Identification of compounds to suppress post-chemotherapeutic cancer relapse using drug-tolerant cancer subpopulations
| Project/Area Number |
25462034
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Kume Kohei 岩手医科大学, 医歯薬総合研究所・神経科学研究部門, 助教 (10609663)
前沢 千早 岩手医科大学, 医学部, 教授 (10326647)
若林 剛 岩手医科大学, 医学部, 教授 (50175064)
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| Co-Investigator(Renkei-kenkyūsha) |
Iwaya Takeshi 岩手医科大学, 医学部外科, 講師 (70405801)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 化学療法 / 薬剤耐性 / RNAポリメラーゼ |
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| Outline of Final Research Achievements |
Post-chemotherapeutic cancer relapse has been considered a result of population selection of drug-tolerant colonies (DTCs).The originally developed CoLA technology revealed that DTCs are of two distinct subpopulations expressing either stem cell- or epithelia-associated proteins. The TAF15 gene was identified as one of the uniquely expressed genes in DTCs. Subsequent TAF15 gene knockdown demonstrated a similar morphological change that was seen when RNA polymerase inhibitors were administered. An RNA polymerase inhibitor, alpha-amanitin (alpha-AMA) was identified for suppression of DTCs in vitro. Concurrent administration of alpha-AMA/CDDP suppressed peritoneal dissemination and prolonged survival in a mouse model.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Aipha-Amanitin restrains cancer relapse from drug-tolerant cell subpopulations via TAF-152016
Author(s)
Kume K, Ikeda M, Miura S, Ito K, Sato KA, Ohmori Y, Endo F, Katagiri H, Ishida K, Ito C, Iwaya T, Nishizuka SS
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Journal Title
Sci Rep.
Volume: 6
Pages: 25895-25895
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Intracorporeal reconstruction after laparoscopic pylorus-preserving gastrectomy for middle-third early gastric cancer: a hybrid technique using linear stapler and manual suturing.2016
Author(s)
Koeda K, Chiba T, Noda H, Nishinari Y, Segawa T, Akiyama Y, Iwaya T, Nishizuka S, Nitta H, Otsuka K, Sasaki A.
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Journal Title
Langenbecks Arch Surg
Volume: 401
Issue: 3
Pages: 397-402
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Individualized Mutation Detection in Circulating Tumor DNA for Monitoring Colorectal Tumor Burden Using a Cancer-Associated Gene Sequencing Panel.2016
Author(s)
Sato KA, Hachiya T, Iwaya T, Kume K, Matsuo T, Kawasaki K, Abiko Y, Akasaka R, Matsumoto T, Otsuka K, Nishizuka SS
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Journal Title
PLoS One
Volume: 11
Issue: 1
Pages: e0146275-e0146275
DOI
Related Report
Peer Reviewed / Open Access
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