Function analysis of SPINK1 in normal gastric mucosa epithelium and gastric cancer
Project/Area Number |
25462029
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
|
Research Institution | Kumamoto University |
Principal Investigator |
OZAKI Nobuyuki 熊本大学, 医学部附属病院, 非常勤診療医師 (40551255)
|
Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Daisuke 熊本大学, 医学部附属病院, 助教 (80508507)
ISHIMOTO Takatsugu 熊本大学, 国際先端医学研究拠点, 客員准教授 (00594889)
Ohmuraya Masaki 熊本大学, 生命資源開発センター, 准教授 (60398229)
WATANABE Masayuki 公益財団法人がん研究会, がん研有明病院, 食道担当部長 (80254639)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 膵分泌性トリプシンインヒビター / 正常胃粘膜 / 胃癌 / PSTI / SPINK1 / EGFR / 膵癌 |
Outline of Final Research Achievements |
We analyzed an expression system of SPINK1 of normal gastric mucosa epithelium and analyzed it in gastric cancer at the same time. SPINK1 expressed to a gastric mucosa cell and worked in protection of gastric mucosa and vulnerary acceleration of ulcer locus. It was particularly strongly confirmed expression in crypt in a stomach and expressed to the cell which had a property of stem cell. We particularly strongly expressed in well differentiated type in gastric cancer, and did not recognize most expression about undifferentiated carcinoma.
|
Report
(4 results)
Research Products
(4 results)
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[Journal Article] SPINK1 status in colorectal cancer, impact on proliferation, and role in Colitis-Associated Cancer.2015
Author(s)
Ida S, Ozaki N, Araki K, Hirashima K, Zaitsu Y, Taki K, Sakamoto Y, Miyamoto Y, Oki E, Morita M, Watanabe M, Maehara Y, Yamamura KI, Baba H, Ohmuraya M
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Journal Title
Molecular Cancer Research
Volume: 印刷中
Pages: 1130-1138
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Repeated recurrence of a gastric gastrointestinal stromal tumor on the chest wall after initial curative resection: Report of a case2015
Author(s)
Iwatsuki M, Takamori H, Eto K, Shimizu K, Ogawa K, Yamamura K, Ozaki N, Tanaka H, Sugiyama S, Ogata K, Doi K, Kamio T, Baba H
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Journal Title
Int J Surg Case Rep
Volume: 6C
Pages: 36-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Simultaneous total laparoscopic curative resection for synchronous gastric, cecal and rectal cancer: Report of a case2015
Author(s)
Iwatsuki M, Tanaka H, Shimizu K, Ogawa K, Yamamura K, Ozaki N, Sugiyama S, Ogata K, Doi K, Baba H, Takamori H
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Journal Title
Int J Surg Case Rep
Volume: 6C
Pages: 129-32
DOI
Related Report
Peer Reviewed
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