An Experimental Study of the Safety and Efficacy of Absorbable Barbed Sutures in Laparoscopic Gastrectomy for Cancer

• Project/Area Number: 25462040
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Osaka Medical College
• Principal Investigator: Lee Sang-Woong 大阪医科大学, 医学部, 講師 (40368080)
• Co-Investigator(Kenkyū-buntansha): 内山 和久 大阪医科大学, 医学部, 教授 (80232867)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 胃癌 / 腹腔鏡下手術 / 体腔内消化管再建 / 新規縫合糸 / Barbed suture / ERASプロトコール / 回復能力強化プログラム / 胃切除術 / 術後回復能力強化プログラム / 内視鏡下手術 / 消化管縫合 / 体組成計 / 体腔内再建 / 消化管再建

Outline of Final Research Achievements

Aim: To investigate the use of the novel barbed suture in gastrointestinal enterotomy closure. Methods: The barbed suture was used to close the entry hole for the linear stapler during intracorporeal reconstruction. Results: The enterotomy hole at 256 sites in 242 patients was closed using the barbed suture. There were no anastomosis-related complications. Conclusions: The use of the barbed absorbable suture for gastrointestinal closure is safe in laparoscopic gastrectomy.
Aim: To clarify the efficacy of the ERAS protocol in patients with gastric cancer. Results: We randomized 148 patients undergoing gastrectomy into an ERAS protocol group and a conventional protocol group. The hospital stay was significantly shorter in the ERAS protocol group. The ERAS protocol group had a significantly lower rate of postoperative complications of grade III or higher. Conclusions: The ERAS protocol is safe and efficient, and seems to improve the postoperative course of patients with gastric cancer.

Research Products

• [Journal Article] Protocol for enhanced recovery after surgery improves short-term outcomes for patients with gastric cancer: a randomized clinical trial (2017)
  • Author(s): Ryo Tanaka,Sang-Woong Lee,Masaru Kawai,Keitaro Tashiro,Satoshi Kawashima,Syuji Kagota,Kotaro Honda,Kazuhisa Uchiyama
  • Journal Title: Gastric Cancer Volume: - Issue: 5 Pages: 861-871
  • DOI: 10.1007/s10120-016-0686-1
  • NAID: 40021705819
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Ｌａｐａｒｏｓｃｏｐｉｃ ｇａｓｔｒｏｉｎｔｅｓｔｉｎａｌ ａｎａｓｔｏｍｏｓｅｓ ｕｓｉｎｇ ｋｎｏｔｌｅｓｓ ｂａｒｂｅｄ ａｂｓｏｒｂａｂｌｅ ｓｕｔｕｒｅｓ ａｒｅ ｓａｆｅ ａｎｄ ｒｅｐｒｏｄｕｃｉｂｌｅ： ａ ｓｉｎｇｌｅ－ｃｅｎｔｅｒ ｅｘｐｅｒｉｅｎｃｅ ｗｉｔｈ ２４２ ｐａｔｉｅｎｔｓ (2016)
  • Author(s): Ｓａｎｇ－Ｗｏｏｎｇ Ｌｅｅ
  • Journal Title: Ｊａｐａｎｅｓｅ Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｏｎｃｏｌｏｇｙ Volume: ４６ Pages: 329-335
  • Peer Reviewed / Open Access
• [Presentation] 幽門側胃切除術におけるERASプロトコールの有用性 (2017)
  • Author(s): 田中 亮、李相雄、河合英、田代圭太郎、革島悟史、駕田修史、本田浩太郎、内山和久
  • Organizer: 第８９回 日本胃癌学会総会
  • Place of Presentation: 広島市
  • Year and Date: 2017-03-08
• [Presentation] 胃がん手術におけるERASに基づく周術期管理の安全性・有効性に関するランダム化比較試験 (2017)
  • Author(s): 李 相雄、田中亮、佐浦隆一、革島悟史、河合英、田代圭太郎、内山和久
  • Organizer: 第３２回 日本静脈経腸栄養学会学術集会
  • Place of Presentation: 岡山市
  • Year and Date: 2017-02-23
• [Presentation] Intracorporeal anastomosis after laparoscopic gastric resection (2016)
  • Author(s): Sang-Woong Lee(李 相雄)
  • Organizer: 15th WCES(World Congress of Endoscopic Surgery) ELSA2016(Endoscopic and Laparoscopic Surgeons of Asia
  • Place of Presentation: Suzhou(China)
  • Year and Date: 2016-11-09
  • Int'l Joint Research / Invited
• [Presentation] 胃癌手術におけるＥＲＡＳプロトコールに沿った周術期管理の安全性・有用性に関する無作為比較試験 (2016)
  • Author(s): 田中亮、李相雄
  • Organizer: 第116回 日本外科学会総会
  • Place of Presentation: 大阪市
  • Year and Date: 2016-04-14
• [Presentation] 腹腔鏡下胃切除術におけるV-Locの安全性に関する単施設前向き観察登録研究 (2016)
  • Author(s): 李相雄、河合英
  • Organizer: 第88回 日本胃癌学会総会
  • Place of Presentation: 大分県別府市
  • Year and Date: 2016-03-17
• [Presentation] 腹腔鏡下胃切除術におけるV-Loc180の有効性に関する単施設前向き観察登録研究 (2013)
  • Author(s): 李相雄
  • Organizer: 第26回日本内視鏡外科学会総会
  • Place of Presentation: 福岡