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Function analysis of SPINK1 in normal gastric mucosa epithelium and gastric cancer

Research Project

Project/Area Number 25462029
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionKumamoto University

Principal Investigator

OZAKI Nobuyuki  熊本大学, 医学部附属病院, 非常勤診療医師 (40551255)

Co-Investigator(Kenkyū-buntansha) HASHIMOTO Daisuke  熊本大学, 医学部附属病院, 助教 (80508507)
ISHIMOTO Takatsugu  熊本大学, 国際先端医学研究拠点, 客員准教授 (00594889)
Ohmuraya Masaki  熊本大学, 生命資源開発センター, 准教授 (60398229)
WATANABE Masayuki  公益財団法人がん研究会, がん研有明病院, 食道担当部長 (80254639)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords膵分泌性トリプシンインヒビター / 正常胃粘膜 / 胃癌 / PSTI / SPINK1 / EGFR / 膵癌
Outline of Final Research Achievements

We analyzed an expression system of SPINK1 of normal gastric mucosa epithelium and analyzed it in gastric cancer at the same time. SPINK1 expressed to a gastric mucosa cell and worked in protection of gastric mucosa and vulnerary acceleration of ulcer locus. It was particularly strongly confirmed expression in crypt in a stomach and expressed to the cell which had a property of stem cell. We particularly strongly expressed in well differentiated type in gastric cancer, and did not recognize most expression about undifferentiated carcinoma.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] SPINK1 Status in Colorectal Cancer, Impact on Proliferation, and Role in Colitis-associated Cancer.2015

    • Author(s)
      Ida S, Ozaki N, Araki K, Hirashima K, Zaitsu Y, Taki K, Sakamoto Y, Miyamoto Y, Oki E, Morita M, Watanabe M, Maehara Y, Yamamura KI, Baba H Professor, Ohmuraya M.
    • Journal Title

      Molecular Cancer Research

      Volume: - Issue: 7 Pages: 1130-8

    • DOI

      10.1158/1541-7786.mcr-14-0581

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Repeated recurrence of a gastric gastrointestinal stromal tumor on the chest wall after initial curative resection: Report of a case2015

    • Author(s)
      Iwatsuki M, Takamori H, Eto K, Shimizu K, Ogawa K, Yamamura K, Ozaki N, Tanaka H, Sugiyama S, Ogata K, Doi K, Kamio T, Baba H
    • Journal Title

      Int J Surg Case Rep

      Volume: 6C Pages: 36-9

    • DOI

      10.1016/j.ijscr.2014.11.033

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Simultaneous total laparoscopic curative resection for synchronous gastric, cecal and rectal cancer: Report of a case2015

    • Author(s)
      Iwatsuki M, Tanaka H, Shimizu K, Ogawa K, Yamamura K, Ozaki N, Sugiyama S, Ogata K, Doi K, Baba H, Takamori H
    • Journal Title

      Int J Surg Case Rep

      Volume: 6C Pages: 129-32

    • DOI

      10.1016/j.ijscr.2014.11.065

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Definitive diagnosis of a duplicate gallbladder can only be made intraoperatively: report of a case2014

    • Author(s)
      Ozaki N, Hashimoto D, Ikuta Y, Chikamoto A, Takamori H, Baba H
    • Journal Title

      Clin J Gastroenterol

      Volume: 7(4) Issue: 4 Pages: 338-41

    • DOI

      10.1007/s12328-014-0494-2

    • Related Report
      2014 Research-status Report
    • Peer Reviewed

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Published: 2014-07-25   Modified: 2019-07-29  

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