| Project/Area Number |
25462030
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INOMATA Masafumi 大分大学, 医学部, 教授 (60315330)
SHIRAISHI Norio 大分大学, 医学部, 教授 (20271132)
ETOH Tsuyoshi 大分大学, 医学部, 講師 (00404369)
IWASHITA Yukio 大分大学, 医学部, 講師 (60534203)
HIRATSUKA Takahiro 大分大学, 医学部, 助教 (20600886)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ETS-GS / ケモカイン / リンパ球 / MCP-1 / Ｉｌ-1β / Il-1β / IL-2 / 活性化Ｔ細胞 |
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| Outline of Final Research Achievements |
ETS-GS inhibited the clinical manifestations, histopathological findings of the colon, and inflammatory cytokine, in animal models of the DSS induced colitis. Furthermore, serum MCP-1 and IL-1 β, chemokines in the DSS induced colitis mouse were decreased by ETS-GS administration.
MCP-1 has monocytic activating action, the free promotion effects of the mediator, T-cell chemotactic active effects. Whereas Il-1β has inflammatory promotion effects such as production of the protein in acute phase, the activation of lymphocytes, fever. Il-1β is promoted that production by MCP-1.
It was suggested that the inhibitory effect of these chemokines was associated with a mechanism of the suppression of DSS induced colitis by ETS-GS.
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