Detection of free intraperitoneal/circulating tumor cells and possible selection of chemosensitive patientsfor neoadjuvant chemotherapy using gene expression analysis for gastric cancer.
| Project/Area Number |
25462043
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
ITO Seiji 愛知県がんセンター(研究所), 腫瘍病理学部, 研究員 (50393129)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | CTC / フィルター型デバイス開発 / 転移 / CTCマウス / 分子標的治療 / Liquid biopsy / 腹腔洗浄液中がん細胞(PTC) |
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| Outline of Final Research Achievements |
This study aimed the development ofhigh sensitive detection method for CTC/micrometastasesand its preclinical and clinical application to evaluate tumor malignancy and chemosensitivity for the neoadjuvant chemotherapy. We newly developed a filtration-based, sensitive CTC isolation device and mouse CTC model. Using this system, we demonstrated M stage-arrested CTC in mouse blood after Paclitaxel treatment, indicatingthe possibility for successful evaluation of chemosensitivity at an early stage after therapy. We also revealed that our CTC isolation device allows more sensitive CTC detection and more rapid genetic analysis of patient’s blood samples than the conventional device. These results suggest that this CTC isolation device would be an useful tool to evaluate tumor malignancy and chemosensitivityas a liquid biopsy.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] A Case of Gastric Cancer with Residual Tumor Only in the Para-Aortic Lymph Nodes after Systemic Chemotherapy followed by Conversion Surgery.2015
Author(s)
Tsutsuyama M, Ito S, Ito Y, Misawa K, Kawakami J, Natsume S, Uemura N, Kinoshita T, Kimura K, Senda Y, Abe T, Komori K, Yatabe Y, Niwa Y, Shimizu Y, Kinoshita T.
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Journal Title
Case Reports in Oncology
Volume: 8
Issue: 2
Pages: 312-322
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Survival analysis of adjuvant chemotherapy with S-1 plus cisplatin for stage III gastric cancer.2014
Author(s)
Takahari D, Hamaguchi T, Yoshimura K, Katai H, Ito S, Fuse N, Konishi M, Yasui H, Terashima M, Goto M, Tanigawa N, Shirao K, Sano T, Sasako M.
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Journal Title
Gastric Cancer
Volume: 17
Issue: 2
Pages: 383-386
DOI
Related Report
Peer Reviewed
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