy in advanced esophageal cancer with tracheobronchial invasion (2014)
  • Author(s): Hihara J, Hamai Y, Emi M, Aoki Y, Taomoto J, Miyata Y, Okada M
  • Journal Title: Ann Thorac Surg. Volume: 97 Issue: 1 Pages: 290-5
  • DOI: 10.1016/j.athoracsur.2013.08.060
  • Peer Reviewed
• [Journal Article] Lung Abscess Presenting as Tension Pyopneumothorax in a Gastrointestinal Cancer Patient (2013)
  • Author(s): Okita R, Miyata Y, Hamai Y, Hihara J, Okada M
  • Journal Title: Ann Thorac Cardiovasc Surg Volume: 印刷中
  • NAID: 130003387996
  • Peer Reviewed
• [Journal Article] Involvement of homologous recombination in the synergism between cisplatin and poly(ADP-ribose) polymerase inhibition (2013)
  • Author(s): Sakogawa K, Aoki Y, Misumi K, Hamai Y, Emi M, Hihara J, Shi L, Kono K, Horikoshi Y, Sun J, Ikura T, Okada M, Tashiro S
  • Journal Title: Cancer Sci. 2013 Sep 5 Volume: 104 Issue: 12 Pages: 1593-1609
  • DOI: 10.1111/cas.12281
  • Peer Reviewed
• [Journal Article] Treatment outcomes and prognostic factors for thoracic esophageal cancer with clinical evidence of adjacent organ invasion (2013)
  • Author(s): Hamai Y, Hihara J, Emi M, Taomoto J, Aoki Y, Kishimoto I, Ibuki Y, Okada M
  • Journal Title: Anticancer Res Volume: 33 Pages: 3495-3502
  • Peer Reviewed
• [Journal Article] Involvement of ribonucleotide reductase-M1 in 5-fluorouracil induced DNA damage in esophageal cancer cell lines. (2013)
  • Author(s): Aoki Y, Sakogawa K, Hihara J, Emi M, Hamai Y, Kono K, Shi L, Sun J, Kitao H, Ikura T, Niida H, Nakanishi M, Okada M, Tashiro S.
  • Journal Title: Int J Oncol. Volume: 42(6) Issue: 6 Pages: 1951-60
  • DOI: 10.3892/ijo.2013.1899
  • Peer Reviewed
• [Presentation] 切除可能局所進行食道扁平上皮癌に対する術前化学放射線療法の意義 (2015)
  • Author(s): 檜原淳, 浜井洋一, 山北伊知子, 古川高意, 黒川知彰, 岡田守人
  • Organizer: 第68回日本胸部外科学会定期学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2015-10-18
• [Presentation] Stage II/III食道癌に対する術前化学放射線療法の治療成績 (2015)
  • Author(s): 檜原淳, 浜井洋一, 山北伊知子, 古川高意, 岡田守人
  • Organizer: 第70回日本消化器外科学会総会
  • Place of Presentation: 浜松
  • Year and Date: 2015-07-15
• [Presentation] Near T4食道扇平上皮癌に対する術前化学放射線療法の治療成績 (2015)
  • Author(s): 檜原淳, 浜井洋一, 山北伊知子, 古川高意, 岡田守人
  • Organizer: 第115回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-04-16
• [Presentation] 気管・気管支に浸潤した切除不能胸部食道癌に対する治療戦略 (2014)
  • Author(s): 檎原淳，浜井洋一，山北伊知子，伊富貴雄太，垰本純哉，岡田守人
  • Organizer: 第68回日本食道学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-07-04
• [Presentation] cT3/T4 境界病変に対する術前化学放射線療法の有用性 (2014)
  • Author(s): 山北伊知子，檜原淳，伊富貴雄太，浜井洋一，垰本純哉，岡田守人
  • Organizer: 第57回関西胸部外科学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-06-19 – 2014-06-20
• [Presentation] 局所進行食道癌に対するDocetaxel+ 5-FU併用根治的化学放射線療法の臨床第II相試験 (2014)
  • Author(s): 山北伊知子，檜原淳，青木義朗，垰本純哉，恵美 学，浜井洋一，岡田守人
  • Organizer: 第114回日本外科学会定期学術集会
  • Place of Presentation: 京都
  • Year and Date: 2014-04-03 – 2014-04-05
• [Presentation] 進行食道癌に対する術前化学放射線療法の効果予測因子の検討 (2014)
  • Author(s): 浜井洋一，檜原淳，垰本純哉，山北伊知子，伊富貴雄太，岡田守人
  • Organizer: 第114回日本外科学会定期学術集会
  • Place of Presentation: 京都
  • Year and Date: 2014-04-03 – 2014-04-05
• [Presentation] 食道癌浸潤による食道気管・気管支瘻に対する食道バイパス手術 (2013)
  • Author(s): 檜原淳，浜井洋一，岸本伊知子，伊富貴雄太，垰本純哉，宮田義浩，岡田守人
  • Organizer: 第66回日本胸部外科学会定期学術集会
  • Place of Presentation: 仙台
• [Presentation] 局所進行食道がんに対する術前化学放射線療法－とくにT3/T4境界病変への有用性について－ (2013)
  • Author(s): 檜原淳，浜井洋一，恵美学，青木義朗，岸本伊知子，垰本純哉，岡田守人
  • Organizer: 第68回日本消化器外科学会総会
  • Place of Presentation: 宮崎
• [Presentation] 進行食道肩平上皮癌に対する術前化学放射線療法の治療成績 (2013)
  • Author(s): 檜原淳，浜井洋一，青木義朗，垰本純哉，岸本伊知子，村上祐司，権丈雅浩，永田靖，岡田守人
  • Organizer: 第67回日本食道学会学術集会
  • Place of Presentation: 大阪