Function analysis of SPINK1 in normal gastric mucosa epithelium and gastric cancer
Project/Area Number |
25462029
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
|
Research Institution | Kumamoto University |
Principal Investigator |
OZAKI Nobuyuki 熊本大学, 医学部附属病院, 非常勤診療医師 (40551255)
|
Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Daisuke 熊本大学, 医学部附属病院, 助教 (80508507)
ISHIMOTO Takatsugu 熊本大学, 国際先端医学研究拠点, 客員准教授 (00594889)
Ohmuraya Masaki 熊本大学, 生命資源開発センター, 准教授 (60398229)
WATANABE Masayuki 公益財団法人がん研究会, がん研有明病院, 食道担当部長 (80254639)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 膵分泌性トリプシンインヒビター / 正常胃粘膜 / 胃癌 / PSTI / SPINK1 / EGFR / 膵癌 |
Outline of Final Research Achievements |
We analyzed an expression system of SPINK1 of normal gastric mucosa epithelium and analyzed it in gastric cancer at the same time. SPINK1 expressed to a gastric mucosa cell and worked in protection of gastric mucosa and vulnerary acceleration of ulcer locus. It was particularly strongly confirmed expression in crypt in a stomach and expressed to the cell which had a property of stem cell. We particularly strongly expressed in well differentiated type in gastric cancer, and did not recognize most expression about undifferentiated carcinoma.
|
Report
(4 results)
Research Products
(4 results)
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[Journal Article] SPINK1 Status in Colorectal Cancer, Impact on Proliferation, and Role in Colitis-associated Cancer.2015
Author(s)
Ida S, Ozaki N, Araki K, Hirashima K, Zaitsu Y, Taki K, Sakamoto Y, Miyamoto Y, Oki E, Morita M, Watanabe M, Maehara Y, Yamamura KI, Baba H Professor, Ohmuraya M.
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Journal Title
Molecular Cancer Research
Volume: -
Issue: 7
Pages: 1130-8
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Repeated recurrence of a gastric gastrointestinal stromal tumor on the chest wall after initial curative resection: Report of a case2015
Author(s)
Iwatsuki M, Takamori H, Eto K, Shimizu K, Ogawa K, Yamamura K, Ozaki N, Tanaka H, Sugiyama S, Ogata K, Doi K, Kamio T, Baba H
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Journal Title
Int J Surg Case Rep
Volume: 6C
Pages: 36-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Simultaneous total laparoscopic curative resection for synchronous gastric, cecal and rectal cancer: Report of a case2015
Author(s)
Iwatsuki M, Tanaka H, Shimizu K, Ogawa K, Yamamura K, Ozaki N, Sugiyama S, Ogata K, Doi K, Baba H, Takamori H
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Journal Title
Int J Surg Case Rep
Volume: 6C
Pages: 129-32
DOI
Related Report
Peer Reviewed
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