Development of peritoneal recurrence prediction and therapeutic effect diagnosis in gastric cancer patients
Project/Area Number |
25462038
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Teikyo University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
IINUMA HISAE 帝京大学, 医学部, 講師 (30147102)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 胃癌 / 腹膜播種 / バイオマーカー / 再発予測 / 予後予測 / 治療効果予測 / 癌幹細胞 |
Outline of Final Research Achievements |
Early diagnosis of peritoneal dissemination in gastric cancer patients is important because of the high recurrence rate of this disease. In this study, we examined the usefulness of a peritoneal recurrence genetic diagnosis panel (gene panel) consisting of cancer stem cell and cancer specific markers for gastric cancer (GC). The study was examined the peritoneal lavage fluid of 470 GC patients. The Peritoneal recurrence free survival of the gene panel positive group was significantly worse than that of the gene panel negative group. Genetic markers were independent prognostic factors for peritoneal recurrence. In patients administered with chemotherapeutic drugs (Paclitaxel), the result of the gene panel showed a significant association with peritoneal dissemination. Our results indicate that the newly developed gene panel is a useful tool in the early diagnosis of GC and effective monitoring of the therapeutic effects of chemotherapy in GC patients.
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Report
(3 results)
Research Products
(111 results)
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[Journal Article] Double-blind, placebo-controlled, randomized phase II study of TJ-14 (hangeshashinto) for gastric cancer chemotherapy-induced oral mucositis.2014
Author(s)
Aoyama T, Nishikawa K, Takiguchi N, Tanabe K, Imano M, Fukushima R, Sakamoto J, Oba MS, Morita S, Kono T, Tsuburaya A:
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Journal Title
Cancer chemotherapy and pharmacology
Volume: 73(5)
Issue: 5
Pages: 1047-1054
DOI
Related Report
Peer Reviewed
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[Journal Article] Induction of a pathological complete response by four courses of neoadjuvant chemotherapy for gastric cancer: early results of the randomized phase II COMPASS trial2014
Author(s)
Yoshikawa T, Tanabe K, Nishikawa K, Ito Y, Matsui T, Kimura Y, Hirabayashi N, Mikata S, Iwahashi M, Fukushima R, Takiguchi N, Miyashiro I, Morita S, Miyashita Y, Tsuburaya A, Sakamoto J.
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Journal Title
Annals of Surgical Oncology
Volume: 21
Issue: 1
Pages: 213-219
DOI
Related Report
Peer Reviewed
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[Journal Article] Phase II trial of paclitaxel and cisplatin as neoadjuvant chemotherapy for locally advanced gastric cancer.2013
Author(s)
Tsuburaya A, Nagata N, Cho H, Hirabayashi N, Kobayashi M, Kojima H, Munakata Y, Fukushima R, Kameda Y, Shimoda T, Oba K,Sakamoto J.
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Journal Title
Cancer Chemother Pharmacol
Volume: 71(5)
Issue: 5
Pages: 1309-1314
DOI
Related Report
Peer Reviewed
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[Presentation] Molecular and genomic characteristics of circulating tumor cells (CTCs), and usefulness as biomarker for colorectal cancer patients2015
Author(s)
Hisae Iinuma, Junko Tamura, Mitsuo Tsukamoto, Yasuhisa Fukushima, keisuke Nakamura, Ryu Shimada, Takeshi Tsuchiya, Shoichi Fujii, Keijiro Nozawa, Keiji atsuda, Toshifumi Mogami, Yojiro Hashiguchi
Organizer
53th Annual Meeting the Japanese Society of Clinical Oncology
Place of Presentation
国立京都国際会館{京都府・京都市)
Year and Date
2015-10-29
Related Report
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[Presentation] Clinical impact of plasma exosomal microRNA-21 as a biomarker in each stage of colorectal cancer patients.2015
Author(s)
Hisae Iinuma, Junko Tamura, Mitsuo Tsukamoto, Yasuhisa Fukushima, keisuke Nakamura, Ryu Shimada, Takeshi Tsuchiya, Shoichi Fujii, Keijiro Nozawa, Keiji atsuda, Toshifumi Mogami, Yojiro Hashiguchi
Organizer
74th Annual Meeting the Japanese Cancer Association
Place of Presentation
Nagoya Congress Center ,Nagoya
Year and Date
2015-10-08
Related Report
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[Presentation] Clinical impact and molecular characteristics of circulating tumor cells (CTCs) in patients with colorectal cancer.2015
Author(s)
Junko Tamura, Hisae Iinuma, Mitsuo Tsukamoto, Yasuhisa Fukushima, keisuke Nakamura, Ryu Shimada, Takeshi Tsuchiya, Shoichi Fujii, Keijiro Nozawa, Keiji atsuda, Toshifumi Mogami, Yojiro Hashiguchi
Organizer
74th Annual Meeting the Japanese Cancer Association
Place of Presentation
Nagoya Congress Center ,Nagoya
Year and Date
2015-10-08
Related Report
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[Presentation] Double-Blind, placebo-controlled, randomized phase II study of TJ-14 (Hangeshashinto) for gastric cancer chemotherapy-induced oral mucositis2013
Author(s)
Kazuhiro Nishikawa, Toru Aoyama, Nobuhiro Takiguchi, Kazuaki Tanabe, Mtohiro Imano, Ryoji Fukushima, Akira Tsuburaya, Junichi Sakamoto, Satoshi Morita, Toru Kono
Organizer
EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY 2013
Place of Presentation
Amsterdam, Netherlands
Related Report
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[Presentation] A phase III randomized clinical trial of adjuvant paclitaxel followed by oral fluorinated pyrimidines for locally advanced gastric cancer –SAMIT Study2013
Author(s)
K. Yoshida, A. Tsuburaya, M. Kobayashi, S. Yoshino, M. Takahashi, N. Takiguchi, K. Tanabe, N. Takahashi, H. Imamura, N. Tatsumoto, A. Hara, K. Nishikawa, R. Fukushima, A. Kurita, H. Kojima, Y. Miyashita, K. Oba, ME Buyse, S. Morita, J. Sakamoto
Organizer
American Society for Clinical Oncology (ASCO )49th Annual Meeting
Place of Presentation
Chicago, Illinois, USA
Related Report
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[Presentation] Significance of fluorescence in-situ hybridization for HER2 immunohistochemistry 0 or 1+ metastatic gastric cancer patients -Prospective cohort study JFMC44-11012013
Author(s)
Akira Tsuburaya, Keisho Chin, Atsushi Nashimoto, Kazuhiro Nishikawa, Akira Miki, Hiroto Miwa, Tamon Miyanaga, Takuo Hara, Ryoji Fukushima, Makio Gamoh, Norimasa Fukushima, Takeshi Sano, Yasuhiro Kodera, Yoshihiro Kakeji, Satoshi Morita, Junichi Sakamoto, Shigetoyo Saji, Kazuhiro Yoshida
Organizer
10th International Gastric Cancer Congress (IGCC)
Place of Presentation
Verona, Italy
Related Report
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