Function analysis of SPINK1 in normal gastric mucosa epithelium and gastric cancer

• Project/Area Number: 25462029
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kumamoto University
• Principal Investigator: OZAKI Nobuyuki 熊本大学, 医学部附属病院, 非常勤診療医師 (40551255)
• Co-Investigator(Kenkyū-buntansha): HASHIMOTO Daisuke 熊本大学, 医学部附属病院, 助教 (80508507) ; ISHIMOTO Takatsugu 熊本大学, 国際先端医学研究拠点, 客員准教授 (00594889) ; Ohmuraya Masaki 熊本大学, 生命資源開発センター, 准教授 (60398229) ; WATANABE Masayuki 公益財団法人がん研究会, がん研有明病院, 食道担当部長 (80254639)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 膵分泌性トリプシンインヒビター / 正常胃粘膜 / 胃癌 / PSTI / SPINK1 / EGFR / 膵癌

Outline of Final Research Achievements

We analyzed an expression system of SPINK1 of normal gastric mucosa epithelium and analyzed it in gastric cancer at the same time. SPINK1 expressed to a gastric mucosa cell and worked in protection of gastric mucosa and vulnerary acceleration of ulcer locus. It was particularly strongly confirmed expression in crypt in a stomach and expressed to the cell which had a property of stem cell. We particularly strongly expressed in well differentiated type in gastric cancer, and did not recognize most expression about undifferentiated carcinoma.

Research Products

• [Journal Article] SPINK1 status in colorectal cancer, impact on proliferation, and role in Colitis-Associated Cancer. (2015)
  • Author(s): Ida S, Ozaki N, Araki K, Hirashima K, Zaitsu Y, Taki K, Sakamoto Y, Miyamoto Y, Oki E, Morita M, Watanabe M, Maehara Y, Yamamura KI, Baba H, Ohmuraya M
  • Journal Title: Molecular Cancer Research Volume: 印刷中 Pages: 1130-1138
  • DOI: 10.1158/1541-7786.mcr-14-0581
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Repeated recurrence of a gastric gastrointestinal stromal tumor on the chest wall after initial curative resection: Report of a case (2015)
  • Author(s): Iwatsuki M, Takamori H, Eto K, Shimizu K, Ogawa K, Yamamura K, Ozaki N, Tanaka H, Sugiyama S, Ogata K, Doi K, Kamio T, Baba H
  • Journal Title: Int J Surg Case Rep Volume: 6C Pages: 36-9
  • DOI: 10.1016/j.ijscr.2014.11.033
  • Peer Reviewed
• [Journal Article] Simultaneous total laparoscopic curative resection for synchronous gastric, cecal and rectal cancer: Report of a case (2015)
  • Author(s): Iwatsuki M, Tanaka H, Shimizu K, Ogawa K, Yamamura K, Ozaki N, Sugiyama S, Ogata K, Doi K, Baba H, Takamori H
  • Journal Title: Int J Surg Case Rep Volume: 6C Pages: 129-32
  • DOI: 10.1016/j.ijscr.2014.11.065
  • Peer Reviewed
• [Journal Article] Definitive diagnosis of a duplicate gallbladder can only be made intraoperatively: report of a case (2014)
  • Author(s): Ozaki N, Hashimoto D, Ikuta Y, Chikamoto A, Takamori H, Baba H
  • Journal Title: liCn J Gastroenterol Volume: 7(4) Pages: 338-41
  • DOI: 10.1007/s12328-014-0494-2
  • Peer Reviewed