Expression of stem cell marker CD133 in ulcerative colitis-associated colorectal cancer and dysplasia

• Project/Area Number: 25462046
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: The University of Tokyo
• Principal Investigator: KAZAMA SHINSUKE 東京大学, 医学部附属病院, 登録研究員 (60401098)
• Co-Investigator(Kenkyū-buntansha): YAMAGUCHI Hironori 東京大学, 医学部附属病院, 講師 (20376445) ; SUNAMI Eiji 東京大学, 医学部附属病院, 登録研究員 (70345205) ; WATANABE Toshiaki 東京大学, 医学部附属病院, 教授 (80210920)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 癌幹細胞 / CD133 / 大腸癌 / 大腸ポリープ / 潰瘍性大腸炎 / 炎症性発癌 / 異型度 / 腫瘍径

Outline of Final Research Achievements

Immunohistochemical expression of stem cell marker CD133
1) CD133 might play an important role in both tumor development and progression in colorectal polyps. 2) CD133-positive cancer might be more aggressive than CD133-negative cancer during the process of lymph node metastasis. 3) CD133 expression in liver metastases had significant correlation with CD133 expression in primary lesion. Patients without CD133 expression in liver metastasis had significantly shorter survival, perhaps because mCD133- patients had a significantly higher rate of extrahepatic recurrence. 4) CD133 might play an important role in ulcerative colitis-associated colorectal cancer and dysplasia.

Research Products

• [Journal Article] CD133 Expression at the Metastatic Site Predicts Patients' Outcome in Colorectal Cancer with Synchronous Liver Metastasis. (2016)
  • Author(s): Kishikawa J, Kazama S, Oba K, Hasegawa K, Anzai H, Harada Y, Abe H, Matsusaka K, Hongo K, Oba M, Yasuda K, Otani K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Hata K, Kawai K, Nozawa H, Yamaguchi H, Ishihara S, Sunami E, Ushiku T, Kitayama J, Fukayama M, Kokudo N, Watanabe T.
  • Journal Title: Ann Surg Oncol. Volume: in press
  • Peer Reviewed
• [Journal Article] CD133 Expression in Lymph Node Metastases Is Associated with Tumor Aggressiveness During Lymph Node Metastasis in Colorectal Cancer. (2015)
  • Author(s): Kazama S, Kishikawa J, Yasuda K, Otani K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Nozawa H, Yamaguchi H, Ishihara S, Sunami E, Watanabe T.
  • Journal Title: Anticancer Res. Volume: 35 Pages: 6599-6605
  • Peer Reviewed
• [Journal Article] Efficacy of magnetic resonance imaging in the diagnosis of perianal hidradenitis suppurativa, complicated by anal fistulae: A report of two cases and review of the literature. (2015)
  • Author(s): Takiyama H, Kazama S, Tanoue Y, Yasuda K, Otani K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Hata K, Kawai K, Nozawa H, Miyagawa T, Yamada D, Yamaguchi H, I shihara S, Sunami E, Watanabe T.
  • Journal Title: Int J Surg Case Rep. Volume: 15 Pages: 107-111
  • DOI: 10.1016/j.ijscr.2015.08.028
  • Peer Reviewed
• [Journal Article] Impact of a lymphocyte to monocyte ratio in stage IV colorectal cancer. (2015)
  • Author(s): Ozawa T, Ishihara S, Kawai K, Kazama S, Yamaguchi H, Sunami E, Kitayama J, Watan abe T.
  • Journal Title: J Surg Res. Volume: 199 Issue: 2 Pages: 386-392
  • DOI: 10.1016/j.jss.2015.06.014
  • Peer Reviewed
• [Journal Article] Alpha-fetoprotein-producing early rectal carcinoma: a rare case report and review. (2015)
  • Author(s): Anzai H, Kazama S, Kiyomatsu T, Nishikawa T, Tanaka T, Tanaka J, Hata K, Kawai K , Yamaguchi H, Nozawa H, Kanazawa T, Ushiku T, Ishihara S, Sunami E, Fukayama M, Watanabe T.
  • Journal Title: World J Surg Oncol. Volume: 13 Issue: 1 Pages: 180-180
  • DOI: 10.1186/s12957-015-0590-x
  • Peer Reviewed
• [Presentation] 潰瘍性大腸炎の炎症性発癌経路におけるCD133発現の免疫組織学的検討 (2016)
  • Author(s): 風間伸介、山口博紀、石原総一郎、西村洋治、川島吉之、坂本裕彦、渡邉聡明
  • Organizer: 第71回日本消化器外科学会総会
  • Place of Presentation: あわぎんホール（徳島県、徳島市）
  • Year and Date: 2016-07-14
• [Presentation] Stage III大腸癌におけるCD133免疫組織学的発現と臨床病理学的因子の検討 (2015)
  • Author(s): 第115回日本外科学会定期学術集会
  • Organizer: 風間伸介、岸川純子、西川武司、田中敏明、田中潤一郎、清松知充、畑啓介、川合一茂、野澤宏彰、山口博紀、石原総一郎、須並英二、渡邉聡明
  • Place of Presentation: 名古屋国際会議場（愛知県、名古屋市）
  • Year and Date: 2015-04-18
• [Presentation] 大腸癌肝転移症例におけるCD133発現の免疫組織学的検討 (2015)
  • Author(s): 第115回日本外科学会定期学術集会
  • Organizer: 岸川純子 風間伸介 長谷川潔 本郷久美子 山口博紀 石原聡一郎 須並英二 牛久哲男 北山丈二 深山正久 國土典宏 渡邉聡明
  • Place of Presentation: 名古屋国際会議場（愛知県、名古屋市）
  • Year and Date: 2015-04-18