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Analysis of the peritoneal dissemination mechanism and minimal cancer cells in gastrointestinal cancer and establishment of the anticancer agent sensitivity laboratory procedure

Research Project

Project/Area Number 25462032
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionKagoshima University

Principal Investigator

Uenosono Yoshikazu  鹿児島大学, 医歯(薬)学総合研究科, 特任准教授 (60398279)

Co-Investigator(Kenkyū-buntansha) ARIGAMI TAKAAKI  鹿児島大学, 医歯学域医学部・歯学部附属病院, 助教 (40527058)
NATSUGOE SHOJI  鹿児島大学, 医歯学域医学系, 教授 (70237577)
柳田 茂寛  鹿児島大学, 医学部・歯学部附属病院, 特任助教 (20444903)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords循環癌細胞 / 腹膜播種 / 個別化化療 / NOGマウス / NOGマウス
Outline of Final Research Achievements

Peritoneal dissemination is one of the major metastatic patterns in patients with advanced gastric cancer. However, it is difficult to diagnose peritoneal tumor dissemination in the clinical management. The purpose of this study is to establish non -invasive diagnosis of free tumor cells in peritoneal cavity. Gastric cancer cell lines were injected into peritoneal cavity of NOG mouse, and we evaluated peritoneal washes by cytology and RT-PCR. Furthermore, peripheral blood was evaluated for detecting circulating tumor cells (CTC). In 30 advanced gastric cancer patients, we performed similar detection. CTC were found 24 hours after the dosage in mice. On the other hands, all of advanced gastric cancer patients with peritoneal dissemination and/ or cytology positive had CTCs. A non-invasive prediction of peritoneal dissemination may be possible by CTC diagnosis.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2015 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Clinical Significance of Circulating Tumor Cells in Peripheral Blood of Patients with Esophageal Squamous Cell Carcinoma.2015

    • Author(s)
      Matsushita D, Uenosono Y, Arigami T, Yanagita S, Nishizono Y, Hagihara T, Hirata M, Haraguchi N, Arima H, Kijima Y, Kurahara H, Maemura K, Okumura H, Ishigami S, Natsugoe S
    • Journal Title

      Ann Surg Oncol

      Volume: 22 Issue: 11 Pages: 3674-3680

    • DOI

      10.1245/s10434-015-4392-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of circulating tumor cells in peripheral blood from patients with gastric cancer.2013

    • Author(s)
      Uenosono Y, Ueno S, et al.
    • Journal Title

      Cancer.

      Volume: 119 Issue: 22 Pages: 3984-3991

    • DOI

      10.1002/cncr.28309

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of stanniocalcin 2 expression as a predictor of tumor progression in gastric cancer2013

    • Author(s)
      Takaaki Arigami
    • Journal Title

      Oncology Reports

      Volume: 30 Issue: 6 Pages: 2838-2844

    • DOI

      10.3892/or.2013.2775

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 切除不能・再発胃癌患者の血中循環癌細胞におけるHER2発現を指標とした治療の可能性2015

    • Author(s)
      上之園芳一, 有上貴明, 柳田茂寛, 大久保啓史, 貴島孝, 松下大輔, 奥村浩, 石神純也, 帆北修一, 夏越祥次
    • Organizer
      第53回日本癌治療学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Evaluation of HER2 expression on Primary Tumor and Circulating Tumor Cells in Patients with Gastric Cancer2015

    • Author(s)
      Uenosono Y., Arigami T., Yanagita S., Matsushita D., Okubo K., Kijima T., Okumura H., Ishigami S., Hokita S., Natsugoe S
    • Organizer
      11th International Gastric Cancer Congress
    • Place of Presentation
      Sao Paulo Brasil
    • Year and Date
      2015-06-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高度進行胃癌の化学療法における血中循環癌細胞の数とHER2発現の変化2015

    • Author(s)
      上之園芳一, 有上貴明, 柳田茂寛, 大久保啓史, 貴島孝, 松下大輔, 有馬豪男, 奥村浩, 石神純也, 帆北修一, 夏越祥次
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Clinical Significance of Circulating Tumor Cells in Peripheral Blood from Patients with Gastric Cancer

    • Author(s)
      Uenosono Y., Arigami T., Yanagita S., Matsushita D., Hirahara S., Ishigami S., Natsugoe S.
    • Organizer
      9th International Symposium on Minimal Residual Cancer
    • Place of Presentation
      Paris France
    • Related Report
      2013 Research-status Report
  • [Presentation] 胃癌における血中遊離癌細胞の検出とHER2発現に基づく臨床応用への可能性

    • Author(s)
      上之園芳一, 有上貴明, 柳田茂寛, 有馬豪男, 萩原貴彦, 原口尚士, 松下大輔, 平原徹志, 石神純也, 帆北修一, 夏越祥次
    • Organizer
      第51回日本癌治療学会学術集会
    • Place of Presentation
      京都市
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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