Expression of stem cell marker CD133 in ulcerative colitis-associated colorectal cancer and dysplasia
| Project/Area Number |
25462046
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KAZAMA SHINSUKE 東京大学, 医学部附属病院, 登録研究員 (60401098)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Hironori 東京大学, 医学部附属病院, 講師 (20376445)
SUNAMI Eiji 東京大学, 医学部附属病院, 登録研究員 (70345205)
WATANABE Toshiaki 東京大学, 医学部附属病院, 教授 (80210920)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 癌幹細胞 / CD133 / 大腸癌 / 大腸ポリープ / 潰瘍性大腸炎 / 炎症性発癌 / 異型度 / 腫瘍径 |
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| Outline of Final Research Achievements |
Immunohistochemical expression of stem cell marker CD133
1) CD133 might play an important role in both tumor development and progression in colorectal polyps. 2) CD133-positive cancer might be more aggressive than CD133-negative cancer during the process of lymph node metastasis. 3) CD133 expression in liver metastases had significant correlation with CD133 expression in primary lesion. Patients without CD133 expression in liver metastasis had significantly shorter survival, perhaps because mCD133- patients had a significantly higher rate of extrahepatic recurrence. 4) CD133 might play an important role in ulcerative colitis-associated colorectal cancer and dysplasia.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] CD133 Expression at the Metastatic Site Predicts Patients' Outcome in Colorectal Cancer with Synchronous Liver Metastasis.2016
Author(s)
Kishikawa J, Kazama S, Oba K, Hasegawa K, Anzai H, Harada Y, Abe H, Matsusaka K, Hongo K, Oba M, Yasuda K, Otani K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Hata K, Kawai K, Nozawa H, Yamaguchi H, Ishihara S, Sunami E, Ushiku T, Kitayama J, Fukayama M, Kokudo N, Watanabe T.
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Journal Title
Ann Surg Oncol.
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] CD133 Expression in Lymph Node Metastases Is Associated with Tumor Aggressiveness During Lymph Node Metastasis in Colorectal Cancer.2015
Author(s)
Kazama S, Kishikawa J, Yasuda K, Otani K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Nozawa H, Yamaguchi H, Ishihara S, Sunami E, Watanabe T.
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Journal Title
Anticancer Res.
Volume: 35
Pages: 6599-6605
Related Report
Peer Reviewed
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[Journal Article] Efficacy of magnetic resonance imaging in the diagnosis of perianal hidradenitis suppurativa, complicated by anal fistulae: A report of two cases and review of the literature.2015
Author(s)
Takiyama H, Kazama S, Tanoue Y, Yasuda K, Otani K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Hata K, Kawai K, Nozawa H, Miyagawa T, Yamada D, Yamaguchi H, I shihara S, Sunami E, Watanabe T.
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Journal Title
Int J Surg Case Rep.
Volume: 15
Pages: 107-111
DOI
Related Report
Peer Reviewed
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[Journal Article] Alpha-fetoprotein-producing early rectal carcinoma: a rare case report and review.2015
Author(s)
Anzai H, Kazama S, Kiyomatsu T, Nishikawa T, Tanaka T, Tanaka J, Hata K, Kawai K , Yamaguchi H, Nozawa H, Kanazawa T, Ushiku T, Ishihara S, Sunami E, Fukayama M, Watanabe T.
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Journal Title
World J Surg Oncol.
Volume: 13
Issue: 1
Pages: 180-180
DOI
Related Report
Peer Reviewed
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